Curated Information
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Home > Curated Information Page > PubMed Id: 20962898
Glover M, Mercier Zuber A, Figg N, O'Shaughnessy KM (2010) The activity of the thiazide-sensitive Na(+)-Cl⁻ cotransporter is regulated by protein phosphatase PP4. Can J Physiol Pharmacol 88, 986-95 20962898
This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2015, 43:D512-20). To learn more about the scope of PhosphoSitePlus®, click here.
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T58-p - NCCT (mouse)
Modsite: MRtFGYNtIDVVPAY SwissProt Entrez-Gene
Orthologous residues
NCCT (human): T60‑p, NCCT iso2 (human): T60‑p, NCCT iso3 (human): T60‑p, NCCT (mouse): T58‑p, NCCT (rat): T58‑p
Characterization
Methods used to characterize site in vivo mutation of modification site
Relevant cell lines - cell types - tissues:  oocyte
Cellular systems studied:  primary cells
Species studied:  frog
Upstream Regulation
Potential in vivo enzymes for site: 
Type Enzyme Evidence Notes
PHOSPHATASE PPP4C (human) transfection of wild-type enzyme, transfection of inactive enzyme
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
fostriecin increase
Downstream Regulation
Effect of modification (function):  activity, induced