Wang J, Liu J, Ji X, Zhang X (2019) Tyr198 is the Essential Autophosphorylation Site for STK16 Localization and Kinase Activity. Int J Mol Sci 20 31574902

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T185-p - MPSK1 (human) ▲
Modsite: EGSRQALtLQDWAAQ SwissProt Entrez-Gene Orthologous residues MPSK1 (human): T185‑p, MPSK1 (mouse): A185‑p, MPSK1 (rat): A185‑p Characterization Methods used to characterize site in vivo:  mutation of modification site Relevant cell lines - cell types - tissues:  HeLa (cervical) Cellular systems studied:  cell lines Species studied:  human

S197-p - MPSK1 (human) ▲
Modsite: AAQRCTIsyRAPELF SwissProt Entrez-Gene Orthologous residues MPSK1 (human): S197‑p, MPSK1 (mouse): S197‑p, MPSK1 (rat): S197‑p Characterization Methods used to characterize site in vivo:  mutation of modification site Relevant cell lines - cell types - tissues:  HeLa (cervical) Cellular systems studied:  cell lines Species studied:  human

Y198-p - MPSK1 (human) ▲

Modsite: AQRCTIsyRAPELFS SwissProt Entrez-Gene Orthologous residues MPSK1 (human): Y198‑p, MPSK1 (mouse): Y198‑p, MPSK1 (rat): Y198‑p Characterization Methods used to characterize site in vivo:  mutation of modification site Relevant cell lines - cell types - tissues:  HeLa (cervical) Cellular systems studied:  cell lines Species studied:  human Upstream Regulation Potential in vivo enzymes for site:  Type Enzyme Evidence Notes KINASE MPSK1 (human) Autophosphorylation Downstream Regulation Effect of modification (function):  enzymatic activity, induced, intracellular localization, phosphorylation Effect of modification (process):  cell cycle regulation Comments:  decrease 4EBP1 phosphorylation by Y198 mutation