Curated Information
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Home > Curated Information Page > PubMed Id: 9636152
Malek SN, et al. (1998) Malignant transformation of early lymphoid progenitors in mice expressing an activated Blk tyrosine kinase. Proc Natl Acad Sci U S A 95, 7351-6 9636152
This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2015, 43:D512-20). To learn more about the scope of PhosphoSitePlus®, click here.
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Y495-p - BLK (mouse)
Modsite: YTATEGQyELQP___ SwissProt Entrez-Gene
Orthologous residues
BLK (human): Y501‑p, BLK (mouse): Y495‑p, BLK (rat): Y495‑p
Downstream Regulation
Effect of modification (function):  enzymatic activity, inhibited
Effect of modification (process):  cell growth, altered
Comments:  Constitutively active mutant developed lymphomas. Tyrosine phosphorylated proteins such as PLC-gamma and PI3K, were seen in tumors.