Curated Information
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Home > Curated Information Page > PubMed Id: 31353306
Ko YU, et al. (2019) Protein kinase A-induced phosphorylation at the Thr154 affects stability of DJ-1. Parkinsonism Relat Disord 31353306
This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2015, 43:D512-20). To learn more about the scope of PhosphoSitePlus®, click here.
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T154-p - DJ-1 (human)
Modsite: EkDGLILtSRGPGTS SwissProt Entrez-Gene
Orthologous residues
DJ‑1 (human): T154‑p, DJ‑1 (mouse): T154‑p, DJ‑1 (rat): T154‑p
Methods used to characterize site in vivo mass spectrometry, phospho-antibody, western blotting
Relevant cell lines - cell types - tissues:  293 (epithelial), brain, MN9D ('neuron, mesencephalic')
Cellular systems studied:  cell lines, tissue
Species studied:  human, mouse
Enzymes shown to modify site in vitro
Type Enzyme
Upstream Regulation
Potential in vivo enzymes for site: 
Type Enzyme Evidence Notes
KINASE PKACA (human) co-immunoprecipitation, transfection of wild-type enzyme, microscopy-colocalization
Downstream Regulation
Effect of modification (function):  intracellular localization, molecular association, regulation, protein stabilization
Modification regulates interactions with: 
Interacting molecule Interacting domains Effect Consequences (function) Consequences (process) Detection assays
DJ-1 (human) Induces photo-crosslinking, co-immunoprecipitation