Sueyoshi T, et al. (2019) A phosphorylation-deficient mutant of retinoid X receptor α at Thr 167 alters fasting response and energy metabolism in mice. Lab Invest 31152145

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T167-p - RXRA (mouse) ▲

Modsite: CKGFFKRtVRKDLTY SwissProt Entrez-Gene Orthologous residues RXRA (human): T162‑p, RXRA (mouse): T167‑p, RXRA (rat): T167‑p Characterization Methods used to characterize site in vivo:  mutation of modification site, phospho-antibody, western blotting Disease tissue studied:  brain cancer, glioblastoma, glioma Relevant cell lines - cell types - tissues:  adipose tissue, liver, muscle, U87MG (glial) Cellular systems studied:  cell lines, tissue Species studied:  human, mouse Enzymes shown to modify site in vitro:  Type Enzyme KINASE PKCA (mouse) Upstream Regulation Treatments, proteins and their effect on site modification:  Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes fasting increase Downstream Regulation Effect of modification (process):  transcription, altered Comments:  regulation of energy (fatty acid) metabolism, glucose homeostasis