Curated Information
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Home > Curated Information Page > PubMed Id: 21224484
Oh KJ, et al. (2011) Atypical antipsychotic drugs perturb AMPK-dependent regulation of hepatic lipid metabolism. Am J Physiol Endocrinol Metab 300, E624-32 21224484
This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2015, 43:D512-20). To learn more about the scope of PhosphoSitePlus®, click here.
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S6-p - PPAR-alpha (human)
Modsite: __MVDTEsPLCPLsP SwissProt Entrez-Gene
Orthologous residues
PPAR‑alpha (human): S6‑p, PPAR‑alpha (mouse): S6‑p, PPAR‑alpha (rat): S6‑p

S12-p - PPAR-alpha (human)
Modsite: EsPLCPLsPLEAGDL SwissProt Entrez-Gene
Orthologous residues
PPAR‑alpha (human): S12‑p, PPAR‑alpha (mouse): S12‑p, PPAR‑alpha (rat): S12‑p

S21-p - PPAR-alpha (human)
Modsite: LEAGDLEsPLSEEFL SwissProt Entrez-Gene
Orthologous residues
PPAR‑alpha (human): S21‑p, PPAR‑alpha (mouse): S21‑p, PPAR‑alpha (rat): S21‑p

S79-p - ACC1 (rat)
Modsite: FHMRSsMsGLHLVKQ SwissProt Entrez-Gene
Orthologous residues
ACC1 (human): S80‑p, ACC1 iso2 (human): S22‑p, ACC1 iso4 (human): S117‑p, ACC1 (mouse): S79‑p, ACC1 iso2 (mouse): S117‑p, ACC1 (rat): S79‑p, ACC1 iso2 (rat): S79‑p
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
olanzapine, clozapine decrease

T172-p - AMPKA2 (rat)
Modsite: SDGEFLRtsCGSPNY SwissProt Entrez-Gene
Orthologous residues
AMPKA2 (human): T172‑p, AMPKA2 (mouse): T172‑p, AMPKA2 (rat): T172‑p, AMPKA2 (pig): T172‑p
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
olanzapine, clozapine decrease