Nagel F, et al. (2011) Structural Determinants of Agonist-Selective Signaling at the sst2A Somatostatin Receptor. Mol Endocrinol 25, 859-66 21330405

This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2015, 43:D512-20). To learn more about the scope of PhosphoSitePlus®, click here.

Click on the protein name to open the protein page, and on the RSD number to open the site page.

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S341-p - SSTR2 (human) ▲

Modsite: GTDDGERsDsKQDKS SwissProt Entrez-Gene Orthologous residues SSTR2 (human): S341‑p, SSTR2 (mouse): S341‑p, SSTR2 (rat): S341‑p Characterization Methods used to characterize site in vivo:  phospho-antibody, western blotting Relevant cell lines - cell types - tissues:  293 (epithelial) Cellular systems studied:  cell lines Species studied:  human Upstream Regulation Potential in vivo enzymes for site:  Type Enzyme Evidence Notes KINASE GRK3 (human) siRNA inhibition of enzyme Treatments, proteins and their effect on site modification:  Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes octreotide increase pasireotide increase Downstream Regulation Effect of modification (function):  receptor internalization, altered

S343-p - SSTR2 (human) ▲

Modsite: DDGERsDsKQDKSRL SwissProt Entrez-Gene Orthologous residues SSTR2 (human): S343‑p, SSTR2 (mouse): S343‑p, SSTR2 (rat): S343‑p Characterization Methods used to characterize site in vivo:  phospho-antibody, western blotting Relevant cell lines - cell types - tissues:  293 (epithelial) Cellular systems studied:  cell lines Species studied:  human Upstream Regulation Potential in vivo enzymes for site:  Type Enzyme Evidence Notes KINASE GRK3 (human) siRNA inhibition of enzyme Treatments, proteins and their effect on site modification:  Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes octreotide increase pasireotide increase Downstream Regulation Effect of modification (function):  receptor internalization, altered

S341-p - SSTR2 (rat) ▲

Modsite: GAEDGERsDsKQDKs SwissProt Orthologous residues SSTR2 (human): S341‑p, SSTR2 (mouse): S341‑p, SSTR2 (rat): S341‑p Characterization Methods used to characterize site in vivo:  phospho-antibody, western blotting Relevant cell lines - cell types - tissues:  293 (epithelial) Cellular systems studied:  cell lines Species studied:  human Upstream Regulation Treatments, proteins and their effect on site modification:  Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes SST14 increase octreotide increase pasireotide no change compared to control

S343-p - SSTR2 (rat) ▲

Modsite: EDGERsDsKQDKsRL SwissProt Orthologous residues SSTR2 (human): S343‑p, SSTR2 (mouse): S343‑p, SSTR2 (rat): S343‑p Characterization Methods used to characterize site in vivo:  phospho-antibody, western blotting Relevant cell lines - cell types - tissues:  293 (epithelial) Cellular systems studied:  cell lines Species studied:  human Upstream Regulation Treatments, proteins and their effect on site modification:  Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes SST14 increase octreotide increase pasireotide no change compared to control

T353-p - SSTR2 (rat) ▲

Modsite: DKsRLNEttEtQRtL SwissProt Orthologous residues SSTR2 (human): T353‑p, SSTR2 (mouse): T353‑p, SSTR2 (rat): T353‑p Characterization Methods used to characterize site in vivo:  phospho-antibody, western blotting Relevant cell lines - cell types - tissues:  293 (epithelial) Cellular systems studied:  cell lines Species studied:  human Upstream Regulation Treatments, proteins and their effect on site modification:  Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes SST14 increase octreotide increase pasireotide no change compared to control

T354-p - SSTR2 (rat) ▲

Modsite: KsRLNEttEtQRtLL SwissProt Orthologous residues SSTR2 (human): T354‑p, SSTR2 (mouse): T354‑p, SSTR2 (rat): T354‑p Characterization Methods used to characterize site in vivo:  phospho-antibody, western blotting Relevant cell lines - cell types - tissues:  293 (epithelial) Cellular systems studied:  cell lines Species studied:  human Upstream Regulation Treatments, proteins and their effect on site modification:  Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes SST14 increase octreotide increase pasireotide no change compared to control

T356-p - SSTR2 (rat) ▲

Modsite: RLNEttEtQRtLLNG SwissProt Orthologous residues SSTR2 (human): T356‑p, SSTR2 (mouse): T356‑p, SSTR2 (rat): T356‑p Characterization Methods used to characterize site in vivo:  phospho-antibody, western blotting Relevant cell lines - cell types - tissues:  293 (epithelial) Cellular systems studied:  cell lines Species studied:  human Upstream Regulation Treatments, proteins and their effect on site modification:  Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes SST14 increase octreotide increase pasireotide no change compared to control

T359-p - SSTR2 (rat) ▲

Modsite: EttEtQRtLLNGDLQ SwissProt Orthologous residues SSTR2 (human): T359‑p, SSTR2 (mouse): T359‑p, SSTR2 (rat): T359‑p Characterization Methods used to characterize site in vivo:  phospho-antibody, western blotting Relevant cell lines - cell types - tissues:  293 (epithelial) Cellular systems studied:  cell lines Species studied:  human Upstream Regulation Treatments, proteins and their effect on site modification:  Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes SST14 increase octreotide increase pasireotide no change compared to control