Ethell IM, et al. (2001) EphB/syndecan-2 signaling in dendritic spine morphogenesis. Neuron 31, 1001-13 11580899

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Y179-p - syndecan-2 (rat) ▲

Modsite: RKKDEGSyDLGERKP SwissProt Entrez-Gene Orthologous residues syndecan‑2 (human): Y179‑p, syndecan‑2 (mouse): Y180‑p, syndecan‑2 (rat): Y179‑p Characterization Methods used to characterize site in vivo:  mass spectrometry, mutation of modification site, phospho-antibody, western blotting Relevant cell lines - cell types - tissues:  'neuron, hippocampal'-brain, 293 (epithelial) Cellular systems studied:  cell lines, primary cultured cells Species studied:  human, rat Enzymes shown to modify site in vitro:  Type Enzyme KINASE EphB2 (human) Upstream Regulation Potential in vivo enzymes for site:  Type Enzyme Evidence Notes KINASE EphB2 (human) transfection of dominant-negative enzyme, microscopy-colocalization, transfection of wild-type enzyme, co-immunoprecipitation Downstream Regulation Effect of modification (function):  molecular association, regulation Effect of modification (process):  cytoskeletal reorganization Modification regulates interactions with:  Interacting molecule Interacting domains Effect Consequences (function) Consequences (process) Detection assays EphB2 (rat) Induces co-immunoprecipitation

Y191-p - syndecan-2 (rat) ▲

Modsite: RKPssAAyQKAPTKE SwissProt Entrez-Gene Orthologous residues syndecan‑2 (human): Y191‑p, syndecan‑2 (mouse): Y192‑p, syndecan‑2 (rat): Y191‑p Characterization Methods used to characterize site in vivo:  mass spectrometry, mutation of modification site, phospho-antibody, western blotting Relevant cell lines - cell types - tissues:  'neuron, hippocampal'-brain, 293 (epithelial) Cellular systems studied:  cell lines, primary cultured cells Species studied:  human, rat Enzymes shown to modify site in vitro:  Type Enzyme KINASE EphB2 (human) Upstream Regulation Potential in vivo enzymes for site:  Type Enzyme Evidence Notes KINASE EphB2 (human) transfection of dominant-negative enzyme, microscopy-colocalization, transfection of wild-type enzyme, co-immunoprecipitation Downstream Regulation Effect of modification (function):  molecular association, regulation Effect of modification (process):  cytoskeletal reorganization Modification regulates interactions with:  Interacting molecule Interacting domains Effect Consequences (function) Consequences (process) Detection assays EphB2 (rat) Induces co-immunoprecipitation