Curated Information
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Home > Curated Information Page > PubMed Id: 31189653
Solan JL, Marquez-Rosado L, Lampe PD (2019) Cx43 phosphorylation mediated effects on ERK and Akt protect against ischemia reperfusion injury and alter stability of stress-inducible protein NDRG1. J Biol Chem 31189653
This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2015, 43:D512-20). To learn more about the scope of PhosphoSitePlus®, click here.
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S262-p - GJA1 (mouse)
Modsite: sPskDCGsPkyAyFN SwissProt Entrez-Gene
Orthologous residues
GJA1 (human): S262‑p, GJA1 (mouse): S262‑p, GJA1 (rat): S262‑p, GJA1 (rabbit): S262‑p, GJA1 (pig): S262‑p, GJA1 (hamster): S262‑p, GJA1 (cow): S263‑p
Characterization
Methods used to characterize site in vivo phospho-antibody, western blotting
Relevant cell lines - cell types - tissues:  heart
Cellular systems studied:  tissue
Species studied:  mouse

S279-p - GJA1 (mouse)
Modsite: SsPtAPLsPMsPPGy SwissProt Entrez-Gene
Orthologous residues
GJA1 (human): S279‑p, GJA1 (mouse): S279‑p, GJA1 (rat): S279‑p, GJA1 (rabbit): S279‑p, GJA1 (pig): S279‑p, GJA1 (hamster): S279‑p, GJA1 (cow): S280‑p
Characterization
Methods used to characterize site in vivo phospho-antibody, western blotting
Relevant cell lines - cell types - tissues:  heart
Cellular systems studied:  tissue
Species studied:  mouse

S282-p - GJA1 (mouse)
Modsite: tAPLsPMsPPGykLV SwissProt Entrez-Gene
Orthologous residues
GJA1 (human): S282‑p, GJA1 (mouse): S282‑p, GJA1 (rat): S282‑p, GJA1 (rabbit): S282‑p, GJA1 (pig): S282‑p, GJA1 (hamster): S282‑p, GJA1 (cow): S283‑p
Characterization
Methods used to characterize site in vivo phospho-antibody, western blotting
Relevant cell lines - cell types - tissues:  heart
Cellular systems studied:  tissue
Species studied:  mouse

S325-p - GJA1 (mouse)
Modsite: NRMGQAGstIsNsHA SwissProt Entrez-Gene
Orthologous residues
GJA1 (human): S325‑p, GJA1 (mouse): S325‑p, GJA1 (rat): S325‑p, GJA1 (rabbit): S325‑p, GJA1 (pig): S325‑p, GJA1 (hamster): S325‑p, GJA1 (cow): S326‑p
Characterization
Methods used to characterize site in vivo mutation of modification site, phospho-antibody, western blotting
Relevant cell lines - cell types - tissues:  heart, MDCK (epithelial)
Cellular systems studied:  cell lines, tissue
Species studied:  dog, mouse

S328-p - GJA1 (mouse)
Modsite: GQAGstIsNsHAQPF SwissProt Entrez-Gene
Orthologous residues
GJA1 (human): S328‑p, GJA1 (mouse): S328‑p, GJA1 (rat): S328‑p, GJA1 (rabbit): S328‑p, GJA1 (pig): S328‑p, GJA1 (hamster): S328‑p, GJA1 (cow): S329‑p
Characterization
Methods used to characterize site in vivo mutation of modification site, phospho-antibody, western blotting
Relevant cell lines - cell types - tissues:  heart, MDCK (epithelial)
Cellular systems studied:  cell lines, tissue
Species studied:  dog, mouse

S330-p - GJA1 (mouse)
Modsite: AGstIsNsHAQPFDF SwissProt Entrez-Gene
Orthologous residues
GJA1 (human): S330‑p, GJA1 (mouse): S330‑p, GJA1 (rat): S330‑p, GJA1 (rabbit): S330‑p, GJA1 (pig): S330‑p, GJA1 (hamster): S330‑p, GJA1 (cow): S331‑p
Characterization
Methods used to characterize site in vivo mutation of modification site, phospho-antibody, western blotting
Relevant cell lines - cell types - tissues:  heart, MDCK (epithelial)
Cellular systems studied:  cell lines, tissue
Species studied:  dog, mouse
Downstream Regulation
Effect of modification (function):  molecular association, regulation
Effect of modification (process):  signaling pathway regulation
Modification regulates interactions with: 
Interacting molecule Interacting domains Effect Consequences (function) Consequences (process) Detection assays
ERK1 (mouse) Disrupts phosphorylation co-immunoprecipitation
Comments:  ERK phosphorylation reduced

T346-p - NDRG1 (mouse)
Modsite: GtRsRsHtsEGPRsR SwissProt Entrez-Gene
Orthologous residues
NDRG1 (human): T346‑p, NDRG1 iso2 (human): T280‑p, NDRG1 iso3 (human): T265‑p, NDRG1 (mouse): T346‑p, NDRG1 (rat): T346‑p, NDRG1 (cow): T346‑p
Characterization
Methods used to characterize site in vivo phospho-antibody, western blotting
Relevant cell lines - cell types - tissues:  heart
Cellular systems studied:  tissue
Species studied:  mouse