Curated Information
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Home > Curated Information Page > PubMed Id: 8955135
Li J, Smithgall TE (1996) Co-expression with BCR induces activation of the FES tyrosine kinase and phosphorylation of specific N-terminal BCR tyrosine residues. J Biol Chem 271, 32930-6 8955135
This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2015, 43:D512-20). To learn more about the scope of PhosphoSitePlus®, click here.
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Y177-p - Bcr (human)
Modsite: ADAEKPFyVNVEFHH SwissProt Entrez-Gene
Orthologous residues
Bcr (human): Y177‑p, Bcr iso2 (human): Y177‑p, Bcr (mouse): Y178‑p, Bcr (rat): Y178‑p
Characterization
Methods used to characterize site in vivo [32P] bio-synthetic labeling, mutation of modification site, phosphopeptide mapping
Relevant cell lines - cell types - tissues:  HEK293T (epithelial)
Cellular systems studied:  cell lines
Species studied:  human
Downstream Regulation
Effect of modification (function):  molecular association, regulation
Modification regulates interactions with: 
Interacting molecule Interacting domains Effect Consequences (function) Consequences (process) Detection assays
GRB2 (human) SH2 Induces

Y246-p - Bcr (human)
Modsite: sCGVDGDyEDAELNP SwissProt Entrez-Gene
Orthologous residues
Bcr (human): Y246‑p, Bcr iso2 (human): Y246‑p, Bcr (mouse): Y247‑p, Bcr (rat): Y247‑p
Characterization
Methods used to characterize site in vivo [32P] bio-synthetic labeling, mutation of modification site, phosphopeptide mapping
Relevant cell lines - cell types - tissues:  HEK293T (epithelial)
Cellular systems studied:  cell lines
Species studied:  human
Enzymes shown to modify site in vitro
Type Enzyme
KINASE Fes (human)

Y276-p - Bcr (human)
Modsite: PPWPPLEyQPyQsIy SwissProt Entrez-Gene
Orthologous residues
Bcr (human): Y276‑p, Bcr iso2 (human): Y276‑p, Bcr (mouse): Y277‑p, Bcr (rat): Y277‑p
Characterization
Methods used to characterize site in vivo [32P] bio-synthetic labeling, mutation of modification site, phosphopeptide mapping
Relevant cell lines - cell types - tissues:  HEK293T (epithelial)
Cellular systems studied:  cell lines
Species studied:  human
Comments:  one or more sites in cluster (Y276, Y279, Y283) are phosphorylated

Y279-p - Bcr (human)
Modsite: PPLEyQPyQsIyVGG SwissProt Entrez-Gene
Orthologous residues
Bcr (human): Y279‑p, Bcr iso2 (human): Y279‑p, Bcr (mouse): Y280‑p, Bcr (rat): Y280‑p
Characterization
Methods used to characterize site in vivo [32P] bio-synthetic labeling, mutation of modification site, phosphopeptide mapping
Relevant cell lines - cell types - tissues:  HEK293T (epithelial)
Cellular systems studied:  cell lines
Species studied:  human
Comments:  one or more sites in cluster (Y276, Y279, Y283) are phosphorylated

Y283-p - Bcr (human)
Modsite: yQPyQsIyVGGMMEG SwissProt Entrez-Gene
Orthologous residues
Bcr (human): Y283‑p, Bcr iso2 (human): Y283‑p, Bcr (mouse): Y284‑p, Bcr (rat): Y284‑p
Characterization
Methods used to characterize site in vivo [32P] bio-synthetic labeling, mutation of modification site, phosphopeptide mapping
Relevant cell lines - cell types - tissues:  HEK293T (epithelial)
Cellular systems studied:  cell lines
Species studied:  human
Comments:  one or more sites in cluster (Y276, Y279, Y283) are phosphorylated