Curated Information
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Home > Curated Information Page > PubMed Id: 20530479
Gasser A, et al. (2010) Two Nedd4-binding motifs underlie modulation of sodium channel Nav1.6 by p38 MAPK. J Biol Chem 285, 26149-61 20530479
This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2015, 43:D512-20). To learn more about the scope of PhosphoSitePlus®, click here.
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S553-p - SCN8A (mouse)
Modsite: SLLSIPGsPFLSRHN SwissProt Entrez-Gene
Orthologous residues
SCN8A (human): S553‑p, SCN8A iso3 (human): S553‑p, SCN8A (mouse): S553‑p, SCN8A (rat): S553‑p
Downstream Regulation
Effect of modification (function):  activity, inhibited, molecular association, regulation
Modification regulates interactions with: 
Interacting molecule Interacting domains Effect Consequences (function) Consequences (process) Detection assays
NEDD4L (human) Induces pull-down assay

Y1945-p - SCN8A (mouse)
Modsite: StASLPSyDsVtKPD SwissProt Entrez-Gene
Orthologous residues
SCN8A (human): Y1947‑p, SCN8A iso3 (human): Y1958‑p, SCN8A (mouse): Y1945‑p, SCN8A (rat): Y1945‑p
Characterization
Methods used to characterize site in vivo mutation of modification site
Relevant cell lines - cell types - tissues:  'neuron, hippocampal, CA1 pyramidal', 293 (epithelial)
Cellular systems studied:  cell lines, primary cultured cells
Species studied:  human, mouse
Downstream Regulation
Effect of modification (function):  activity, inhibited, molecular association, regulation
Modification regulates interactions with: 
Interacting molecule Interacting domains Effect Consequences (function) Consequences (process) Detection assays
NEDD4L (human) Induces pull-down assay