Curated Information
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Home > Curated Information Page > PubMed Id: 20504934
Liu X, et al. (2010) Phorbol ester-induced human cytomegalovirus major immediate-early (MIE) enhancer activation through PKC-delta, CREB, and NF-kappaB desilences MIE gene expression in quiescently infected human pluripotent NTera2 cells. J Virol 84, 8495-508 20504934
This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2015, 43:D512-20). To learn more about the scope of PhosphoSitePlus®, click here.
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S63-p - ATF-1 (human)
Modsite: GILARRPsyRKILkD SwissProt Entrez-Gene
Orthologous residues
ATF‑1 (human): S63‑p, ATF‑1 (mouse): S63‑p
Characterization
Methods used to characterize site in vivo phospho-antibody, western blotting
Disease tissue studied:  testicular cancer
Relevant cell lines - cell types - tissues:  NT2 (testicular)
Cellular systems studied:  cell lines
Species studied:  human
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
virus infection no change compared to control HCMV
VIP, virus infection increase
phorbol_ester, virus infection no change compared to control

S133-p - CREB (human)
Modsite: EILsRRPsyRkILND SwissProt Entrez-Gene
Orthologous residues
CREB (human): S133‑p, CREB iso2 (human): S119‑p, CREB (mouse): S133‑p, CREB (rat): S133‑p
Characterization
Methods used to characterize site in vivo phospho-antibody, western blotting
Disease tissue studied:  testicular cancer
Relevant cell lines - cell types - tissues:  NT2 (testicular)
Cellular systems studied:  cell lines
Species studied:  human
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
virus infection increase HCMV
VIP virus infection augment treatment-induced increase
phorbol_ester virus infection no effect upon treatment-induced increase
bisindolylmaleimide_II phorbol_ester no effect upon treatment-induced increase

T507-p - PKCD (human)
Modsite: FGEsRAstFCGtPDy SwissProt Entrez-Gene
Orthologous residues
PKCD (human): T507‑p, PKCD iso2 (human): T538‑p, PKCD (mouse): T505‑p, PKCD iso2 (mouse): T531‑p, PKCD (rat): T505‑p
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
phorbol_ester, virus infection increase human cytomegalovirus (HCMV)

S171-p - TORC2 (human)
Modsite: sALNRtssDsALHtS SwissProt Entrez-Gene
Orthologous residues
TORC2 (human): S171‑p, TORC2 (mouse): S171‑p, TORC2 (rat): S171‑p
Characterization
Methods used to characterize site in vivo phospho-antibody, western blotting
Disease tissue studied:  testicular cancer
Relevant cell lines - cell types - tissues:  NT2 (testicular)
Cellular systems studied:  cell lines
Species studied:  human
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
virus infection increase
VIP virus infection augment treatment-induced increase
phorbol_ester virus infection inhibit treatment-induced increase