Curated Information
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Home > Curated Information Page > PubMed Id: 20305697
Xu Y, et al. (2010) Role of CK1 in GSK3beta-mediated phosphorylation and degradation of snail. Oncogene 29, 3124-33 20305697
This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2015, 43:D512-20). To learn more about the scope of PhosphoSitePlus®, click here.
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S96-p - Snail1 (human)
Modsite: TsLsDEDsGKGsQPP SwissProt Entrez-Gene
Orthologous residues
Snail1 (human): S96‑p, Snail1 (mouse): S96‑p
Characterization
Enzymes shown to modify site in vitro
Type Enzyme
KINASE GSK3B (human)
Comments:  prior phosphorylation of S104 and S107 by CK1 allows GSK3B phosphorylation of S96 and S100

S100-p - Snail1 (human)
Modsite: DEDsGKGsQPPsPPs SwissProt Entrez-Gene
Orthologous residues
Snail1 (human): S100‑p, Snail1 (mouse): S100‑p
Characterization
Enzymes shown to modify site in vitro
Type Enzyme
KINASE GSK3B (human)
Comments:  prior phosphorylation of S104 and S107 by CK1 allows GSK3B phosphorylation of S96 and S100

S104-p - Snail1 (human)
Modsite: GKGsQPPsPPsPAPs SwissProt Entrez-Gene
Orthologous residues
Snail1 (human): S104‑p, Snail1 (mouse): S104‑p
Characterization
Enzymes shown to modify site in vitro
Type Enzyme
KINASE CK1E (human)
Downstream Regulation
Effect of modification (function):  protein degradation, ubiquitination
Comments:  in vitro

S107-p - Snail1 (human)
Modsite: sQPPsPPsPAPssFS SwissProt Entrez-Gene
Orthologous residues
Snail1 (human): S107‑p, Snail1 (mouse): S107‑p
Characterization
Enzymes shown to modify site in vitro
Type Enzyme
KINASE CK1E (human)
Downstream Regulation
Effect of modification (function):  protein degradation, ubiquitination
Comments:  in vitro