Chachami G, et al. (2019) Hypoxia-induced Changes in SUMO Conjugation Affect Transcriptional Regulation Under Low Oxygen. Mol Cell Proteomics 18, 1197-1209 30926672

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K10-sm - AP-2 alpha (human) ▲

Modsite: WKLTDNIkYEDCEDR SwissProt Entrez-Gene Orthologous residues AP‑2 alpha (human): K10‑sm, AP‑2 alpha iso2 (human): ‑, AP‑2 alpha (mouse): K10‑sm, AP‑2 alpha (rat): ‑ Characterization Methods used to characterize site in vivo:  immunoprecipitation, mutation of modification site, western blotting Relevant cell lines - cell types - tissues:  HeLa (cervical) Cellular systems studied:  cell lines Species studied:  HPIV3 Upstream Regulation Potential in vivo enzymes for site:  Type Enzyme Evidence Notes ACETYLTRANSFERASE p300 (human) pharmacological inhibitor of upstream enzyme, co-immunoprecipitation, siRNA inhibition of enzyme Treatments, proteins and their effect on site modification:  Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes hypoxia decrease Downstream Regulation Effect of modification (function):  activity, induced Effect of modification (process):  transcription, induced Comments:  enhances transcription of HIF1A