Curated Information
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Home > Curated Information Page > PubMed Id: 31413112
Guadall A, et al. (2019) Dimerization and phosphorylation of Lutheran/basal cell adhesion molecule are critical for its function in cell migration on laminin. J Biol Chem 31413112
This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2015, 43:D512-20). To learn more about the scope of PhosphoSitePlus®, click here.
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S621-p - Lu (human)
Modsite: sGGARGGsGGFGDEC SwissProt Entrez-Gene
Orthologous residues
Lu (human): S621‑p, Lu (mouse): S615‑p, Lu (rat): N617‑p
Upstream Regulation
Potential in vivo enzymes for site: 
Type Enzyme Evidence Notes
KINASE PKACA (human) pharmacological inhibitor of upstream enzyme
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
H-89 decrease
Akt-I-1 increase
DMSO increase
Downstream Regulation
Effect of modification (function):  molecular association, regulation
Effect of modification (process):  cell adhesion, induced, cell motility, induced
Modification regulates interactions with: 
Interacting molecule Interacting domains Effect Consequences (function) Consequences (process) Detection assays
Lu (human) Induces FRET
Comments:  Dimerization of Lu, induce cell migration on Lamnin 521.