Dimke H, et al. (2011) γ-Adducin stimulates the thiazide-sensitive NaCl cotransporter. J Am Soc Nephrol 22, 508-17 21164023

This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2015, 43:D512-20). To learn more about the scope of PhosphoSitePlus®, click here.

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T55-p - NCCT (human) ▲

Modsite: SStFCMRtFGYNtID SwissProt Entrez-Gene Orthologous residues NCCT (human): T55‑p, NCCT iso2 (human): T55‑p, NCCT iso3 (human): T55‑p, NCCT (mouse): T53‑p, NCCT (rat): T53‑p Characterization Methods used to characterize site in vivo:  mutation of modification site Relevant cell lines - cell types - tissues:  oocyte Cellular systems studied:  primary cultured cells Species studied:  frog Downstream Regulation Effect of modification (function):  molecular association, regulation Modification regulates interactions with:  Interacting molecule Interacting domains Effect Consequences (function) Consequences (process) Detection assays ADD3 (human) Disrupts pull-down assay Comments:  ADD3 stimulates SLC12A3 activity

T60-p - NCCT (human) ▲

Modsite: MRtFGYNtIDVVPtY SwissProt Entrez-Gene Orthologous residues NCCT (human): T60‑p, NCCT iso2 (human): T60‑p, NCCT iso3 (human): T60‑p, NCCT (mouse): T58‑p, NCCT (rat): T58‑p Characterization Methods used to characterize site in vivo:  mutation of modification site Relevant cell lines - cell types - tissues:  oocyte Cellular systems studied:  primary cultured cells Species studied:  frog Downstream Regulation Effect of modification (function):  molecular association, regulation Modification regulates interactions with:  Interacting molecule Interacting domains Effect Consequences (function) Consequences (process) Detection assays ADD3 (human) Disrupts pull-down assay Comments:  ADD3 stimulates SLC12A3 activity

S73-p - NCCT (human) ▲

Modsite: tYEHyANstQPGEPR SwissProt Entrez-Gene Orthologous residues NCCT (human): S73‑p, NCCT iso2 (human): S73‑p, NCCT iso3 (human): S73‑p, NCCT (mouse): S71‑p, NCCT (rat): S71‑p Characterization Methods used to characterize site in vivo:  mutation of modification site Relevant cell lines - cell types - tissues:  oocyte Cellular systems studied:  primary cultured cells Species studied:  frog Downstream Regulation Effect of modification (function):  molecular association, regulation Modification regulates interactions with:  Interacting molecule Interacting domains Effect Consequences (function) Consequences (process) Detection assays ADD3 (human) Disrupts pull-down assay Comments:  ADD3 stimulates SLC12A3 activity