Curated Information
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Home > Curated Information Page > PubMed Id: 21347269
Hammelmann V, et al. (2011) The cGMP-Dependent Protein Kinase II Is an Inhibitory Modulator of the Hyperpolarization-Activated HCN2 Channel. PLoS One 6, e17078 21347269
This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2015, 43:D512-20). To learn more about the scope of PhosphoSitePlus®, click here.
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S641-p - HCN2 (mouse)
Modsite: DRIGKKNsILLHKVQ SwissProt Entrez-Gene
Orthologous residues
HCN2 (human): S668‑p, HCN2 (mouse): S641‑p, HCN2 (rat): S641‑p
Methods used to characterize site in vivo immunoprecipitation, mutation of modification site, western blotting
Relevant cell lines - cell types - tissues:  293 (epithelial), neuron-'brain, hippocampus'
Cellular systems studied:  cell lines, tissue
Species studied:  human
Upstream Regulation
Potential in vivo enzymes for site: 
Type Enzyme Evidence Notes
KINASE PKG2 (human) transfection of wild-type enzyme, co-immunoprecipitation
Downstream Regulation
Effect of modification (function):  activity, inhibited