Curated Information
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Home > Curated Information Page > PubMed Id: 31075185
Liu W, et al. (2019) RhoGDI2 positively regulates the Rho GTPases activation in response to the β2 outside-in signaling in T cells adhesion and migration on ICAM-1. J Leukoc Biol 31075185
This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2015, 43:D512-20). To learn more about the scope of PhosphoSitePlus®, click here.
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Y24-p - RhoGDI beta (human)
Modsite: ELdskLNykPPPQks SwissProt Entrez-Gene
Orthologous residues
RhoGDI beta (human): Y24‑p, RhoGDI beta (mouse): Y23‑p, RhoGDI beta (rat): Y23‑p
Characterization
Methods used to characterize site in vivo mutation of modification site
Disease tissue studied:  leukemia, T cell leukemia
Relevant cell lines - cell types - tissues:  Jurkat (T lymphocyte)
Cellular systems studied:  cell lines
Species studied:  human
Downstream Regulation
Effect of modification (function):  intracellular localization, molecular association, regulation
Modification regulates interactions with: 
Interacting molecule Interacting domains Effect Consequences (function) Consequences (process) Detection assays
CDC42 (human) Disrupts pull-down assay
RAC1 (human) Disrupts pull-down assay

S31-p - RhoGDI beta (human)
Modsite: ykPPPQksLkELQEM SwissProt Entrez-Gene
Orthologous residues
RhoGDI beta (human): S31‑p, RhoGDI beta (mouse): S30‑p, RhoGDI beta (rat): S30‑p
Characterization
Methods used to characterize site in vivo mutation of modification site
Disease tissue studied:  leukemia, T cell leukemia
Relevant cell lines - cell types - tissues:  Jurkat (T lymphocyte)
Cellular systems studied:  cell lines
Species studied:  human
Downstream Regulation
Effect of modification (function):  molecular association, regulation
Modification regulates interactions with: 
Interacting molecule Interacting domains Effect Consequences (function) Consequences (process) Detection assays
CDC42 (human) Disrupts pull-down assay
RAC1 (human) Disrupts pull-down assay

Y153-p - RhoGDI beta (human)
Modsite: yGPRPEEyEFLtPVE SwissProt Entrez-Gene
Orthologous residues
RhoGDI beta (human): Y153‑p, RhoGDI beta (mouse): Y152‑p, RhoGDI beta (rat): Y152‑p
Characterization
Methods used to characterize site in vivo mutation of modification site
Disease tissue studied:  leukemia, T cell leukemia
Relevant cell lines - cell types - tissues:  Jurkat (T lymphocyte)
Cellular systems studied:  cell lines
Species studied:  human
Downstream Regulation
Effect of modification (function):  intracellular localization, molecular association, regulation
Modification regulates interactions with: 
Interacting molecule Interacting domains Effect Consequences (function) Consequences (process) Detection assays
RAC1 (human) Disrupts pull-down assay
CDC42 (human) Disrupts pull-down assay
VAV1 (human) Induces pull-down assay