Zheng XM, Resnick RJ, Shalloway D (2000) A phosphotyrosine displacement mechanism for activation of Src by PTPalpha. EMBO J 19, 964-78 10698938

This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2015, 43:D512-20). To learn more about the scope of PhosphoSitePlus®, click here.

Click on the protein name to open the protein page, and on the RSD number to open the site page.

Download

Y789-p - PTPRA iso6 (human) ▲

Modsite: yIDAFSDyANFK___ SwissProt Entrez-Gene Orthologous residues PTPRA (human): Y798‑p, PTPRA iso6 (human): Y789‑p, PTPRA (mouse): Y825‑p, PTPRA (rat): Y792‑p Characterization Methods used to characterize site in vivo:  mutation of modification site, phospho-antibody Relevant cell lines - cell types - tissues:  3T3 (fibroblast) [SHP-2 (mouse), homozygous knockout] Cellular systems studied:  cell lines Species studied:  mouse Upstream Regulation Treatments, proteins and their effect on site modification:  Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes EDTA decrease Downstream Regulation Effect of modification (function):  molecular association, regulation Modification regulates interactions with:  Interacting molecule Interacting domains Effect Consequences (function) Consequences (process) Detection assays Src (chicken) Induces activity, induced in vitro, functional assay, co-immunoprecipitation Comments:  PTP-alpha binding to Src via Y527 allows dephosphorylation of this residue.

Y527-p - Src (chicken) ▲
Modsite: FTSTEPQyQPGENL_ SwissProt Entrez-Gene Orthologous residues Src (human): Y530‑p, Src iso2 (human): Y536‑p, Src (mouse): Y529‑p, Src iso1 (mouse): Y535‑p, Src (rat): Y530‑p, Src (chicken): Y527‑p Characterization Enzymes shown to modify site in vitro:  Type Enzyme PHOSPHATASE PTPRA (human)