Curated Information
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Home > Curated Information Page > PubMed Id: 9368070
Ito H, et al. (1997) Phosphorylation of alphaB-crystallin in response to various types of stress. J Biol Chem 272, 29934-41 9368070
This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2015, 43:D512-20). To learn more about the scope of PhosphoSitePlus®, click here.
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S19-p - CRYAB (human)
Modsite: RPFFPFHsPsrLFDQ SwissProt Entrez-Gene
Orthologous residues
CRYAB (human): S19‑p, CRYAB (mouse): S19‑p, CRYAB (rat): S19‑p, CRYAB (rabbit): S19‑p, CRYAB (pig): S19‑p, CRYAB (cow): S19‑p
Characterization
Methods used to characterize site in vivo [32P] bio-synthetic labeling, mass spectrometry, phospho-antibody
Disease tissue studied:  brain cancer, astrocytoma
Relevant cell lines - cell types - tissues:  U373 MG (glial)
Cellular systems studied:  cell lines
Species studied:  human

S45-p - CRYAB (human)
Modsite: FPTSTsLsPFYLrPP SwissProt Entrez-Gene
Orthologous residues
CRYAB (human): S45‑p, CRYAB (mouse): S45‑p, CRYAB (rat): S45‑p, CRYAB (rabbit): S45‑p, CRYAB (pig): S45‑p, CRYAB (cow): S45‑p
Characterization
Methods used to characterize site in vivo [32P] bio-synthetic labeling, mass spectrometry, phospho-antibody
Disease tissue studied:  brain cancer, astrocytoma
Relevant cell lines - cell types - tissues:  U373 MG (glial)
Cellular systems studied:  cell lines
Species studied:  human
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
arsenite increase
phorbol_ester increase S45 remains heavily phosphorylated after 90 min of PMA treatment, but modestly phosphorylated after arsenite treatment.
H2O2 increase
anisomycin increase
heat_shock increase

S59-p - CRYAB (human)
Modsite: PsFLRAPsWFDTGLS SwissProt Entrez-Gene
Orthologous residues
CRYAB (human): S59‑p, CRYAB (mouse): S59‑p, CRYAB (rat): S59‑p, CRYAB (rabbit): S59‑p, CRYAB (pig): S59‑p, CRYAB (cow): S59‑p
Characterization
Methods used to characterize site in vivo [32P] bio-synthetic labeling, mass spectrometry, phospho-antibody
Disease tissue studied:  brain cancer, astrocytoma
Relevant cell lines - cell types - tissues:  U373 MG (glial)
Cellular systems studied:  cell lines
Species studied:  human
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
arsenite increase
H2O2 increase
anisomycin increase
heat_shock increase