Curated Information
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Home > Curated Information Page > PubMed Id: 31533340
Legartová S, et al. (2019) DNA Damage Changes Distribution Pattern and Levels of HP1 Protein Isoforms in the Nucleolus and Increases Phosphorylation of HP1β-Ser88. Cells 8 31533340
This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2015, 43:D512-20). To learn more about the scope of PhosphoSitePlus®, click here.
Information from this record has been curated, but not yet edited in PhosphoSitePlus® and may be incomplete.
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S89-p - CBX1 (human)
Modsite: GGkRKADsDsEDKGE SwissProt Entrez-Gene
Orthologous residues
CBX1 (human): S89‑p, CBX1 (mouse): S89‑p, CBX1 (rat): S89‑p
Characterization
Methods used to characterize site in vivo mass spectrometry
Relevant cell lines - cell types - tissues:  HeLa (cervical)
Cellular systems studied:  cell lines
Species studied:  human
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
ionizing_radiation increase
vorinostat increase

S91-p - CBX1 (human)
Modsite: kRKADsDsEDKGEEs SwissProt Entrez-Gene
Orthologous residues
CBX1 (human): S91‑p, CBX1 (mouse): S91‑p, CBX1 (rat): S91‑p
Characterization
Methods used to characterize site in vivo mass spectrometry
Relevant cell lines - cell types - tissues:  HeLa (cervical)
Cellular systems studied:  cell lines
Species studied:  human
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
ionizing_radiation no change compared to control
vorinostat no change compared to control

S162-p - CBX1 (human)
Modsite: kCPQVVIsFyEERLT SwissProt Entrez-Gene
Orthologous residues
CBX1 (human): S162‑p, CBX1 (mouse): S162‑p, CBX1 (rat): S162‑p
Characterization
Methods used to characterize site in vivo mass spectrometry
Relevant cell lines - cell types - tissues:  HeLa (cervical)
Cellular systems studied:  cell lines
Species studied:  human
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
ionizing_radiation no change compared to control
vorinostat no change compared to control

Y164-p - CBX1 (human)
Modsite: PQVVIsFyEERLTWH SwissProt Entrez-Gene
Orthologous residues
CBX1 (human): Y164‑p, CBX1 (mouse): Y164‑p, CBX1 (rat): Y164‑p
Characterization
Methods used to characterize site in vivo mass spectrometry
Relevant cell lines - cell types - tissues:  HeLa (cervical)
Cellular systems studied:  cell lines
Species studied:  human
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
ionizing_radiation no change compared to control
vorinostat no change compared to control

S172-p - CBX1 (human)
Modsite: EERLTWHsyPsEDDD SwissProt Entrez-Gene
Orthologous residues
CBX1 (human): S172‑p, CBX1 (mouse): S172‑p, CBX1 (rat): S172‑p
Characterization
Methods used to characterize site in vivo mass spectrometry
Relevant cell lines - cell types - tissues:  HeLa (cervical)
Cellular systems studied:  cell lines
Species studied:  human
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
ionizing_radiation no change compared to control
vorinostat no change compared to control

S175-p - CBX1 (human)
Modsite: LTWHsyPsEDDDkkD SwissProt Entrez-Gene
Orthologous residues
CBX1 (human): S175‑p, CBX1 (mouse): S175‑p, CBX1 (rat): S175‑p
Characterization
Methods used to characterize site in vivo mass spectrometry
Relevant cell lines - cell types - tissues:  HeLa (cervical)
Cellular systems studied:  cell lines
Species studied:  human
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
ionizing_radiation no change compared to control
vorinostat no change compared to control