Pham CD, et al. (1995) Characterization of MEK1 phosphorylation by the v-Mos protein. Oncogene 10, 1683-8 7731726

This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2015, 43:D512-20). To learn more about the scope of PhosphoSitePlus®, click here.

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S218-p - MEK1 (human) ▲
Modsite: VsGQLIDsMANsFVG SwissProt Entrez-Gene Orthologous residues MEK1 (human): S218‑p, MEK1 iso2 (human): S192‑p, MEK1 (mouse): S218‑p, MEK1 (rat): S218‑p, MEK1 (rabbit): S218‑p Characterization Enzymes shown to modify site in vitro:  Type Enzyme KINASE MOS (mouse) Downstream Regulation Effect of modification (function):  enzymatic activity, induced

S222-p - MEK1 (human) ▲
Modsite: LIDsMANsFVGtRSY SwissProt Entrez-Gene Orthologous residues MEK1 (human): S222‑p, MEK1 iso2 (human): S196‑p, MEK1 (mouse): S222‑p, MEK1 (rat): S222‑p, MEK1 (rabbit): S222‑p Characterization Enzymes shown to modify site in vitro:  Type Enzyme KINASE MOS (mouse) Downstream Regulation Effect of modification (function):  enzymatic activity, induced

S218-p - MEK1 (mouse) ▲

Modsite: VSGQLIDsMANsFVG SwissProt Entrez-Gene Orthologous residues MEK1 (human): S218‑p, MEK1 iso2 (human): S192‑p, MEK1 (mouse): S218‑p, MEK1 (rat): S218‑p, MEK1 (rabbit): S218‑p Characterization Methods used to characterize site in vivo:  [32P] bio-synthetic labeling, phosphopeptide mapping Relevant cell lines - cell types - tissues:  3T3 (fibroblast) [MOS (mouse)], 3T3 (fibroblast) [SHP-2 (mouse), homozygous knockout] Cellular systems studied:  cell lines Species studied:  mouse Downstream Regulation Effect of modification (function):  enzymatic activity, induced

S222-p - MEK1 (mouse) ▲

Modsite: LIDsMANsFVGTRSY SwissProt Entrez-Gene Orthologous residues MEK1 (human): S222‑p, MEK1 iso2 (human): S196‑p, MEK1 (mouse): S222‑p, MEK1 (rat): S222‑p, MEK1 (rabbit): S222‑p Characterization Methods used to characterize site in vivo:  [32P] bio-synthetic labeling, phosphopeptide mapping Relevant cell lines - cell types - tissues:  3T3 (fibroblast) [MOS (mouse)], 3T3 (fibroblast) [SHP-2 (mouse), homozygous knockout] Cellular systems studied:  cell lines Species studied:  mouse Downstream Regulation Effect of modification (function):  enzymatic activity, induced