Curated Information
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Home > Curated Information Page > PubMed Id: 20432439
Zhang Z, et al. (2010) Constitutive activation of the mitogen-activated protein kinase pathway impairs vitamin D signaling in human prostate epithelial cells. J Cell Physiol 224, 433-42 20432439
This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2015, 43:D512-20). To learn more about the scope of PhosphoSitePlus®, click here.
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S32-p - RXRA (human)
Modsite: RGsMAAPsLHPSLGP SwissProt Entrez-Gene
Orthologous residues
RXRA (human): S32‑p, RXRA (mouse): S33‑p, RXRA (rat): S33‑p
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
1,25_dihydroxyvitamin_D decrease
Downstream Regulation
Effect of modification (function):  molecular association, regulation
Effect of modification (process):  transcription, inhibited
Modification regulates interactions with: 
Interacting molecule Interacting domains Effect Consequences (function) Consequences (process) Detection assays
SRC-1 (human) Disrupts co-immunoprecipitation

T82-p - RXRA (human)
Modsite: HSMsVPTtPTLGFST SwissProt Entrez-Gene
Orthologous residues
RXRA (human): T82‑p, RXRA (mouse): T87‑p, RXRA (rat): T87‑p
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
1,25_dihydroxyvitamin_D decrease
Downstream Regulation
Effect of modification (function):  molecular association, regulation
Effect of modification (process):  transcription, inhibited
Modification regulates interactions with: 
Interacting molecule Interacting domains Effect Consequences (function) Consequences (process) Detection assays
SRC-1 (human) Disrupts co-immunoprecipitation

Y249-p - RXRA (human)
Modsite: VEPKTETyVEANMGL SwissProt Entrez-Gene
Orthologous residues
RXRA (human): Y249‑p, RXRA (mouse): Y254‑p, RXRA (rat): Y254‑p
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
1,25_dihydroxyvitamin_D decrease

S260-p - RXRA (human)
Modsite: NMGLNPssPNDPVtN SwissProt Entrez-Gene
Orthologous residues
RXRA (human): S260‑p, RXRA (mouse): S265‑p, RXRA (rat): S265‑p
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
1,25_dihydroxyvitamin_D decrease