Curated Information
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Home > Curated Information Page > PubMed Id: 11114888
Tibbetts RS, et al. (2000) Functional interactions between BRCA1 and the checkpoint kinase ATR during genotoxic stress. Genes Dev 14, 2989-3002 11114888
This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2015, 43:D512-20). To learn more about the scope of PhosphoSitePlus®, click here.
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S1143-p - BRCA1 (human)
Modsite: PMGSSHAsQVCSETP SwissProt Entrez-Gene
Orthologous residues
BRCA1 (human): S1143‑p, BRCA1 iso6 (human): , BRCA1 iso7 (human): S1143‑p, BRCA1 (mouse): F1106‑p, BRCA1 (rat): F1107‑p

S1280-p - BRCA1 (human)
Modsite: QVILAkAsQEHHLsE SwissProt Entrez-Gene
Orthologous residues
BRCA1 (human): S1280‑p, BRCA1 iso6 (human): , BRCA1 iso7 (human): S1280‑p, BRCA1 (mouse): S1241‑p, BRCA1 (rat): S1242‑p

S1423-p - BRCA1 (human)
Modsite: AVLEQHGsQPSNSYP SwissProt Entrez-Gene
Orthologous residues
BRCA1 (human): S1423‑p, BRCA1 iso6 (human): S320‑p, BRCA1 iso7 (human): S1423‑p, BRCA1 (mouse): N1379‑p, BRCA1 (rat): S1380‑p
Characterization
Methods used to characterize site in vivo mutation of modification site, phospho-antibody
Relevant cell lines - cell types - tissues:  HEK293T (epithelial)
Cellular systems studied:  cell lines
Species studied:  human
Enzymes shown to modify site in vitro
Type Enzyme
KINASE ATR (human)
Upstream Regulation
Potential in vivo enzymes for site: 
Type Enzyme Evidence Notes
KINASE ATR (human) phospho-antibody, transfection of inactive enzyme
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
ionizing_radiation increase
UV increase
hydroxyurea increase
aphidicolin increase