Peng C, et al. (2010) RSK2 mediates NF-{kappa}B activity through the phosphorylation of IkappaBalpha in the TNF-R1 pathway. FASEB J 24, 3490-9 20385620

This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2015, 43:D512-20). To learn more about the scope of PhosphoSitePlus®, click here.

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S32-p - IkB-alpha (human) ▲

Modsite: LLDDRHDsGLDsMkD SwissProt Entrez-Gene Orthologous residues IkB‑alpha (human): S32‑p, IkB‑alpha (mouse): S32‑p, IkB‑alpha (rat): S32‑p Characterization Enzymes shown to modify site in vitro:  Type Enzyme KINASE RSK2 (human) Upstream Regulation Potential in vivo enzymes for site:  Type Enzyme Evidence Notes KINASE RSK2 (human) siRNA inhibition of enzyme, phospho-motif antibody, activation of upstream enzyme, phospho-antibody, co-immunoprecipitation Treatments, proteins and their effect on site modification:  Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes TNF increase Downstream Regulation Effect of modification (function):  protein degradation Effect of modification (process):  apoptosis, inhibited, transcription, altered

S380-p - p90RSK (human) ▲
Modsite: HQLFRGFsFVAtGLM SwissProt Entrez-Gene Orthologous residues p90RSK (human): S380‑p, p90RSK iso2 (human): S389‑p, p90RSK (mouse): S369‑p, p90RSK iso3 (mouse): ‑, p90RSK (rat): S380‑p, p90RSK (chicken): S398‑p Upstream Regulation Treatments, proteins and their effect on site modification:  Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes TNF increase

S386-p - RSK2 (human) ▲
Modsite: HQLFRGFsFVAItsD SwissProt Entrez-Gene Orthologous residues RSK2 (human): S386‑p, RSK2 (mouse): S386‑p, RSK2 (rat): S386‑p, RSK2 (cow): S386‑p Upstream Regulation Treatments, proteins and their effect on site modification:  Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes TNF increase