Curated Information
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Home > Curated Information Page > PubMed Id: 19525936
Peng G, et al. (2009) BRIT1/MCPH1 links chromatin remodelling to DNA damage response. Nat Cell Biol 11, 865-72 19525936
This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2015, 43:D512-20). To learn more about the scope of PhosphoSitePlus®, click here.
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S969-p - SMARCC2 (human)
Modsite: PPALPPGsQPIPPTG SwissProt Entrez-Gene
Orthologous residues
SMARCC2 (human): S969‑p, SMARCC2 iso2 (human): S1000‑p, SMARCC2 (mouse): S969‑p, SMARCC2 (rat): S1000‑p, SMARCC2 (cow): S1000‑p
Methods used to characterize site in vivo immunoprecipitation, mutation of modification site, phospho-antibody, western blotting
Disease tissue studied:  bone cancer
Relevant cell lines - cell types - tissues:  HEK293T (epithelial), U2OS (bone cell)
Cellular systems studied:  cell lines
Species studied:  human
Enzymes shown to modify site in vitro
Type Enzyme
KINASE ATM (human)
KINASE ATR (human)
Downstream Regulation
Effect of modification (function):  molecular association, regulation
Effect of modification (process):  chromatin organization, altered
Modification regulates interactions with: 
Interacting molecule Interacting domains Effect Consequences (function) Consequences (process) Detection assays
MCPH1 (human) Induces co-immunoprecipitation
Comments:  interaction enhanced after DNA damage with ionizing radiation