Curated Information
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Home > Curated Information Page > PubMed Id: 20057499
Niikura Y, Ogi H, Kikuchi K, Kitagawa K (2010) BUB3 that dissociates from BUB1 activates caspase-independent mitotic death (CIMD). Cell Death Differ 17, 1011-24 20057499
This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2015, 43:D512-20). To learn more about the scope of PhosphoSitePlus®, click here.
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S19-p - BUB3 (human)
Modsite: PPEDGISsVkFSPNT SwissProt Entrez-Gene
Orthologous residues
BUB3 (human): S19‑p, BUB3 iso2 (human): S19‑p, BUB3 (mouse): S19‑p, BUB3 (rat): S19‑p
Characterization
Methods used to characterize site in vivo mass spectrometry (in vitro), mutation of modification site, phospho-antibody, western blotting
Cellular systems studied:  cell lines
Species studied:  human
Enzymes shown to modify site in vitro
Type Enzyme
KINASE BUB1 (human)
Downstream Regulation
Effect of modification (process):  apoptosis, induced
Comments:  caspase-independent mitotic death (CIMD)

Y99-p - p73 (human)
Modsite: SVPTHSPyAQPSSTF SwissProt Entrez-Gene
Orthologous residues
p73 (human): Y99‑p, p73 iso2 (human): Y99‑p, p73 iso8 (human): Y50‑p, p73 iso10 (human): Y50‑p, p73 (mouse): Y91‑p
Characterization
Methods used to characterize site in vivo immunoprecipitation, mutation of modification site, phospho-antibody, western blotting
Relevant cell lines - cell types - tissues:  HeLa (cervical)
Cellular systems studied:  cell lines
Species studied:  human
Downstream Regulation
Effect of modification (process):  apoptosis, induced
Modification regulates interactions with: 
Interacting molecule Interacting domains Effect Consequences (function) Consequences (process) Detection assays
BUB3 (human) Induces apoptosis, altered co-immunoprecipitation
Comments:  caspase-independent mitotic death (CIMD)