Curated Information
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Home > Curated Information Page > PubMed Id: 31622781
Greer-Short A, et al. (2019) Calmodulin kinase II regulates atrial myocyte late sodium current, calcium handling, and atrial arrhythmia. Heart Rhythm 31622781
This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2015, 43:D512-20). To learn more about the scope of PhosphoSitePlus®, click here.
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S571-p - SCN5A (human)
Modsite: PWPLRRtsAQGQPsP SwissProt Entrez-Gene
Orthologous residues
SCN5A (human): S571‑p, SCN5A (mouse): S571‑p, SCN5A (rat): S572‑p
Upstream Regulation
Potential in vivo enzymes for site: 
Type Enzyme Evidence Notes
KINASE CAMK2A (human) autophosphorylation
Downstream Regulation
Effect of modification (function):  activity, induced, enzymatic activity, induced
Comments:  Induce and regulate Atrial fibrillation, increase calcium mediated arrhythmia and regulates atrial myocyte late Na current and membrane excitability
Associated Diseases
Diseases Alterations Comments
atrial fibrillation increased

S571-p - SCN5A (mouse)
Modsite: PWPLRRPsTQGQPGF SwissProt Entrez-Gene
Orthologous residues
SCN5A (human): S571‑p, SCN5A (mouse): S571‑p, SCN5A (rat): S572‑p
Upstream Regulation
Potential in vivo enzymes for site: 
Type Enzyme Evidence Notes
KINASE CAMK2A (human) autophosphorylation
Downstream Regulation
Effect of modification (function):  activity, induced, enzymatic activity, induced
Comments:  Induce and regulate Atrial fibrillation, increase calcium mediated arrhythmia and regulates atrial myocyte late Na current and membrane excitability