Bagheri-Yarmand R, et al. (2010) Cyclin E deregulation impairs mitotic progression through premature activation of Cdc25C. Cancer Res 70, 5085-95 20530684

This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2015, 43:D512-20). To learn more about the scope of PhosphoSitePlus®, click here.

Click on the protein name to open the protein page, and on the RSD number to open the site page.

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S214-p - CDC25C (human) ▲

Modsite: sRsGLyRsPsMPENL SwissProt Entrez-Gene Orthologous residues CDC25C (human): S214‑p, CDC25C iso3 (human): S171‑p, CDC25C (mouse): ‑, CDC25C (frog): S285‑p Characterization Methods used to characterize site in vivo:  mutation of modification site, western blotting Relevant cell lines - cell types - tissues:  HeLa (cervical) Cellular systems studied:  cell lines Species studied:  human Upstream Regulation Potential in vivo enzymes for site:  Type Enzyme Evidence Notes KINASE CDK2 (human) co-immunoprecipitation, pharmacological inhibitor of upstream enzyme, activation of upstream enzyme, mutation in upstream enzyme recognition motif Comments:  cyclin E/CDK2 Downstream Regulation Effect of modification (function):  enzymatic activity, induced

S216-p - CDC25C (human) ▲
Modsite: sGLyRsPsMPENLNR SwissProt Entrez-Gene Orthologous residues CDC25C (human): S216‑p, CDC25C iso3 (human): S173‑p, CDC25C (mouse): ‑, CDC25C (frog): S287‑p Characterization Methods used to characterize site in vivo:  mutation of modification site, western blotting Relevant cell lines - cell types - tissues:  HeLa (cervical) Cellular systems studied:  cell lines Species studied:  human

Y15-p - CDK1 (human) ▲

Modsite: EkIGEGtyGVVykGR SwissProt Entrez-Gene Orthologous residues CDK1 (human): Y15‑p, CDK1 iso2 (human): Y15‑p, CDK1 (mouse): Y15‑p, CDK1 (rat): Y15‑p, CDK1 (chicken): Y15‑p, CDK1 (fruit fly): Y15‑p Characterization Methods used to characterize site in vivo:  phospho-antibody, western blotting Relevant cell lines - cell types - tissues:  HeLa (cervical) Cellular systems studied:  cell lines Species studied:  human Upstream Regulation Treatments, proteins and their effect on site modification:  Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes CCNE1 (human) decrease