Curated Information
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Home > Curated Information Page > PubMed Id: 20403076
Ceglia I, Kim Y, Nairn AC, Greengard P (2010) Signaling pathways controlling the phosphorylation state of WAVE1, a regulator of actin polymerization. J Neurochem 114, 182-90 20403076
This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2015, 43:D512-20). To learn more about the scope of PhosphoSitePlus®, click here.
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S310-p - WAVE1 (mouse)
Modsite: LIENRPQsPAAGRTP SwissProt Entrez-Gene
Orthologous residues
WAVE1 (human): S310‑p, WAVE1 (mouse): S310‑p, WAVE1 (rat): S310‑p
Upstream Regulation
Potential in vivo enzymes for site: 
Type Enzyme Evidence Notes
PHOSPHATASE PPP2CA (mouse) pharmacological inhibitor of upstream enzyme
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
quinpirole increase
okadaic_acid increase
colforsin decrease
okadaic_acid colforsin inhibit treatment-induced decrease
tautomycetin colforsin no effect upon treatment-induced decrease
ciclosporin colforsin no effect upon treatment-induced decrease
NMDA decrease
okadaic_acid NMDA inhibit treatment-induced decrease
ciclosporin no change compared to control
ciclosporin NMDA no effect upon treatment-induced decrease
Downstream Regulation
Effect of modification (function):  activity, inhibited

S397-p - WAVE1 (mouse)
Modsite: APPLVQPsPPVARAA SwissProt Entrez-Gene
Orthologous residues
WAVE1 (human): S397‑p, WAVE1 (mouse): S397‑p, WAVE1 (rat): S397‑p
Upstream Regulation
Potential in vivo enzymes for site: 
Type Enzyme Evidence Notes
PHOSPHATASE PPP2CB (mouse) pharmacological inhibitor of upstream enzyme
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
quinpirole increase
okadaic_acid no change compared to control
colforsin decrease
okadaic_acid colforsin inhibit treatment-induced decrease
tautomycetin colforsin no effect upon treatment-induced decrease
ciclosporin colforsin no effect upon treatment-induced decrease
NMDA decrease
okadaic_acid NMDA no effect upon treatment-induced decrease
ciclosporin no change compared to control slight increase
ciclosporin NMDA inhibit treatment-induced decrease
Downstream Regulation
Effect of modification (function):  activity, inhibited

S441-p - WAVE1 (mouse)
Modsite: PPGIRPSsPVAVAAL SwissProt Entrez-Gene
Orthologous residues
WAVE1 (human): S441‑p, WAVE1 (mouse): S441‑p, WAVE1 (rat): S441‑p
Upstream Regulation
Potential in vivo enzymes for site: 
Type Enzyme Evidence Notes
PHOSPHATASE PPP2CA (mouse) pharmacological inhibitor of upstream enzyme
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
okadaic_acid increase
colforsin decrease
okadaic_acid colforsin inhibit treatment-induced decrease
tautomycetin colforsin inhibit treatment-induced decrease small effect
ciclosporin colforsin inhibit treatment-induced decrease
NMDA decrease
okadaic_acid NMDA inhibit treatment-induced decrease
ciclosporin no change compared to control
ciclosporin NMDA no effect upon treatment-induced decrease
Downstream Regulation
Effect of modification (function):  activity, inhibited