Curated Information
Javascript is not enabled on this browser. This site will not work properly without Javascript.
PhosphoSitePlus Homepage PhosphoSitePlus® v6.5.9.3
Powered by Cell Signaling Technology
Home > Curated Information Page > PubMed Id: 21330405
Nagel F, et al. (2011) Structural Determinants of Agonist-Selective Signaling at the sst2A Somatostatin Receptor. Mol Endocrinol 25, 859-66 21330405
This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2015, 43:D512-20). To learn more about the scope of PhosphoSitePlus®, click here.
Click on the protein name to open the protein page, and on the RSD number to open the site page.
Download

S341-p - SSTR2 (human)
Modsite: GTDDGERsDsKQDKS SwissProt Entrez-Gene
Orthologous residues
SSTR2 (human): S341‑p, SSTR2 (mouse): S341‑p, SSTR2 (rat): S341‑p
Characterization
Methods used to characterize site in vivo phospho-antibody, western blotting
Relevant cell lines - cell types - tissues:  293 (epithelial)
Cellular systems studied:  cell lines
Species studied:  human
Upstream Regulation
Potential in vivo enzymes for site: 
Type Enzyme Evidence Notes
KINASE GRK3 (human) siRNA inhibition of enzyme
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
octreotide increase
pasireotide increase
Downstream Regulation
Effect of modification (function):  receptor internalization, altered

S343-p - SSTR2 (human)
Modsite: DDGERsDsKQDKSRL SwissProt Entrez-Gene
Orthologous residues
SSTR2 (human): S343‑p, SSTR2 (mouse): S343‑p, SSTR2 (rat): S343‑p
Characterization
Methods used to characterize site in vivo phospho-antibody, western blotting
Relevant cell lines - cell types - tissues:  293 (epithelial)
Cellular systems studied:  cell lines
Species studied:  human
Upstream Regulation
Potential in vivo enzymes for site: 
Type Enzyme Evidence Notes
KINASE GRK3 (human) siRNA inhibition of enzyme
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
octreotide increase
pasireotide increase
Downstream Regulation
Effect of modification (function):  receptor internalization, altered

S341-p - SSTR2 (rat)
Modsite: GAEDGERsDsKQDKs SwissProt
Orthologous residues
SSTR2 (human): S341‑p, SSTR2 (mouse): S341‑p, SSTR2 (rat): S341‑p
Characterization
Methods used to characterize site in vivo phospho-antibody, western blotting
Relevant cell lines - cell types - tissues:  293 (epithelial)
Cellular systems studied:  cell lines
Species studied:  human
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
SST14 increase
octreotide increase
pasireotide no change compared to control

S343-p - SSTR2 (rat)
Modsite: EDGERsDsKQDKsRL SwissProt
Orthologous residues
SSTR2 (human): S343‑p, SSTR2 (mouse): S343‑p, SSTR2 (rat): S343‑p
Characterization
Methods used to characterize site in vivo phospho-antibody, western blotting
Relevant cell lines - cell types - tissues:  293 (epithelial)
Cellular systems studied:  cell lines
Species studied:  human
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
SST14 increase
octreotide increase
pasireotide no change compared to control

T353-p - SSTR2 (rat)
Modsite: DKsRLNEttEtQRtL SwissProt
Orthologous residues
SSTR2 (human): T353‑p, SSTR2 (mouse): T353‑p, SSTR2 (rat): T353‑p
Characterization
Methods used to characterize site in vivo phospho-antibody, western blotting
Relevant cell lines - cell types - tissues:  293 (epithelial)
Cellular systems studied:  cell lines
Species studied:  human
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
SST14 increase
octreotide increase
pasireotide no change compared to control

T354-p - SSTR2 (rat)
Modsite: KsRLNEttEtQRtLL SwissProt
Orthologous residues
SSTR2 (human): T354‑p, SSTR2 (mouse): T354‑p, SSTR2 (rat): T354‑p
Characterization
Methods used to characterize site in vivo phospho-antibody, western blotting
Relevant cell lines - cell types - tissues:  293 (epithelial)
Cellular systems studied:  cell lines
Species studied:  human
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
SST14 increase
octreotide increase
pasireotide no change compared to control

T356-p - SSTR2 (rat)
Modsite: RLNEttEtQRtLLNG SwissProt
Orthologous residues
SSTR2 (human): T356‑p, SSTR2 (mouse): T356‑p, SSTR2 (rat): T356‑p
Characterization
Methods used to characterize site in vivo phospho-antibody, western blotting
Relevant cell lines - cell types - tissues:  293 (epithelial)
Cellular systems studied:  cell lines
Species studied:  human
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
SST14 increase
octreotide increase
pasireotide no change compared to control

T359-p - SSTR2 (rat)
Modsite: EttEtQRtLLNGDLQ SwissProt
Orthologous residues
SSTR2 (human): T359‑p, SSTR2 (mouse): T359‑p, SSTR2 (rat): T359‑p
Characterization
Methods used to characterize site in vivo phospho-antibody, western blotting
Relevant cell lines - cell types - tissues:  293 (epithelial)
Cellular systems studied:  cell lines
Species studied:  human
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
SST14 increase
octreotide increase
pasireotide no change compared to control