Pilankatta R, Lewis D, Inesi G (2011) Involvement of protein kinase D in expression and trafficking of ATP7B (copper ATPase). J Biol Chem 286, 7389-96 21189263

This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2015, 43:D512-20). To learn more about the scope of PhosphoSitePlus®, click here.

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S478-p - ATP7B (human) ▲

Modsite: APDILAKsPQsTRAV SwissProt Entrez-Gene Orthologous residues ATP7B (human): S478‑p, ATP7B iso2 (human): S478‑p, ATP7B (mouse): T480‑p, ATP7B (rat): S471‑p Characterization Methods used to characterize site in vivo:  [32P] ATP in vitro, mutation of modification site, western blotting Disease tissue studied:  hepatocellular carcinoma Relevant cell lines - cell types - tissues:  COS (fibroblast), Hep-G2/C3A (hepatic) Cellular systems studied:  cell lines Species studied:  green monkey, human Enzymes shown to modify site in vitro:  Type Enzyme KINASE PRKD1 (human) Upstream Regulation Treatments, proteins and their effect on site modification:  Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes CID755673 decrease phorbol_ester increase Downstream Regulation Effect of modification (function):  intracellular localization, protein stabilization Comments:  protein trafficking

S481-p - ATP7B (human) ▲

Modsite: ILAKsPQsTRAVAPQ SwissProt Entrez-Gene Orthologous residues ATP7B (human): S481‑p, ATP7B iso2 (human): S481‑p, ATP7B (mouse): S483‑p, ATP7B (rat): S474‑p Characterization Methods used to characterize site in vivo:  [32P] ATP in vitro, mutation of modification site, western blotting Disease tissue studied:  hepatocellular carcinoma Relevant cell lines - cell types - tissues:  COS (fibroblast), Hep-G2/C3A (hepatic) Cellular systems studied:  cell lines Species studied:  green monkey, human Enzymes shown to modify site in vitro:  Type Enzyme KINASE PRKD1 (human) Upstream Regulation Treatments, proteins and their effect on site modification:  Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes CID755673 decrease phorbol_ester increase Downstream Regulation Effect of modification (function):  intracellular localization, protein stabilization Comments:  protein trafficking

S1121-p - ATP7B (human) ▲

Modsite: AHSERPLsAPASHLN SwissProt Entrez-Gene Orthologous residues ATP7B (human): S1121‑p, ATP7B iso2 (human): S914‑p, ATP7B (mouse): ‑, ATP7B (rat): ‑ Characterization Methods used to characterize site in vivo:  [32P] ATP in vitro, mutation of modification site, western blotting Disease tissue studied:  hepatocellular carcinoma Relevant cell lines - cell types - tissues:  COS (fibroblast), Hep-G2/C3A (hepatic) Cellular systems studied:  cell lines Species studied:  green monkey, human Enzymes shown to modify site in vitro:  Type Enzyme KINASE PRKD1 (human) Upstream Regulation Treatments, proteins and their effect on site modification:  Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes CID755673 decrease phorbol_ester increase Downstream Regulation Effect of modification (function):  intracellular localization, protein stabilization Comments:  protein trafficking

S1453-p - ATP7B (human) ▲

Modsite: DDDGDKWsLLLNGRD SwissProt Entrez-Gene Orthologous residues ATP7B (human): S1453‑p, ATP7B iso2 (human): S1246‑p, ATP7B (mouse): S1450‑p, ATP7B (rat): S1439‑p Characterization Methods used to characterize site in vivo:  [32P] ATP in vitro, mutation of modification site, western blotting Disease tissue studied:  hepatocellular carcinoma Relevant cell lines - cell types - tissues:  COS (fibroblast), Hep-G2/C3A (hepatic) Cellular systems studied:  cell lines Species studied:  green monkey, human Enzymes shown to modify site in vitro:  Type Enzyme KINASE PRKD1 (human) Upstream Regulation Treatments, proteins and their effect on site modification:  Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes CID755673 decrease phorbol_ester increase Downstream Regulation Effect of modification (function):  intracellular localization, protein stabilization Comments:  protein trafficking