Curated Information
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Home > Curated Information Page > PubMed Id: 21130744
Xie P, et al. (2011) ATM-mediated NuSAP phosphorylation induces mitotic arrest. Biochem Biophys Res Commun 404, 413-8 21130744
This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2015, 43:D512-20). To learn more about the scope of PhosphoSitePlus®, click here.
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S124-p - NUSAP1 (human)
Modsite: QNHEKQEsQDLRATA SwissProt Entrez-Gene
Orthologous residues
NUSAP1 (human): S124‑p, NUSAP1 iso2 (human): S124‑p, NUSAP1 (mouse): N128‑p, NUSAP1 (rat): N121‑p
Characterization
Methods used to characterize site in vivo immunoprecipitation, mutation of modification site, phospho-antibody, western blotting
Relevant cell lines - cell types - tissues:  HEK293T (epithelial)
Cellular systems studied:  cell lines
Species studied:  human
Upstream Regulation
Potential in vivo enzymes for site: 
Type Enzyme Evidence Notes
KINASE ATM (human) co-immunoprecipitation, pharmacological inhibitor of upstream enzyme, phospho-motif antibody, siRNA inhibition of enzyme
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
nocodazole increase
caffeine decrease
siRNA decrease siRNA ATM