Curated Information
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Home > Curated Information Page > PubMed Id: 20538799
Nigro P, et al. (2010) PKCzeta decreases eNOS protein stability via inhibitory phosphorylation of ERK5. Blood 116, 1971-9 20538799
This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2015, 43:D512-20). To learn more about the scope of PhosphoSitePlus®, click here.
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K6-sm - ERK5 (mouse)
Modsite: __MAEPLkEEDGEDG SwissProt Entrez-Gene
Orthologous residues
ERK5 (human): K6‑sm, ERK5 iso2 (human): , ERK5 (mouse): K6‑sm, ERK5 (rat): K6‑sm
Characterization
Methods used to characterize site in vivo mutation of modification site
Relevant cell lines - cell types - tissues:  HUVEC (endothelial)
Cellular systems studied:  cell lines
Species studied:  human

K22-sm - ERK5 (mouse)
Modsite: GEPPGRVkAEPVHTA SwissProt Entrez-Gene
Orthologous residues
ERK5 (human): K22‑sm, ERK5 iso2 (human): , ERK5 (mouse): K22‑sm, ERK5 (rat): K22‑sm
Characterization
Methods used to characterize site in vivo mutation of modification site
Relevant cell lines - cell types - tissues:  HUVEC (endothelial)
Cellular systems studied:  cell lines
Species studied:  human

S486-p - ERK5 (mouse)
Modsite: LKAALLKsLRSRLRD SwissProt Entrez-Gene
Orthologous residues
ERK5 (human): S486‑p, ERK5 iso2 (human): S347‑p, ERK5 (mouse): S486‑p, ERK5 (rat): S486‑p
Characterization
Methods used to characterize site in vivo mutation of modification site
Relevant cell lines - cell types - tissues:  HUVEC (endothelial)
Cellular systems studied:  cell lines
Species studied:  human
Enzymes shown to modify site in vitro
Type Enzyme
KINASE PKCZ (human)