Curated Information
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Home > Curated Information Page > PubMed Id: 20920494
Leverence JT, Medhora M, Konduri GG, Sampath V (2011) Lipopolysaccharide-induced cytokine expression in alveolar epithelial cells: role of PKCĪ¶-mediated p47phox phosphorylation. Chem Biol Interact 189, 72-81 20920494
This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2015, 43:D512-20). To learn more about the scope of PhosphoSitePlus®, click here.
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S304-p - p47phox (human)
Modsite: GAPPRRssIRNAHsI SwissProt Entrez-Gene
Orthologous residues
p47phox (human): S304‑p, p47phox (mouse): T305‑p, p47phox (rat): T305‑p
Upstream Regulation
Potential in vivo enzymes for site: 
Type Enzyme Evidence Notes
KINASE PKCZ (human) pharmacological inhibitor of upstream enzyme, pharmacological activator of upstream enzyme
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
LPS increase
rottlerin LPS no effect upon treatment-induced increase
calphostin_C LPS no effect upon treatment-induced increase
PKC-zeta_inhibitor LPS inhibit treatment-induced increase
LPS increase
Downstream Regulation
Effect of modification (function):  intracellular localization

T410-p - PKCZ (human)
Modsite: GPGDtTstFCGtPNy SwissProt Entrez-Gene
Orthologous residues
PKCZ (human): T410‑p, PKCZ iso2 (human): T227‑p, PKCZ iso3 (human): T306‑p, PKCZ (mouse): T410‑p, PKCZ (rat): T410‑p