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Home > Curated Information Page > PubMed Id: 20438120
Iwai LK, Benoist C, Mathis D, White FM (2010) Quantitative phosphoproteomic analysis of T cell receptor signaling in diabetes prone and resistant mice. J Proteome Res 9, 3135-45 20438120
This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2015, 43:D512-20). To learn more about the scope of PhosphoSitePlus®, click here.
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Y93-p - ACTA1 (mouse)
Modsite: kIWHHtFyNELRVAP SwissProt Entrez-Gene
Orthologous residues
ACTA1 (human): Y93‑p, ACTA1 (mouse): Y93‑p, ACTA1 (rat): Y93‑p, ACTA1 (rabbit): Y93‑p
Characterization
Methods used to characterize site in vivo mass spectrometry
Relevant cell lines - cell types - tissues:  T lymphocyte-lymph node
Cellular systems studied:  primary cells
Species studied:  mouse
Comments:  CD4+ T cells from diabetes-prone NOD mice, anti-CD3-stimulated, CD4+ T cells from diabetes-prone NOD mice, unstimulated, CD4+ T cells from diabetes-resistant B6.H2g7 mice, anti-CD3-stimulated, CD4+ T cells from diabetes-resistant B6.H2g7 mice, unstimulated

Y91-p - ACTB (mouse)
Modsite: KIWHHtFyNELRVAP SwissProt Entrez-Gene
Orthologous residues
ACTB (human): Y91‑p, ACTB (mouse): Y91‑p, ACTB (rat): Y91‑p, ACTB (cow): Y91‑p
Characterization
Methods used to characterize site in vivo mass spectrometry
Relevant cell lines - cell types - tissues:  T lymphocyte-lymph node
Cellular systems studied:  primary cells
Species studied:  mouse
Comments:  CD4+ T cells from diabetes-prone NOD mice, anti-CD3-stimulated, CD4+ T cells from diabetes-prone NOD mice, unstimulated, CD4+ T cells from diabetes-resistant B6.H2g7 mice, anti-CD3-stimulated, CD4+ T cells from diabetes-resistant B6.H2g7 mice, unstimulated

Y166-p - ACTB (mouse)
Modsite: VTHTVPIyEGyALPH SwissProt Entrez-Gene
Orthologous residues
ACTB (human): Y166‑p, ACTB (mouse): Y166‑p, ACTB (rat): Y166‑p, ACTB (cow): Y166‑p
Characterization
Methods used to characterize site in vivo mass spectrometry
Relevant cell lines - cell types - tissues:  T lymphocyte-lymph node
Cellular systems studied:  primary cells
Species studied:  mouse
Comments:  CD4+ T cells from diabetes-prone NOD mice, anti-CD3-stimulated, CD4+ T cells from diabetes-prone NOD mice, unstimulated, CD4+ T cells from diabetes-resistant B6.H2g7 mice, anti-CD3-stimulated, CD4+ T cells from diabetes-resistant B6.H2g7 mice, unstimulated

Y198-p - ACTB (mouse)
Modsite: kILTERGysFtttAE SwissProt Entrez-Gene
Orthologous residues
ACTB (human): Y198‑p, ACTB (mouse): Y198‑p, ACTB (rat): Y198‑p, ACTB (cow): Y198‑p
Characterization
Methods used to characterize site in vivo mass spectrometry
Relevant cell lines - cell types - tissues:  T lymphocyte-lymph node
Cellular systems studied:  primary cells
Species studied:  mouse
Comments:  CD4+ T cells from diabetes-prone NOD mice, anti-CD3-stimulated, CD4+ T cells from diabetes-prone NOD mice, unstimulated, CD4+ T cells from diabetes-resistant B6.H2g7 mice, anti-CD3-stimulated, CD4+ T cells from diabetes-resistant B6.H2g7 mice, unstimulated

Y218-p - ACTB (mouse)
Modsite: DIkEkLCyVALDFEQ SwissProt Entrez-Gene
Orthologous residues
ACTB (human): Y218‑p, ACTB (mouse): Y218‑p, ACTB (rat): Y218‑p, ACTB (cow): Y218‑p
Characterization
Methods used to characterize site in vivo mass spectrometry
Relevant cell lines - cell types - tissues:  T lymphocyte-lymph node
Cellular systems studied:  primary cells
Species studied:  mouse
Comments:  CD4+ T cells from diabetes-prone NOD mice, anti-CD3-stimulated, CD4+ T cells from diabetes-prone NOD mice, unstimulated, CD4+ T cells from diabetes-resistant B6.H2g7 mice, anti-CD3-stimulated, CD4+ T cells from diabetes-resistant B6.H2g7 mice, unstimulated

Y294-p - ACTB (mouse)
Modsite: VDIRkDLyANtVLsG SwissProt Entrez-Gene
Orthologous residues
ACTB (human): Y294‑p, ACTB (mouse): Y294‑p, ACTB (rat): Y294‑p, ACTB (cow): Y294‑p
Characterization
Methods used to characterize site in vivo mass spectrometry
Relevant cell lines - cell types - tissues:  T lymphocyte-lymph node
Cellular systems studied:  primary cells
Species studied:  mouse
Comments:  CD4+ T cells from diabetes-prone NOD mice, anti-CD3-stimulated, CD4+ T cells from diabetes-prone NOD mice, unstimulated, CD4+ T cells from diabetes-resistant B6.H2g7 mice, anti-CD3-stimulated, CD4+ T cells from diabetes-resistant B6.H2g7 mice, unstimulated

Y167-p - ACTBL2 (mouse)
Modsite: VTHTVPIyEGyALPH SwissProt Entrez-Gene
Orthologous residues
ACTBL2 (human): Y167‑p, ACTBL2 (mouse): Y167‑p, ACTBL2 (rat): Y167‑p
Characterization
Methods used to characterize site in vivo mass spectrometry
Relevant cell lines - cell types - tissues:  T lymphocyte-lymph node
Cellular systems studied:  primary cells
Species studied:  mouse
Comments:  CD4+ T cells from diabetes-prone NOD mice, anti-CD3-stimulated, CD4+ T cells from diabetes-prone NOD mice, unstimulated, CD4+ T cells from diabetes-resistant B6.H2g7 mice, anti-CD3-stimulated, CD4+ T cells from diabetes-resistant B6.H2g7 mice, unstimulated

Y93-p - ACTC1 (mouse)
Modsite: kIWHHtFyNELRVAP SwissProt Entrez-Gene
Orthologous residues
ACTC1 (human): Y93‑p, ACTC1 (mouse): Y93‑p, ACTC1 (rat): Y93‑p
Characterization
Methods used to characterize site in vivo mass spectrometry
Relevant cell lines - cell types - tissues:  T lymphocyte-lymph node
Cellular systems studied:  primary cells
Species studied:  mouse
Comments:  CD4+ T cells from diabetes-prone NOD mice, anti-CD3-stimulated, CD4+ T cells from diabetes-prone NOD mice, unstimulated, CD4+ T cells from diabetes-resistant B6.H2g7 mice, anti-CD3-stimulated, CD4+ T cells from diabetes-resistant B6.H2g7 mice, unstimulated

Y91-p - ACTG1 (mouse)
Modsite: KIWHHtFyNELRVAP SwissProt Entrez-Gene
Orthologous residues
ACTG1 (human): Y91‑p, ACTG1 (mouse): Y91‑p, ACTG1 (rat): Y91‑p
Characterization
Methods used to characterize site in vivo mass spectrometry
Relevant cell lines - cell types - tissues:  T lymphocyte-lymph node
Cellular systems studied:  primary cells
Species studied:  mouse
Comments:  CD4+ T cells from diabetes-prone NOD mice, anti-CD3-stimulated, CD4+ T cells from diabetes-prone NOD mice, unstimulated, CD4+ T cells from diabetes-resistant B6.H2g7 mice, anti-CD3-stimulated, CD4+ T cells from diabetes-resistant B6.H2g7 mice, unstimulated

Y166-p - ACTG1 (mouse)
Modsite: VTHTVPIyEGyALPH SwissProt Entrez-Gene
Orthologous residues
ACTG1 (human): Y166‑p, ACTG1 (mouse): Y166‑p, ACTG1 (rat): Y166‑p
Characterization
Methods used to characterize site in vivo mass spectrometry
Relevant cell lines - cell types - tissues:  T lymphocyte-lymph node
Cellular systems studied:  primary cells
Species studied:  mouse
Comments:  CD4+ T cells from diabetes-prone NOD mice, anti-CD3-stimulated, CD4+ T cells from diabetes-prone NOD mice, unstimulated, CD4+ T cells from diabetes-resistant B6.H2g7 mice, anti-CD3-stimulated, CD4+ T cells from diabetes-resistant B6.H2g7 mice, unstimulated

Y198-p - ACTG1 (mouse)
Modsite: kILTERGysFtttAE SwissProt Entrez-Gene
Orthologous residues
ACTG1 (human): Y198‑p, ACTG1 (mouse): Y198‑p, ACTG1 (rat): Y198‑p
Characterization
Methods used to characterize site in vivo mass spectrometry
Relevant cell lines - cell types - tissues:  T lymphocyte-lymph node
Cellular systems studied:  primary cells
Species studied:  mouse
Comments:  CD4+ T cells from diabetes-prone NOD mice, anti-CD3-stimulated, CD4+ T cells from diabetes-prone NOD mice, unstimulated, CD4+ T cells from diabetes-resistant B6.H2g7 mice, anti-CD3-stimulated, CD4+ T cells from diabetes-resistant B6.H2g7 mice, unstimulated

Y218-p - ACTG1 (mouse)
Modsite: DIkEkLCyVALDFEQ SwissProt Entrez-Gene
Orthologous residues
ACTG1 (human): Y218‑p, ACTG1 (mouse): Y218‑p, ACTG1 (rat): Y218‑p
Characterization
Methods used to characterize site in vivo mass spectrometry
Relevant cell lines - cell types - tissues:  T lymphocyte-lymph node
Cellular systems studied:  primary cells
Species studied:  mouse
Comments:  CD4+ T cells from diabetes-prone NOD mice, anti-CD3-stimulated, CD4+ T cells from diabetes-prone NOD mice, unstimulated, CD4+ T cells from diabetes-resistant B6.H2g7 mice, anti-CD3-stimulated, CD4+ T cells from diabetes-resistant B6.H2g7 mice, unstimulated

Y294-p - ACTG1 (mouse)
Modsite: VDIRkDLyANtVLsG SwissProt Entrez-Gene
Orthologous residues
ACTG1 (human): Y294‑p, ACTG1 (mouse): Y294‑p, ACTG1 (rat): Y294‑p
Characterization
Methods used to characterize site in vivo mass spectrometry
Relevant cell lines - cell types - tissues:  T lymphocyte-lymph node
Cellular systems studied:  primary cells
Species studied:  mouse
Comments:  CD4+ T cells from diabetes-prone NOD mice, anti-CD3-stimulated, CD4+ T cells from diabetes-prone NOD mice, unstimulated, CD4+ T cells from diabetes-resistant B6.H2g7 mice, anti-CD3-stimulated, CD4+ T cells from diabetes-resistant B6.H2g7 mice, unstimulated

Y30-p - ANXA6 (mouse)
Modsite: NQDAEALyTAMkGFG SwissProt Entrez-Gene
Orthologous residues
ANXA6 (human): Y30‑p, ANXA6 iso2 (human): Y30‑p, ANXA6 (mouse): Y30‑p, ANXA6 iso2 (mouse): Y30‑p, ANXA6 (rat): Y30‑p
Characterization
Methods used to characterize site in vivo mass spectrometry
Relevant cell lines - cell types - tissues:  T lymphocyte-lymph node
Cellular systems studied:  primary cells
Species studied:  mouse
Comments:  CD4+ T cells from diabetes-prone NOD mice, anti-CD3-stimulated, CD4+ T cells from diabetes-prone NOD mice, unstimulated, CD4+ T cells from diabetes-resistant B6.H2g7 mice, anti-CD3-stimulated, CD4+ T cells from diabetes-resistant B6.H2g7 mice, unstimulated

Y28-p - ARHGAP27 iso2 (mouse)
Modsite: DDPPEPVyANVERQP SwissProt Entrez-Gene
Orthologous residues
ARHGAP27 (human): Y228‑p, ARHGAP27 iso5 (human): Y28‑p, ARHGAP27 (mouse): Y227‑p, ARHGAP27 iso2 (mouse): Y28‑p, ARHGAP27 iso3 (mouse): , ARHGAP27 (rat): Y227‑p
Characterization
Methods used to characterize site in vivo mass spectrometry
Relevant cell lines - cell types - tissues:  T lymphocyte-lymph node
Cellular systems studied:  primary cells
Species studied:  mouse
Comments:  CD4+ T cells from diabetes-prone NOD mice, anti-CD3-stimulated, CD4+ T cells from diabetes-prone NOD mice, unstimulated, CD4+ T cells from diabetes-resistant B6.H2g7 mice, anti-CD3-stimulated, CD4+ T cells from diabetes-resistant B6.H2g7 mice, unstimulated

Y381-p - BDP1 (mouse)
Modsite: TSTDTPIysQVAPRA SwissProt Entrez-Gene
Orthologous residues
BDP1 (human): Y389‑p, BDP1 iso2 (human): Y282‑p, BDP1 (mouse): Y381‑p, BDP1 (rat): Y381‑p
Characterization
Methods used to characterize site in vivo mass spectrometry
Relevant cell lines - cell types - tissues:  T lymphocyte-lymph node
Cellular systems studied:  primary cells
Species studied:  mouse
Comments:  CD4+ T cells from diabetes-prone NOD mice, anti-CD3-stimulated, CD4+ T cells from diabetes-prone NOD mice, unstimulated, CD4+ T cells from diabetes-resistant B6.H2g7 mice, anti-CD3-stimulated, CD4+ T cells from diabetes-resistant B6.H2g7 mice, unstimulated

Y100-p - Calmodulin (mouse)
Modsite: FDkDGnGyIsAAELR SwissProt Entrez-Gene
Orthologous residues
Calmodulin (human): Y100‑p, Calmodulin (mouse): Y100‑p, Calmodulin (rat): Y100‑p, Calmodulin (chicken): Y100‑p, Calmodulin (sheep): Y100‑p, Calmodulin (cow): Y100‑p
Characterization
Methods used to characterize site in vivo mass spectrometry
Relevant cell lines - cell types - tissues:  T lymphocyte-lymph node
Cellular systems studied:  primary cells
Species studied:  mouse
Comments:  CD4+ T cells from diabetes-prone NOD mice, anti-CD3-stimulated, CD4+ T cells from diabetes-prone NOD mice, unstimulated, CD4+ T cells from diabetes-resistant B6.H2g7 mice, anti-CD3-stimulated, CD4+ T cells from diabetes-resistant B6.H2g7 mice, unstimulated
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
anti-CD3 increase

Y625-p - CD229 (mouse)
Modsite: KEDsNtIyCSVQKPK SwissProt Entrez-Gene
Orthologous residues
CD229 (human): Y626‑p, CD229 iso4 (human): Y626‑p, CD229 (mouse): Y625‑p, CD229 (rat): Y626‑p
Characterization
Methods used to characterize site in vivo mass spectrometry
Relevant cell lines - cell types - tissues:  T lymphocyte-lymph node
Cellular systems studied:  primary cells
Species studied:  mouse
Comments:  CD4+ T cells from diabetes-prone NOD mice, anti-CD3-stimulated, CD4+ T cells from diabetes-prone NOD mice, unstimulated, CD4+ T cells from diabetes-resistant B6.H2g7 mice, anti-CD3-stimulated, CD4+ T cells from diabetes-resistant B6.H2g7 mice, unstimulated
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
anti-CD3 decrease

Y149-p - CD3D (mouse)
Modsite: LLKNEQLyQPLRDRE SwissProt Entrez-Gene
Orthologous residues
CD3D (human): Y149‑p, CD3D (mouse): Y149‑p
Characterization
Methods used to characterize site in vivo mass spectrometry
Relevant cell lines - cell types - tissues:  T lymphocyte-lymph node
Cellular systems studied:  primary cells
Species studied:  mouse
Comments:  CD4+ T cells from diabetes-prone NOD mice, anti-CD3-stimulated, CD4+ T cells from diabetes-prone NOD mice, unstimulated, CD4+ T cells from diabetes-resistant B6.H2g7 mice, anti-CD3-stimulated, CD4+ T cells from diabetes-resistant B6.H2g7 mice, unstimulated

Y170-p - CD3E (mouse)
Modsite: PPVPNPDyEPIRKGQ SwissProt Entrez-Gene
Orthologous residues
CD3E (human): Y188‑p, CD3E (mouse): Y170‑p, CD3E (rat): Y169‑p
Characterization
Methods used to characterize site in vivo mass spectrometry
Relevant cell lines - cell types - tissues:  T lymphocyte-lymph node
Cellular systems studied:  primary cells
Species studied:  mouse
Comments:  CD4+ T cells from diabetes-prone NOD mice, anti-CD3-stimulated, CD4+ T cells from diabetes-prone NOD mice, unstimulated, CD4+ T cells from diabetes-resistant B6.H2g7 mice, anti-CD3-stimulated, CD4+ T cells from diabetes-resistant B6.H2g7 mice, unstimulated
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
anti-CD3 increase

Y181-p - CD3E (mouse)
Modsite: RKGQRDLySGLNQRA SwissProt Entrez-Gene
Orthologous residues
CD3E (human): Y199‑p, CD3E (mouse): Y181‑p, CD3E (rat): Y180‑p
Characterization
Methods used to characterize site in vivo mass spectrometry
Relevant cell lines - cell types - tissues:  T lymphocyte-lymph node
Cellular systems studied:  primary cells
Species studied:  mouse
Comments:  CD4+ T cells from diabetes-prone NOD mice, anti-CD3-stimulated, CD4+ T cells from diabetes-prone NOD mice, unstimulated, CD4+ T cells from diabetes-resistant B6.H2g7 mice, anti-CD3-stimulated, CD4+ T cells from diabetes-resistant B6.H2g7 mice, unstimulated
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
anti-CD3 increase

Y160-p - CD3G (mouse)
Modsite: LLQNEQLyQPLKDRE SwissProt Entrez-Gene
Orthologous residues
CD3G (human): Y160‑p, CD3G (mouse): Y160‑p
Characterization
Methods used to characterize site in vivo mass spectrometry
Relevant cell lines - cell types - tissues:  T lymphocyte-lymph node
Cellular systems studied:  primary cells
Species studied:  mouse
Comments:  CD4+ T cells from diabetes-prone NOD mice, anti-CD3-stimulated, CD4+ T cells from diabetes-prone NOD mice, unstimulated, CD4+ T cells from diabetes-resistant B6.H2g7 mice, anti-CD3-stimulated, CD4+ T cells from diabetes-resistant B6.H2g7 mice, unstimulated

Y171-p - CD3G (mouse)
Modsite: KDREYDQySHLQGNQ SwissProt Entrez-Gene
Orthologous residues
CD3G (human): Y171‑p, CD3G (mouse): Y171‑p
Characterization
Methods used to characterize site in vivo mass spectrometry
Relevant cell lines - cell types - tissues:  T lymphocyte-lymph node
Cellular systems studied:  primary cells
Species studied:  mouse
Comments:  CD4+ T cells from diabetes-prone NOD mice, anti-CD3-stimulated, CD4+ T cells from diabetes-prone NOD mice, unstimulated, CD4+ T cells from diabetes-resistant B6.H2g7 mice, anti-CD3-stimulated, CD4+ T cells from diabetes-resistant B6.H2g7 mice, unstimulated

Y72-p - CD3Z (mouse)
Modsite: LQDPNQLyNELNLGR SwissProt Entrez-Gene
Orthologous residues
CD3Z (human): Y72‑p, CD3Z iso3 (human): Y72‑p, CD3Z (mouse): Y72‑p, CD3Z iso2 (mouse): Y72‑p, CD3Z (rat): Y72‑p
Characterization
Methods used to characterize site in vivo mass spectrometry
Relevant cell lines - cell types - tissues:  T lymphocyte-lymph node
Cellular systems studied:  primary cells
Species studied:  mouse
Comments:  CD4+ T cells from diabetes-prone NOD mice, anti-CD3-stimulated, CD4+ T cells from diabetes-prone NOD mice, unstimulated, CD4+ T cells from diabetes-resistant B6.H2g7 mice, anti-CD3-stimulated, CD4+ T cells from diabetes-resistant B6.H2g7 mice, unstimulated
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
anti-CD3 increase

Y83-p - CD3Z (mouse)
Modsite: NLGRREEyDVLEKKR SwissProt Entrez-Gene
Orthologous residues
CD3Z (human): Y83‑p, CD3Z iso3 (human): Y83‑p, CD3Z (mouse): Y83‑p, CD3Z iso2 (mouse): Y83‑p, CD3Z (rat): Y83‑p
Characterization
Methods used to characterize site in vivo mass spectrometry
Relevant cell lines - cell types - tissues:  T lymphocyte-lymph node
Cellular systems studied:  primary cells
Species studied:  mouse
Comments:  CD4+ T cells from diabetes-prone NOD mice, anti-CD3-stimulated, CD4+ T cells from diabetes-prone NOD mice, unstimulated, CD4+ T cells from diabetes-resistant B6.H2g7 mice, anti-CD3-stimulated, CD4+ T cells from diabetes-resistant B6.H2g7 mice, unstimulated

Y111-p - CD3Z (mouse)
Modsite: RNPQEGVyNALQKDK SwissProt Entrez-Gene
Orthologous residues
CD3Z (human): Y111‑p, CD3Z iso3 (human): Y110‑p, CD3Z (mouse): Y111‑p, CD3Z iso2 (mouse): Y111‑p, CD3Z (rat): Y111‑p
Characterization
Methods used to characterize site in vivo mass spectrometry
Relevant cell lines - cell types - tissues:  T lymphocyte-lymph node
Cellular systems studied:  primary cells
Species studied:  mouse
Comments:  CD4+ T cells from diabetes-prone NOD mice, anti-CD3-stimulated, CD4+ T cells from diabetes-prone NOD mice, unstimulated, CD4+ T cells from diabetes-resistant B6.H2g7 mice, anti-CD3-stimulated, CD4+ T cells from diabetes-resistant B6.H2g7 mice, unstimulated

Y123-p - CD3Z (mouse)
Modsite: KDKMAEAysEIGTKG SwissProt Entrez-Gene
Orthologous residues
CD3Z (human): Y123‑p, CD3Z iso3 (human): Y122‑p, CD3Z (mouse): Y123‑p, CD3Z iso2 (mouse): Y123‑p, CD3Z (rat): Y123‑p
Characterization
Methods used to characterize site in vivo mass spectrometry
Relevant cell lines - cell types - tissues:  T lymphocyte-lymph node
Cellular systems studied:  primary cells
Species studied:  mouse
Comments:  CD4+ T cells from diabetes-prone NOD mice, anti-CD3-stimulated, CD4+ T cells from diabetes-prone NOD mice, unstimulated, CD4+ T cells from diabetes-resistant B6.H2g7 mice, anti-CD3-stimulated, CD4+ T cells from diabetes-resistant B6.H2g7 mice, unstimulated

Y142-p - CD3Z (mouse)
Modsite: GKGHDGLyQGLsTAT SwissProt Entrez-Gene
Orthologous residues
CD3Z (human): Y142‑p, CD3Z iso3 (human): Y141‑p, CD3Z (mouse): Y142‑p, CD3Z iso2 (mouse): Y142‑p, CD3Z (rat): Y142‑p
Characterization
Methods used to characterize site in vivo mass spectrometry
Relevant cell lines - cell types - tissues:  T lymphocyte-lymph node
Cellular systems studied:  primary cells
Species studied:  mouse
Comments:  CD4+ T cells from diabetes-prone NOD mice, anti-CD3-stimulated, CD4+ T cells from diabetes-prone NOD mice, unstimulated, CD4+ T cells from diabetes-resistant B6.H2g7 mice, anti-CD3-stimulated, CD4+ T cells from diabetes-resistant B6.H2g7 mice, unstimulated

Y452-p - CD5 (mouse)
Modsite: ASHVDNEySQPPRNS SwissProt Entrez-Gene
Orthologous residues
CD5 (human): Y453‑p, CD5 (mouse): Y452‑p, CD5 (rat): Y449‑p
Characterization
Methods used to characterize site in vivo mass spectrometry
Relevant cell lines - cell types - tissues:  T lymphocyte-lymph node
Cellular systems studied:  primary cells
Species studied:  mouse
Comments:  CD4+ T cells from diabetes-prone NOD mice, anti-CD3-stimulated, CD4+ T cells from diabetes-prone NOD mice, unstimulated, CD4+ T cells from diabetes-resistant B6.H2g7 mice, anti-CD3-stimulated, CD4+ T cells from diabetes-resistant B6.H2g7 mice, unstimulated
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
anti-CD3 increase

T14-p - CDK1 (mouse)
Modsite: IEKIGEGtyGVVyKG SwissProt Entrez-Gene
Orthologous residues
CDK1 (human): T14‑p, CDK1 iso2 (human): T14‑p, CDK1 (mouse): T14‑p, CDK1 (rat): T14‑p, CDK1 (chicken): T14‑p, CDK1 (fruit fly): T14‑p
Characterization
Methods used to characterize site in vivo mass spectrometry
Relevant cell lines - cell types - tissues:  T lymphocyte-lymph node
Cellular systems studied:  primary cells
Species studied:  mouse
Comments:  CD4+ T cells from diabetes-prone NOD mice, anti-CD3-stimulated, CD4+ T cells from diabetes-prone NOD mice, unstimulated, CD4+ T cells from diabetes-resistant B6.H2g7 mice, anti-CD3-stimulated, CD4+ T cells from diabetes-resistant B6.H2g7 mice, unstimulated

Y15-p - CDK1 (mouse)
Modsite: EKIGEGtyGVVyKGR SwissProt Entrez-Gene
Orthologous residues
CDK1 (human): Y15‑p, CDK1 iso2 (human): Y15‑p, CDK1 (mouse): Y15‑p, CDK1 (rat): Y15‑p, CDK1 (chicken): Y15‑p, CDK1 (fruit fly): Y15‑p
Characterization
Methods used to characterize site in vivo mass spectrometry
Relevant cell lines - cell types - tissues:  T lymphocyte-lymph node
Cellular systems studied:  primary cells
Species studied:  mouse
Comments:  CD4+ T cells from diabetes-prone NOD mice, anti-CD3-stimulated, CD4+ T cells from diabetes-prone NOD mice, unstimulated, CD4+ T cells from diabetes-resistant B6.H2g7 mice, anti-CD3-stimulated, CD4+ T cells from diabetes-resistant B6.H2g7 mice, unstimulated

T14-p - CDK2 (mouse)
Modsite: VEKIGEGtyGVVyKA SwissProt Entrez-Gene
Orthologous residues
CDK2 (human): T14‑p, CDK2 iso2 (human): T14‑p, CDK2 (mouse): T14‑p, CDK2 (rat): T14‑p
Characterization
Methods used to characterize site in vivo mass spectrometry
Relevant cell lines - cell types - tissues:  T lymphocyte-lymph node
Cellular systems studied:  primary cells
Species studied:  mouse
Comments:  CD4+ T cells from diabetes-prone NOD mice, anti-CD3-stimulated, CD4+ T cells from diabetes-prone NOD mice, unstimulated, CD4+ T cells from diabetes-resistant B6.H2g7 mice, anti-CD3-stimulated, CD4+ T cells from diabetes-resistant B6.H2g7 mice, unstimulated

Y15-p - CDK2 (mouse)
Modsite: EKIGEGtyGVVyKAK SwissProt Entrez-Gene
Orthologous residues
CDK2 (human): Y15‑p, CDK2 iso2 (human): Y15‑p, CDK2 (mouse): Y15‑p, CDK2 (rat): Y15‑p
Characterization
Methods used to characterize site in vivo mass spectrometry
Relevant cell lines - cell types - tissues:  T lymphocyte-lymph node
Cellular systems studied:  primary cells
Species studied:  mouse
Comments:  CD4+ T cells from diabetes-prone NOD mice, anti-CD3-stimulated, CD4+ T cells from diabetes-prone NOD mice, unstimulated, CD4+ T cells from diabetes-resistant B6.H2g7 mice, anti-CD3-stimulated, CD4+ T cells from diabetes-resistant B6.H2g7 mice, unstimulated

T14-p - CDK3 (mouse)
Modsite: VEKIGEGtyGVVyKA SwissProt Entrez-Gene
Orthologous residues
CDK3 (human): T14‑p, CDK3 (mouse): T14‑p, CDK3 (cow): T14‑p
Characterization
Methods used to characterize site in vivo mass spectrometry
Relevant cell lines - cell types - tissues:  T lymphocyte-lymph node
Cellular systems studied:  primary cells
Species studied:  mouse
Comments:  CD4+ T cells from diabetes-prone NOD mice, anti-CD3-stimulated, CD4+ T cells from diabetes-prone NOD mice, unstimulated, CD4+ T cells from diabetes-resistant B6.H2g7 mice, anti-CD3-stimulated, CD4+ T cells from diabetes-resistant B6.H2g7 mice, unstimulated

Y15-p - CDK3 (mouse)
Modsite: EKIGEGtyGVVyKAR SwissProt Entrez-Gene
Orthologous residues
CDK3 (human): Y15‑p, CDK3 (mouse): Y15‑p, CDK3 (cow): Y15‑p
Characterization
Methods used to characterize site in vivo mass spectrometry
Relevant cell lines - cell types - tissues:  T lymphocyte-lymph node
Cellular systems studied:  primary cells
Species studied:  mouse
Comments:  CD4+ T cells from diabetes-prone NOD mice, anti-CD3-stimulated, CD4+ T cells from diabetes-prone NOD mice, unstimulated, CD4+ T cells from diabetes-resistant B6.H2g7 mice, anti-CD3-stimulated, CD4+ T cells from diabetes-resistant B6.H2g7 mice, unstimulated

Y12-p - CRIP1 (mouse)
Modsite: PKCDkEVyFAERVTS SwissProt Entrez-Gene
Orthologous residues
CRIP1 (human): Y12‑p, CRIP1 (mouse): Y12‑p, CRIP1 (rat): Y12‑p
Characterization
Methods used to characterize site in vivo mass spectrometry
Relevant cell lines - cell types - tissues:  T lymphocyte-lymph node
Cellular systems studied:  primary cells
Species studied:  mouse
Comments:  CD4+ T cells from diabetes-prone NOD mice, anti-CD3-stimulated, CD4+ T cells from diabetes-prone NOD mice, unstimulated, CD4+ T cells from diabetes-resistant B6.H2g7 mice, anti-CD3-stimulated, CD4+ T cells from diabetes-resistant B6.H2g7 mice, unstimulated

Y212-p - DOCK2 (mouse)
Modsite: DQPDyGVySRISSSP SwissProt Entrez-Gene
Orthologous residues
DOCK2 (human): Y212‑p, DOCK2 (mouse): Y212‑p, DOCK2 (rat): Y212‑p
Characterization
Methods used to characterize site in vivo mass spectrometry
Relevant cell lines - cell types - tissues:  T lymphocyte-lymph node
Cellular systems studied:  primary cells
Species studied:  mouse
Comments:  CD4+ T cells from diabetes-prone NOD mice, anti-CD3-stimulated, CD4+ T cells from diabetes-prone NOD mice, unstimulated, CD4+ T cells from diabetes-resistant B6.H2g7 mice, anti-CD3-stimulated, CD4+ T cells from diabetes-resistant B6.H2g7 mice, unstimulated

Y321-p - DYRK1A (mouse)
Modsite: LGQRIyQyIQsRFYR SwissProt Entrez-Gene
Orthologous residues
DYRK1A (human): Y321‑p, DYRK1A iso2 (human): Y312‑p, DYRK1A iso4 (human): Y321‑p, DYRK1A (mouse): Y321‑p, DYRK1A (rat): Y321‑p, DYRK1A (rabbit):
Characterization
Methods used to characterize site in vivo mass spectrometry
Relevant cell lines - cell types - tissues:  T lymphocyte-lymph node
Cellular systems studied:  primary cells
Species studied:  mouse
Comments:  CD4+ T cells from diabetes-prone NOD mice, anti-CD3-stimulated, CD4+ T cells from diabetes-prone NOD mice, unstimulated, CD4+ T cells from diabetes-resistant B6.H2g7 mice, anti-CD3-stimulated, CD4+ T cells from diabetes-resistant B6.H2g7 mice, unstimulated

Y273-p - DYRK1B (mouse)
Modsite: LGQRIyQyIQsRFYR SwissProt Entrez-Gene
Orthologous residues
DYRK1B (human): Y273‑p, DYRK1B iso2 (human): Y273‑p, DYRK1B (mouse): Y273‑p, DYRK1B (rat): Y273‑p
Characterization
Methods used to characterize site in vivo mass spectrometry
Relevant cell lines - cell types - tissues:  T lymphocyte-lymph node
Cellular systems studied:  primary cells
Species studied:  mouse
Comments:  CD4+ T cells from diabetes-prone NOD mice, anti-CD3-stimulated, CD4+ T cells from diabetes-prone NOD mice, unstimulated, CD4+ T cells from diabetes-resistant B6.H2g7 mice, anti-CD3-stimulated, CD4+ T cells from diabetes-resistant B6.H2g7 mice, unstimulated

Y59-p - DYRK1C (mouse)
Modsite: LGQRIyQyIQsRFYR SwissProt Entrez-Gene
Orthologous residues
DYRK1C (mouse): Y59‑p
Characterization
Methods used to characterize site in vivo mass spectrometry
Relevant cell lines - cell types - tissues:  T lymphocyte-lymph node
Cellular systems studied:  primary cells
Species studied:  mouse
Comments:  CD4+ T cells from diabetes-prone NOD mice, anti-CD3-stimulated, CD4+ T cells from diabetes-prone NOD mice, unstimulated, CD4+ T cells from diabetes-resistant B6.H2g7 mice, anti-CD3-stimulated, CD4+ T cells from diabetes-resistant B6.H2g7 mice, unstimulated

Y25-p - ENO1 (mouse)
Modsite: PTVEVDLytAkGLFR SwissProt Entrez-Gene
Orthologous residues
ENO1 (human): F25‑p, ENO1 (mouse): Y25‑p, ENO1 (rat): Y25‑p, ENO1 (chicken): Y25‑p
Characterization
Methods used to characterize site in vivo mass spectrometry
Relevant cell lines - cell types - tissues:  T lymphocyte-lymph node
Cellular systems studied:  primary cells
Species studied:  mouse
Comments:  CD4+ T cells from diabetes-prone NOD mice, anti-CD3-stimulated, CD4+ T cells from diabetes-prone NOD mice, unstimulated, CD4+ T cells from diabetes-resistant B6.H2g7 mice, anti-CD3-stimulated, CD4+ T cells from diabetes-resistant B6.H2g7 mice, unstimulated

Y44-p - ENO1 (mouse)
Modsite: sGAstGIyEALELRD SwissProt Entrez-Gene
Orthologous residues
ENO1 (human): Y44‑p, ENO1 (mouse): Y44‑p, ENO1 (rat): Y44‑p, ENO1 (chicken): Y44‑p
Characterization
Methods used to characterize site in vivo mass spectrometry
Relevant cell lines - cell types - tissues:  T lymphocyte-lymph node
Cellular systems studied:  primary cells
Species studied:  mouse
Comments:  CD4+ T cells from diabetes-prone NOD mice, anti-CD3-stimulated, CD4+ T cells from diabetes-prone NOD mice, unstimulated, CD4+ T cells from diabetes-resistant B6.H2g7 mice, anti-CD3-stimulated, CD4+ T cells from diabetes-resistant B6.H2g7 mice, unstimulated

Y25-p - ENO2 (mouse)
Modsite: PTVEVDLytAkGLFR SwissProt Entrez-Gene
Orthologous residues
ENO2 (human): Y25‑p, ENO2 (mouse): Y25‑p, ENO2 (rat): H25‑p
Characterization
Methods used to characterize site in vivo mass spectrometry
Relevant cell lines - cell types - tissues:  T lymphocyte-lymph node
Cellular systems studied:  primary cells
Species studied:  mouse
Comments:  CD4+ T cells from diabetes-prone NOD mice, anti-CD3-stimulated, CD4+ T cells from diabetes-prone NOD mice, unstimulated, CD4+ T cells from diabetes-resistant B6.H2g7 mice, anti-CD3-stimulated, CD4+ T cells from diabetes-resistant B6.H2g7 mice, unstimulated

Y44-p - ENO2 (mouse)
Modsite: sGAstGIyEALELRD SwissProt Entrez-Gene
Orthologous residues
ENO2 (human): Y44‑p, ENO2 (mouse): Y44‑p, ENO2 (rat): Y44‑p
Characterization
Methods used to characterize site in vivo mass spectrometry
Relevant cell lines - cell types - tissues:  T lymphocyte-lymph node
Cellular systems studied:  primary cells
Species studied:  mouse
Comments:  CD4+ T cells from diabetes-prone NOD mice, anti-CD3-stimulated, CD4+ T cells from diabetes-prone NOD mice, unstimulated, CD4+ T cells from diabetes-resistant B6.H2g7 mice, anti-CD3-stimulated, CD4+ T cells from diabetes-resistant B6.H2g7 mice, unstimulated

Y44-p - ENO3 (mouse)
Modsite: sGAstGIyEALELRD SwissProt Entrez-Gene
Orthologous residues
ENO3 (human): Y44‑p, ENO3 iso100 (human): Y44‑p, ENO3 (mouse): Y44‑p, ENO3 (rat): Y44‑p
Characterization
Methods used to characterize site in vivo mass spectrometry
Relevant cell lines - cell types - tissues:  T lymphocyte-lymph node
Cellular systems studied:  primary cells
Species studied:  mouse
Comments:  CD4+ T cells from diabetes-prone NOD mice, anti-CD3-stimulated, CD4+ T cells from diabetes-prone NOD mice, unstimulated, CD4+ T cells from diabetes-resistant B6.H2g7 mice, anti-CD3-stimulated, CD4+ T cells from diabetes-resistant B6.H2g7 mice, unstimulated

Y205-p - ERK1 (mouse)
Modsite: HtGFLtEyVAtRWyR SwissProt Entrez-Gene
Orthologous residues
ERK1 (human): Y204‑p, ERK1 iso2 (human): Y204‑p, ERK1 iso3 (human): Y204‑p, ERK1 (mouse): Y205‑p, ERK1 (rat): Y205‑p, ERK1 (hamster): Y194‑p
Characterization
Methods used to characterize site in vivo mass spectrometry
Relevant cell lines - cell types - tissues:  T lymphocyte-lymph node
Cellular systems studied:  primary cells
Species studied:  mouse
Comments:  CD4+ T cells from diabetes-prone NOD mice, anti-CD3-stimulated, CD4+ T cells from diabetes-prone NOD mice, unstimulated, CD4+ T cells from diabetes-resistant B6.H2g7 mice, anti-CD3-stimulated, CD4+ T cells from diabetes-resistant B6.H2g7 mice, unstimulated

T183-p - ERK2 (mouse)
Modsite: HDHtGFLtEyVAtRW SwissProt Entrez-Gene
Orthologous residues
ERK2 (human): T185‑p, ERK2 (mouse): T183‑p, ERK2 (rat): T183‑p, ERK2 (chicken): T193‑p, ERK2 (cow): T185‑p
Characterization
Methods used to characterize site in vivo mass spectrometry
Relevant cell lines - cell types - tissues:  T lymphocyte-lymph node
Cellular systems studied:  primary cells
Species studied:  mouse
Comments:  CD4+ T cells from diabetes-prone NOD mice, anti-CD3-stimulated, CD4+ T cells from diabetes-prone NOD mice, unstimulated, CD4+ T cells from diabetes-resistant B6.H2g7 mice, anti-CD3-stimulated, CD4+ T cells from diabetes-resistant B6.H2g7 mice, unstimulated

Y185-p - ERK2 (mouse)
Modsite: HtGFLtEyVAtRWYR SwissProt Entrez-Gene
Orthologous residues
ERK2 (human): Y187‑p, ERK2 (mouse): Y185‑p, ERK2 (rat): Y185‑p, ERK2 (chicken): Y195‑p, ERK2 (cow): Y187‑p
Characterization
Methods used to characterize site in vivo mass spectrometry
Relevant cell lines - cell types - tissues:  T lymphocyte-lymph node
Cellular systems studied:  primary cells
Species studied:  mouse
Comments:  CD4+ T cells from diabetes-prone NOD mice, anti-CD3-stimulated, CD4+ T cells from diabetes-prone NOD mice, unstimulated, CD4+ T cells from diabetes-resistant B6.H2g7 mice, anti-CD3-stimulated, CD4+ T cells from diabetes-resistant B6.H2g7 mice, unstimulated

Y420-p - Fyn (mouse)
Modsite: RLIEDNEytARQGAK SwissProt Entrez-Gene
Orthologous residues
Fyn (human): Y420‑p, Fyn iso2 (human): Y417‑p, Fyn iso3 (human): Y365‑p, Fyn (mouse): Y420‑p, Fyn (rat): Y420‑p
Characterization
Methods used to characterize site in vivo mass spectrometry
Relevant cell lines - cell types - tissues:  T lymphocyte-lymph node
Cellular systems studied:  primary cells
Species studied:  mouse
Comments:  CD4+ T cells from diabetes-prone NOD mice, anti-CD3-stimulated, CD4+ T cells from diabetes-prone NOD mice, unstimulated, CD4+ T cells from diabetes-resistant B6.H2g7 mice, anti-CD3-stimulated, CD4+ T cells from diabetes-resistant B6.H2g7 mice, unstimulated
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
anti-CD3 decrease

Y279-p - GSK3A (mouse)
Modsite: RGEPNVsyICsRYYR SwissProt Entrez-Gene
Orthologous residues
GSK3A (human): Y279‑p, GSK3A (mouse): Y279‑p, GSK3A (rat): Y279‑p, GSK3A (cow): Y279‑p
Characterization
Methods used to characterize site in vivo mass spectrometry
Relevant cell lines - cell types - tissues:  T lymphocyte-lymph node
Cellular systems studied:  primary cells
Species studied:  mouse
Comments:  CD4+ T cells from diabetes-prone NOD mice, anti-CD3-stimulated, CD4+ T cells from diabetes-prone NOD mice, unstimulated, CD4+ T cells from diabetes-resistant B6.H2g7 mice, anti-CD3-stimulated, CD4+ T cells from diabetes-resistant B6.H2g7 mice, unstimulated

Y216-p - GSK3B (mouse)
Modsite: RGEPNVsyICsRYYR SwissProt Entrez-Gene
Orthologous residues
GSK3B (human): Y216‑p, GSK3B iso2 (human): Y216‑p, GSK3B (mouse): Y216‑p, GSK3B (rat): Y216‑p, GSK3B (rabbit): Y216‑p
Characterization
Methods used to characterize site in vivo mass spectrometry
Relevant cell lines - cell types - tissues:  T lymphocyte-lymph node
Cellular systems studied:  primary cells
Species studied:  mouse
Comments:  CD4+ T cells from diabetes-prone NOD mice, anti-CD3-stimulated, CD4+ T cells from diabetes-prone NOD mice, unstimulated, CD4+ T cells from diabetes-resistant B6.H2g7 mice, anti-CD3-stimulated, CD4+ T cells from diabetes-resistant B6.H2g7 mice, unstimulated

Y51-p - H4 (mouse)
Modsite: KRIsGLIyEETRGVL SwissProt Entrez-Gene
Orthologous residues
H4 (human): Y51‑p, H4 (mouse): Y51‑p, H4 (rat): Y51‑p, H4 (pig): Y51‑p, H4 (cow): Y51‑p
Characterization
Methods used to characterize site in vivo mass spectrometry
Relevant cell lines - cell types - tissues:  T lymphocyte-lymph node
Cellular systems studied:  primary cells
Species studied:  mouse
Comments:  CD4+ T cells from diabetes-prone NOD mice, anti-CD3-stimulated, CD4+ T cells from diabetes-prone NOD mice, unstimulated, CD4+ T cells from diabetes-resistant B6.H2g7 mice, anti-CD3-stimulated, CD4+ T cells from diabetes-resistant B6.H2g7 mice, unstimulated

Y52-p - H4H4 (mouse)
Modsite: KRIsGLIyEETRGVL SwissProt Entrez-Gene
Orthologous residues
H4H4 (human): Y52‑p, H4H4 (mouse): Y52‑p
Characterization
Methods used to characterize site in vivo mass spectrometry
Relevant cell lines - cell types - tissues:  T lymphocyte-lymph node
Cellular systems studied:  primary cells
Species studied:  mouse
Comments:  CD4+ T cells from diabetes-prone NOD mice, anti-CD3-stimulated, CD4+ T cells from diabetes-prone NOD mice, unstimulated, CD4+ T cells from diabetes-resistant B6.H2g7 mice, anti-CD3-stimulated, CD4+ T cells from diabetes-resistant B6.H2g7 mice, unstimulated

Y517-p - ITK (mouse)
Modsite: RFVLDDQyTSSTGTK SwissProt Entrez-Gene
Orthologous residues
ITK (human): Y512‑p, ITK (mouse): Y517‑p
Characterization
Methods used to characterize site in vivo mass spectrometry
Relevant cell lines - cell types - tissues:  T lymphocyte-lymph node
Cellular systems studied:  primary cells
Species studied:  mouse
Comments:  CD4+ T cells from diabetes-prone NOD mice, anti-CD3-stimulated, CD4+ T cells from diabetes-prone NOD mice, unstimulated, CD4+ T cells from diabetes-resistant B6.H2g7 mice, anti-CD3-stimulated, CD4+ T cells from diabetes-resistant B6.H2g7 mice, unstimulated

Y554-p - ITSN2 (mouse)
Modsite: EYQNKLIyLVPEKQL SwissProt Entrez-Gene
Orthologous residues
ITSN2 (human): Y553‑p, ITSN2 iso2 (human): Y553‑p, ITSN2 (mouse): Y554‑p, ITSN2 (rat): Y554‑p
Characterization
Methods used to characterize site in vivo mass spectrometry
Relevant cell lines - cell types - tissues:  T lymphocyte-lymph node
Cellular systems studied:  primary cells
Species studied:  mouse
Comments:  CD4+ T cells from diabetes-prone NOD mice, anti-CD3-stimulated, CD4+ T cells from diabetes-prone NOD mice, unstimulated, CD4+ T cells from diabetes-resistant B6.H2g7 mice, anti-CD3-stimulated, CD4+ T cells from diabetes-resistant B6.H2g7 mice, unstimulated

Y922-p - ITSN2 (mouse)
Modsite: RGEPEALyAAVtKKP SwissProt Entrez-Gene
Orthologous residues
ITSN2 (human): Y968‑p, ITSN2 iso2 (human): Y941‑p, ITSN2 (mouse): Y922‑p, ITSN2 (rat): Y927‑p
Characterization
Methods used to characterize site in vivo mass spectrometry
Relevant cell lines - cell types - tissues:  T lymphocyte-lymph node
Cellular systems studied:  primary cells
Species studied:  mouse
Comments:  CD4+ T cells from diabetes-prone NOD mice, anti-CD3-stimulated, CD4+ T cells from diabetes-prone NOD mice, unstimulated, CD4+ T cells from diabetes-resistant B6.H2g7 mice, anti-CD3-stimulated, CD4+ T cells from diabetes-resistant B6.H2g7 mice, unstimulated

Y320-p - JCAD (mouse)
Modsite: HRDPRGSyPTRSKDP SwissProt Entrez-Gene
Orthologous residues
JCAD (human): Y322‑p, JCAD (mouse): Y320‑p, JCAD (rat): H329‑p
Characterization
Methods used to characterize site in vivo mass spectrometry
Relevant cell lines - cell types - tissues:  T lymphocyte-lymph node
Cellular systems studied:  primary cells
Species studied:  mouse
Comments:  CD4+ T cells from diabetes-prone NOD mice, anti-CD3-stimulated, CD4+ T cells from diabetes-prone NOD mice, unstimulated, CD4+ T cells from diabetes-resistant B6.H2g7 mice, anti-CD3-stimulated, CD4+ T cells from diabetes-resistant B6.H2g7 mice, unstimulated

Y192-p - Lck (mouse)
Modsite: NLDNGGFyISPRITF SwissProt Entrez-Gene
Orthologous residues
Lck (human): Y192‑p, Lck iso3 (human): Y192‑p, Lck (mouse): Y192‑p, Lck (rat): Y192‑p
Characterization
Methods used to characterize site in vivo mass spectrometry
Relevant cell lines - cell types - tissues:  T lymphocyte-lymph node
Cellular systems studied:  primary cells
Species studied:  mouse
Comments:  CD4+ T cells from diabetes-prone NOD mice, anti-CD3-stimulated, CD4+ T cells from diabetes-prone NOD mice, unstimulated, CD4+ T cells from diabetes-resistant B6.H2g7 mice, anti-CD3-stimulated, CD4+ T cells from diabetes-resistant B6.H2g7 mice, unstimulated
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
anti-CD3 decrease

Y394-p - Lck (mouse)
Modsite: RLIEDNEytAREGAK SwissProt Entrez-Gene
Orthologous residues
Lck (human): Y394‑p, Lck iso3 (human): Y424‑p, Lck (mouse): Y394‑p, Lck (rat): Y394‑p
Characterization
Methods used to characterize site in vivo mass spectrometry
Relevant cell lines - cell types - tissues:  T lymphocyte-lymph node
Cellular systems studied:  primary cells
Species studied:  mouse
Comments:  CD4+ T cells from diabetes-prone NOD mice, anti-CD3-stimulated, CD4+ T cells from diabetes-prone NOD mice, unstimulated, CD4+ T cells from diabetes-resistant B6.H2g7 mice, anti-CD3-stimulated, CD4+ T cells from diabetes-resistant B6.H2g7 mice, unstimulated
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
anti-CD3 decrease

Y505-p - Lck (mouse)
Modsite: FTATEGQyQPQP___ SwissProt Entrez-Gene
Orthologous residues
Lck (human): Y505‑p, Lck iso3 (human): Y535‑p, Lck (mouse): Y505‑p, Lck (rat): Y505‑p
Characterization
Methods used to characterize site in vivo mass spectrometry
Relevant cell lines - cell types - tissues:  T lymphocyte-lymph node
Cellular systems studied:  primary cells
Species studied:  mouse
Comments:  CD4+ T cells from diabetes-prone NOD mice, anti-CD3-stimulated, CD4+ T cells from diabetes-prone NOD mice, unstimulated, CD4+ T cells from diabetes-resistant B6.H2g7 mice, anti-CD3-stimulated, CD4+ T cells from diabetes-resistant B6.H2g7 mice, unstimulated

Y207-p - LIME1 (mouse)
Modsite: ATQMDVLySRVCKPK SwissProt Entrez-Gene
Orthologous residues
LIME1 (human): Y200‑p, LIME1 (mouse): Y207‑p
Characterization
Methods used to characterize site in vivo mass spectrometry
Relevant cell lines - cell types - tissues:  T lymphocyte-lymph node
Cellular systems studied:  primary cells
Species studied:  mouse
Comments:  CD4+ T cells from diabetes-prone NOD mice, anti-CD3-stimulated, CD4+ T cells from diabetes-prone NOD mice, unstimulated, CD4+ T cells from diabetes-resistant B6.H2g7 mice, anti-CD3-stimulated, CD4+ T cells from diabetes-resistant B6.H2g7 mice, unstimulated

Y261-p - LIME1 (mouse)
Modsite: QGPLENVyESIKEMG SwissProt Entrez-Gene
Orthologous residues
LIME1 (human): Y254‑p, LIME1 (mouse): Y261‑p
Characterization
Methods used to characterize site in vivo mass spectrometry
Relevant cell lines - cell types - tissues:  T lymphocyte-lymph node
Cellular systems studied:  primary cells
Species studied:  mouse
Comments:  CD4+ T cells from diabetes-prone NOD mice, anti-CD3-stimulated, CD4+ T cells from diabetes-prone NOD mice, unstimulated, CD4+ T cells from diabetes-resistant B6.H2g7 mice, anti-CD3-stimulated, CD4+ T cells from diabetes-resistant B6.H2g7 mice, unstimulated

Y433-p - MST1 (mouse)
Modsite: KIPQDGDyEFLKsWT SwissProt Entrez-Gene
Orthologous residues
MST1 (human): Y433‑p, MST1 iso2 (human): Y433‑p, MST1 (mouse): Y433‑p, MST1 (rat): Y433‑p
Characterization
Methods used to characterize site in vivo mass spectrometry
Relevant cell lines - cell types - tissues:  T lymphocyte-lymph node
Cellular systems studied:  primary cells
Species studied:  mouse
Comments:  CD4+ T cells from diabetes-prone NOD mice, anti-CD3-stimulated, CD4+ T cells from diabetes-prone NOD mice, unstimulated, CD4+ T cells from diabetes-resistant B6.H2g7 mice, anti-CD3-stimulated, CD4+ T cells from diabetes-resistant B6.H2g7 mice, unstimulated

Y182-p - P38A (mouse)
Modsite: tDDEMtGyVAtRWYR SwissProt Entrez-Gene
Orthologous residues
P38A (human): Y182‑p, P38A iso2 (human): Y182‑p, P38A (mouse): Y182‑p, P38A iso3 (mouse): Y182‑p, P38A (rat): Y182‑p, P38A (salmonid): Y183‑p
Characterization
Methods used to characterize site in vivo mass spectrometry
Relevant cell lines - cell types - tissues:  T lymphocyte-lymph node
Cellular systems studied:  primary cells
Species studied:  mouse
Comments:  CD4+ T cells from diabetes-prone NOD mice, anti-CD3-stimulated, CD4+ T cells from diabetes-prone NOD mice, unstimulated, CD4+ T cells from diabetes-resistant B6.H2g7 mice, anti-CD3-stimulated, CD4+ T cells from diabetes-resistant B6.H2g7 mice, unstimulated

Y165-p - PAG (mouse)
Modsite: GPGVEGPyEVLKDss SwissProt Entrez-Gene
Orthologous residues
PAG (human): Y163‑p, PAG (mouse): Y165‑p, PAG (rat): Y165‑p
Characterization
Methods used to characterize site in vivo mass spectrometry
Relevant cell lines - cell types - tissues:  T lymphocyte-lymph node
Cellular systems studied:  primary cells
Species studied:  mouse
Comments:  CD4+ T cells from diabetes-prone NOD mice, anti-CD3-stimulated, CD4+ T cells from diabetes-prone NOD mice, unstimulated, CD4+ T cells from diabetes-resistant B6.H2g7 mice, anti-CD3-stimulated, CD4+ T cells from diabetes-resistant B6.H2g7 mice, unstimulated

Y224-p - PAG (mouse)
Modsite: GKADFAEyASVDRNK SwissProt Entrez-Gene
Orthologous residues
PAG (human): Y227‑p, PAG (mouse): Y224‑p, PAG (rat): Y224‑p
Characterization
Methods used to characterize site in vivo mass spectrometry
Relevant cell lines - cell types - tissues:  T lymphocyte-lymph node
Cellular systems studied:  primary cells
Species studied:  mouse
Comments:  CD4+ T cells from diabetes-prone NOD mice, anti-CD3-stimulated, CD4+ T cells from diabetes-prone NOD mice, unstimulated, CD4+ T cells from diabetes-resistant B6.H2g7 mice, anti-CD3-stimulated, CD4+ T cells from diabetes-resistant B6.H2g7 mice, unstimulated
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
anti-CD3 decrease

Y356-p - PAG (mouse)
Modsite: SSsCNDLyAtVKDFE SwissProt Entrez-Gene
Orthologous residues
PAG (human): Y359‑p, PAG (mouse): Y356‑p, PAG (rat): Y351‑p
Characterization
Methods used to characterize site in vivo mass spectrometry
Relevant cell lines - cell types - tissues:  T lymphocyte-lymph node
Cellular systems studied:  primary cells
Species studied:  mouse
Comments:  CD4+ T cells from diabetes-prone NOD mice, anti-CD3-stimulated, CD4+ T cells from diabetes-prone NOD mice, unstimulated, CD4+ T cells from diabetes-resistant B6.H2g7 mice, anti-CD3-stimulated, CD4+ T cells from diabetes-resistant B6.H2g7 mice, unstimulated

Y523-p - PIK3CD (mouse)
Modsite: RRGsGELyEHEKDLV SwissProt Entrez-Gene
Orthologous residues
PIK3CD (human): Y524‑p, PIK3CD (mouse): Y523‑p, PIK3CD (rat):
Characterization
Methods used to characterize site in vivo mass spectrometry
Relevant cell lines - cell types - tissues:  T lymphocyte-lymph node
Cellular systems studied:  primary cells
Species studied:  mouse
Comments:  CD4+ T cells from diabetes-prone NOD mice, anti-CD3-stimulated, CD4+ T cells from diabetes-prone NOD mice, unstimulated, CD4+ T cells from diabetes-resistant B6.H2g7 mice, anti-CD3-stimulated, CD4+ T cells from diabetes-resistant B6.H2g7 mice, unstimulated

Y467-p - PIK3R1 (mouse)
Modsite: SREyDRLyEEyTRTS SwissProt Entrez-Gene
Orthologous residues
PIK3R1 (human): Y467‑p, PIK3R1 iso2 (human): Y197‑p, PIK3R1 (mouse): Y467‑p, PIK3R1 (rat): Y467‑p, PIK3R1 (cow): Y467‑p
Characterization
Methods used to characterize site in vivo mass spectrometry
Relevant cell lines - cell types - tissues:  T lymphocyte-lymph node
Cellular systems studied:  primary cells
Species studied:  mouse
Comments:  CD4+ T cells from diabetes-prone NOD mice, anti-CD3-stimulated, CD4+ T cells from diabetes-prone NOD mice, unstimulated, CD4+ T cells from diabetes-resistant B6.H2g7 mice, anti-CD3-stimulated, CD4+ T cells from diabetes-resistant B6.H2g7 mice, unstimulated

Y199-p - PIK3R3 (mouse)
Modsite: SKEyDRLyEEytRTS SwissProt Entrez-Gene
Orthologous residues
PIK3R3 (human): Y199‑p, PIK3R3 iso2 (human): Y199‑p, PIK3R3 iso3 (human): Y245‑p, PIK3R3 (mouse): Y199‑p, PIK3R3 (rat): Y199‑p
Characterization
Methods used to characterize site in vivo mass spectrometry
Relevant cell lines - cell types - tissues:  T lymphocyte-lymph node
Cellular systems studied:  primary cells
Species studied:  mouse
Comments:  CD4+ T cells from diabetes-prone NOD mice, anti-CD3-stimulated, CD4+ T cells from diabetes-prone NOD mice, unstimulated, CD4+ T cells from diabetes-resistant B6.H2g7 mice, anti-CD3-stimulated, CD4+ T cells from diabetes-resistant B6.H2g7 mice, unstimulated

Y311-p - PKCD (mouse)
Modsite: TTEsVGIyQGFEKKP SwissProt Entrez-Gene
Orthologous residues
PKCD (human): Y313‑p, PKCD iso2 (human): Y313‑p, PKCD (mouse): Y311‑p, PKCD iso2 (mouse): Y311‑p, PKCD (rat): Y311‑p
Characterization
Methods used to characterize site in vivo mass spectrometry
Relevant cell lines - cell types - tissues:  T lymphocyte-lymph node
Cellular systems studied:  primary cells
Species studied:  mouse
Comments:  CD4+ T cells from diabetes-prone NOD mice, anti-CD3-stimulated, CD4+ T cells from diabetes-prone NOD mice, unstimulated, CD4+ T cells from diabetes-resistant B6.H2g7 mice, anti-CD3-stimulated, CD4+ T cells from diabetes-resistant B6.H2g7 mice, unstimulated

Y771-p - PLCG1 (mouse)
Modsite: IGTAEPDyGALyEGR SwissProt Entrez-Gene
Orthologous residues
PLCG1 (human): Y771‑p, PLCG1 iso2 (human): Y771‑p, PLCG1 (mouse): Y771‑p, PLCG1 (rat): Y771‑p, PLCG1 (cow): Y771‑p
Characterization
Methods used to characterize site in vivo mass spectrometry
Relevant cell lines - cell types - tissues:  T lymphocyte-lymph node
Cellular systems studied:  primary cells
Species studied:  mouse
Comments:  CD4+ T cells from diabetes-prone NOD mice, anti-CD3-stimulated, CD4+ T cells from diabetes-prone NOD mice, unstimulated, CD4+ T cells from diabetes-resistant B6.H2g7 mice, anti-CD3-stimulated, CD4+ T cells from diabetes-resistant B6.H2g7 mice, unstimulated
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
anti-CD3 increase

Y849-p - PRP4 (mouse)
Modsite: ADNDItPyLVsRFYR SwissProt Entrez-Gene
Orthologous residues
PRP4 (human): Y849‑p, PRP4 (mouse): Y849‑p, PRP4 (rat): Y849‑p
Characterization
Methods used to characterize site in vivo mass spectrometry
Relevant cell lines - cell types - tissues:  T lymphocyte-lymph node
Cellular systems studied:  primary cells
Species studied:  mouse
Comments:  CD4+ T cells from diabetes-prone NOD mice, anti-CD3-stimulated, CD4+ T cells from diabetes-prone NOD mice, unstimulated, CD4+ T cells from diabetes-resistant B6.H2g7 mice, anti-CD3-stimulated, CD4+ T cells from diabetes-resistant B6.H2g7 mice, unstimulated

Y825-p - PTPRA (mouse)
Modsite: YIDAFsDyANFK___ SwissProt Entrez-Gene
Orthologous residues
PTPRA (human): Y798‑p, PTPRA iso2 (human): Y789‑p, PTPRA (mouse): Y825‑p, PTPRA (rat): Y792‑p
Characterization
Methods used to characterize site in vivo mass spectrometry
Relevant cell lines - cell types - tissues:  T lymphocyte-lymph node
Cellular systems studied:  primary cells
Species studied:  mouse
Comments:  CD4+ T cells from diabetes-prone NOD mice, anti-CD3-stimulated, CD4+ T cells from diabetes-prone NOD mice, unstimulated, CD4+ T cells from diabetes-resistant B6.H2g7 mice, anti-CD3-stimulated, CD4+ T cells from diabetes-resistant B6.H2g7 mice, unstimulated

Y118-p - PXN (mouse)
Modsite: AGEEEHVysFPNKQk SwissProt Entrez-Gene
Orthologous residues
PXN (human): Y118‑p, PXN iso2 (human): Y118‑p, PXN iso3 (human): Y118‑p, PXN iso6 (human): Y125‑p, PXN (mouse): Y118‑p, PXN iso2 (mouse): Y118‑p, PXN (rat): Y118‑p, PXN (chicken): Y118‑p, PXN (cow): Y112‑p
Characterization
Methods used to characterize site in vivo mass spectrometry
Relevant cell lines - cell types - tissues:  T lymphocyte-lymph node
Cellular systems studied:  primary cells
Species studied:  mouse
Comments:  CD4+ T cells from diabetes-prone NOD mice, anti-CD3-stimulated, CD4+ T cells from diabetes-prone NOD mice, unstimulated, CD4+ T cells from diabetes-resistant B6.H2g7 mice, anti-CD3-stimulated, CD4+ T cells from diabetes-resistant B6.H2g7 mice, unstimulated
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
anti-CD3 decrease

Y579-p - Pyk2 (mouse)
Modsite: RyIEDEDyyKASVTR SwissProt Entrez-Gene
Orthologous residues
Pyk2 (human): Y579‑p, Pyk2 iso2 (human): Y579‑p, Pyk2 (mouse): Y579‑p, Pyk2 (rat): Y579‑p
Characterization
Methods used to characterize site in vivo mass spectrometry
Relevant cell lines - cell types - tissues:  T lymphocyte-lymph node
Cellular systems studied:  primary cells
Species studied:  mouse
Comments:  CD4+ T cells from diabetes-prone NOD mice, anti-CD3-stimulated, CD4+ T cells from diabetes-prone NOD mice, unstimulated, CD4+ T cells from diabetes-resistant B6.H2g7 mice, anti-CD3-stimulated, CD4+ T cells from diabetes-resistant B6.H2g7 mice, unstimulated
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
anti-CD3 increase

Y580-p - Pyk2 (mouse)
Modsite: yIEDEDyyKASVTRL SwissProt Entrez-Gene
Orthologous residues
Pyk2 (human): Y580‑p, Pyk2 iso2 (human): Y580‑p, Pyk2 (mouse): Y580‑p, Pyk2 (rat): Y580‑p
Characterization
Methods used to characterize site in vivo mass spectrometry
Relevant cell lines - cell types - tissues:  T lymphocyte-lymph node
Cellular systems studied:  primary cells
Species studied:  mouse
Comments:  CD4+ T cells from diabetes-prone NOD mice, anti-CD3-stimulated, CD4+ T cells from diabetes-prone NOD mice, unstimulated, CD4+ T cells from diabetes-resistant B6.H2g7 mice, anti-CD3-stimulated, CD4+ T cells from diabetes-resistant B6.H2g7 mice, unstimulated

Y328-p - RBCK1 (mouse)
Modsite: CPFIDsTysCPGKLL SwissProt Entrez-Gene
Orthologous residues
RBCK1 (human): Y330‑p, RBCK1 iso3 (human): Y288‑p, RBCK1 iso4 (human): , RBCK1 (mouse): Y328‑p, RBCK1 (rat): Y328‑p
Characterization
Methods used to characterize site in vivo mass spectrometry
Relevant cell lines - cell types - tissues:  T lymphocyte-lymph node
Cellular systems studied:  primary cells
Species studied:  mouse
Comments:  CD4+ T cells from diabetes-prone NOD mice, anti-CD3-stimulated, CD4+ T cells from diabetes-prone NOD mice, unstimulated, CD4+ T cells from diabetes-resistant B6.H2g7 mice, anti-CD3-stimulated, CD4+ T cells from diabetes-resistant B6.H2g7 mice, unstimulated
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
anti-CD3 increase

Y139-p - RPSA (mouse)
Modsite: QPLTEAsyVNLPTIA SwissProt Entrez-Gene
Orthologous residues
RPSA (human): Y139‑p, RPSA (mouse): Y139‑p, RPSA (rat): Y139‑p
Characterization
Methods used to characterize site in vivo mass spectrometry
Relevant cell lines - cell types - tissues:  T lymphocyte-lymph node
Cellular systems studied:  primary cells
Species studied:  mouse
Comments:  CD4+ T cells from diabetes-prone NOD mice, anti-CD3-stimulated, CD4+ T cells from diabetes-prone NOD mice, unstimulated, CD4+ T cells from diabetes-resistant B6.H2g7 mice, anti-CD3-stimulated, CD4+ T cells from diabetes-resistant B6.H2g7 mice, unstimulated

Y423-p - SHC1 (mouse)
Modsite: ELFDDPsyVNIQNLD SwissProt Entrez-Gene
Orthologous residues
SHC1 (human): Y427‑p, SHC1 iso2 (human): Y317‑p, SHC1 iso3 (human): Y272‑p, SHC1 iso6 (human): Y428‑p, SHC1 iso7 (human): Y318‑p, SHC1 (mouse): Y423‑p, SHC1 iso2 (mouse): Y313‑p, SHC1 iso3 (mouse): Y268‑p, SHC1 (rat): Y423‑p, SHC1 iso2 (rat): Y313‑p
Characterization
Methods used to characterize site in vivo mass spectrometry
Relevant cell lines - cell types - tissues:  T lymphocyte-lymph node
Cellular systems studied:  primary cells
Species studied:  mouse
Comments:  CD4+ T cells from diabetes-prone NOD mice, anti-CD3-stimulated, CD4+ T cells from diabetes-prone NOD mice, unstimulated, CD4+ T cells from diabetes-resistant B6.H2g7 mice, anti-CD3-stimulated, CD4+ T cells from diabetes-resistant B6.H2g7 mice, unstimulated
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
anti-CD3 increase

Y536-p - SHP-1 (mouse)
Modsite: QKGQEsEyGNItyPP SwissProt Entrez-Gene
Orthologous residues
SHP‑1 (human): Y536‑p, SHP‑1 iso2 (human): Y497‑p, SHP‑1 iso4 (human): Y536‑p, SHP‑1 (mouse): Y536‑p, SHP‑1 (rat): Y538‑p
Characterization
Methods used to characterize site in vivo mass spectrometry
Relevant cell lines - cell types - tissues:  T lymphocyte-lymph node
Cellular systems studied:  primary cells
Species studied:  mouse
Comments:  CD4+ T cells from diabetes-prone NOD mice, anti-CD3-stimulated, CD4+ T cells from diabetes-prone NOD mice, unstimulated, CD4+ T cells from diabetes-resistant B6.H2g7 mice, anti-CD3-stimulated, CD4+ T cells from diabetes-resistant B6.H2g7 mice, unstimulated

Y62-p - SHP-2 (mouse)
Modsite: KIQNTGDyyDLyGGE SwissProt Entrez-Gene
Orthologous residues
SHP‑2 (human): Y62‑p, SHP‑2 iso2 (human): Y62‑p, SHP‑2 (mouse): Y62‑p, SHP‑2 (rat): Y62‑p
Characterization
Methods used to characterize site in vivo mass spectrometry
Relevant cell lines - cell types - tissues:  T lymphocyte-lymph node
Cellular systems studied:  primary cells
Species studied:  mouse
Comments:  CD4+ T cells from diabetes-prone NOD mice, anti-CD3-stimulated, CD4+ T cells from diabetes-prone NOD mice, unstimulated, CD4+ T cells from diabetes-resistant B6.H2g7 mice, anti-CD3-stimulated, CD4+ T cells from diabetes-resistant B6.H2g7 mice, unstimulated

Y584-p - SHP-2 (mouse)
Modsite: REDsARVyENVGLMQ SwissProt Entrez-Gene
Orthologous residues
SHP‑2 (human): Y584‑p, SHP‑2 iso2 (human): Y580‑p, SHP‑2 (mouse): Y584‑p, SHP‑2 (rat): Y584‑p
Characterization
Methods used to characterize site in vivo mass spectrometry
Relevant cell lines - cell types - tissues:  T lymphocyte-lymph node
Cellular systems studied:  primary cells
Species studied:  mouse
Comments:  CD4+ T cells from diabetes-prone NOD mice, anti-CD3-stimulated, CD4+ T cells from diabetes-prone NOD mice, unstimulated, CD4+ T cells from diabetes-resistant B6.H2g7 mice, anti-CD3-stimulated, CD4+ T cells from diabetes-resistant B6.H2g7 mice, unstimulated

Y169-p - SKAP2 (mouse)
Modsite: GEFAIDGyDVRMNNT SwissProt Entrez-Gene
Orthologous residues
SKAP2 (human): Y169‑p, SKAP2 (mouse): Y169‑p, SKAP2 (rat): Y169‑p
Characterization
Methods used to characterize site in vivo mass spectrometry
Relevant cell lines - cell types - tissues:  T lymphocyte-lymph node
Cellular systems studied:  primary cells
Species studied:  mouse
Comments:  CD4+ T cells from diabetes-prone NOD mice, anti-CD3-stimulated, CD4+ T cells from diabetes-prone NOD mice, unstimulated, CD4+ T cells from diabetes-resistant B6.H2g7 mice, anti-CD3-stimulated, CD4+ T cells from diabetes-resistant B6.H2g7 mice, unstimulated

Y260-p - SKAP2 (mouse)
Modsite: QPIDDEIyEELPEEE SwissProt Entrez-Gene
Orthologous residues
SKAP2 (human): Y261‑p, SKAP2 (mouse): Y260‑p, SKAP2 (rat): Y260‑p
Characterization
Methods used to characterize site in vivo mass spectrometry
Relevant cell lines - cell types - tissues:  T lymphocyte-lymph node
Cellular systems studied:  primary cells
Species studied:  mouse
Comments:  CD4+ T cells from diabetes-prone NOD mice, anti-CD3-stimulated, CD4+ T cells from diabetes-prone NOD mice, unstimulated, CD4+ T cells from diabetes-resistant B6.H2g7 mice, anti-CD3-stimulated, CD4+ T cells from diabetes-resistant B6.H2g7 mice, unstimulated

Y142-p - SKAP55 (mouse)
Modsite: ISRGLFLyYANEKSK SwissProt Entrez-Gene
Orthologous residues
SKAP55 (human): Y142‑p, SKAP55 (mouse): Y142‑p, SKAP55 (rat): Y142‑p
Characterization
Methods used to characterize site in vivo mass spectrometry
Relevant cell lines - cell types - tissues:  T lymphocyte-lymph node
Cellular systems studied:  primary cells
Species studied:  mouse
Comments:  CD4+ T cells from diabetes-prone NOD mice, anti-CD3-stimulated, CD4+ T cells from diabetes-prone NOD mice, unstimulated, CD4+ T cells from diabetes-resistant B6.H2g7 mice, anti-CD3-stimulated, CD4+ T cells from diabetes-resistant B6.H2g7 mice, unstimulated
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
anti-CD3 decrease

Y268-p - SKAP55 (mouse)
Modsite: TEKEEDIyEVLPDDD SwissProt Entrez-Gene
Orthologous residues
SKAP55 (human): Y271‑p, SKAP55 (mouse): Y268‑p, SKAP55 (rat): Y267‑p
Characterization
Methods used to characterize site in vivo mass spectrometry
Relevant cell lines - cell types - tissues:  T lymphocyte-lymph node
Cellular systems studied:  primary cells
Species studied:  mouse
Comments:  CD4+ T cells from diabetes-prone NOD mice, anti-CD3-stimulated, CD4+ T cells from diabetes-prone NOD mice, unstimulated, CD4+ T cells from diabetes-resistant B6.H2g7 mice, anti-CD3-stimulated, CD4+ T cells from diabetes-resistant B6.H2g7 mice, unstimulated

Y319-p - SLAMF6 (mouse)
Modsite: KNDSMTIysIVNHSR SwissProt Entrez-Gene
Orthologous residues
SLAMF6 (human): Y309‑p, SLAMF6 (mouse): Y319‑p, SLAMF6 iso2 (mouse): Y319‑p, SLAMF6 (rat): Y322‑p
Characterization
Methods used to characterize site in vivo mass spectrometry
Relevant cell lines - cell types - tissues:  T lymphocyte-lymph node
Cellular systems studied:  primary cells
Species studied:  mouse
Comments:  CD4+ T cells from diabetes-prone NOD mice, anti-CD3-stimulated, CD4+ T cells from diabetes-prone NOD mice, unstimulated, CD4+ T cells from diabetes-resistant B6.H2g7 mice, anti-CD3-stimulated, CD4+ T cells from diabetes-resistant B6.H2g7 mice, unstimulated

Y559-p - SLAP-130 (mouse)
Modsite: TTAVEIDyDsLKRKK SwissProt Entrez-Gene
Orthologous residues
SLAP‑130 (human): Y571‑p, SLAP‑130 iso2 (human): Y571‑p, SLAP‑130 (mouse): Y559‑p, SLAP‑130 (rat): Y560‑p
Characterization
Methods used to characterize site in vivo mass spectrometry
Relevant cell lines - cell types - tissues:  T lymphocyte-lymph node
Cellular systems studied:  primary cells
Species studied:  mouse
Comments:  CD4+ T cells from diabetes-prone NOD mice, anti-CD3-stimulated, CD4+ T cells from diabetes-prone NOD mice, unstimulated, CD4+ T cells from diabetes-resistant B6.H2g7 mice, anti-CD3-stimulated, CD4+ T cells from diabetes-resistant B6.H2g7 mice, unstimulated

Y424-p - Src (mouse)
Modsite: RLIEDNEytARQGAK SwissProt Entrez-Gene
Orthologous residues
Src (human): Y419‑p, Src iso2 (human): Y425‑p, Src (mouse): Y424‑p, Src iso2 (mouse): Y418‑p, Src (rat): Y419‑p, Src (chicken): Y416‑p
Characterization
Methods used to characterize site in vivo mass spectrometry
Relevant cell lines - cell types - tissues:  T lymphocyte-lymph node
Cellular systems studied:  primary cells
Species studied:  mouse
Comments:  CD4+ T cells from diabetes-prone NOD mice, anti-CD3-stimulated, CD4+ T cells from diabetes-prone NOD mice, unstimulated, CD4+ T cells from diabetes-resistant B6.H2g7 mice, anti-CD3-stimulated, CD4+ T cells from diabetes-resistant B6.H2g7 mice, unstimulated
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
anti-CD3 decrease

Y1116-p - talin 1 (mouse)
Modsite: IAQGNENyAGIAARD SwissProt Entrez-Gene
Orthologous residues
talin 1 (human): Y1116‑p, talin 1 (mouse): Y1116‑p, talin 1 (rat): Y1116‑p
Characterization
Methods used to characterize site in vivo mass spectrometry
Relevant cell lines - cell types - tissues:  T lymphocyte-lymph node
Cellular systems studied:  primary cells
Species studied:  mouse
Comments:  CD4+ T cells from diabetes-prone NOD mice, anti-CD3-stimulated, CD4+ T cells from diabetes-prone NOD mice, unstimulated, CD4+ T cells from diabetes-resistant B6.H2g7 mice, anti-CD3-stimulated, CD4+ T cells from diabetes-resistant B6.H2g7 mice, unstimulated

Y91-p - TXK (mouse)
Modsite: RIQVKALyDFLPREP SwissProt Entrez-Gene
Orthologous residues
TXK (human): Y91‑p, TXK (mouse): Y91‑p
Characterization
Methods used to characterize site in vivo mass spectrometry
Relevant cell lines - cell types - tissues:  T lymphocyte-lymph node
Cellular systems studied:  primary cells
Species studied:  mouse
Comments:  CD4+ T cells from diabetes-prone NOD mice, anti-CD3-stimulated, CD4+ T cells from diabetes-prone NOD mice, unstimulated, CD4+ T cells from diabetes-resistant B6.H2g7 mice, anti-CD3-stimulated, CD4+ T cells from diabetes-resistant B6.H2g7 mice, unstimulated
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
anti-CD3 increase

Y148-p - TXK (mouse)
Modsite: RLANLEIyEWYHKNI SwissProt Entrez-Gene
Orthologous residues
TXK (human): Y148‑p, TXK (mouse): Y148‑p
Characterization
Methods used to characterize site in vivo mass spectrometry
Relevant cell lines - cell types - tissues:  T lymphocyte-lymph node
Cellular systems studied:  primary cells
Species studied:  mouse
Comments:  CD4+ T cells from diabetes-prone NOD mice, anti-CD3-stimulated, CD4+ T cells from diabetes-prone NOD mice, unstimulated, CD4+ T cells from diabetes-resistant B6.H2g7 mice, anti-CD3-stimulated, CD4+ T cells from diabetes-resistant B6.H2g7 mice, unstimulated
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
anti-CD3 increase

Y214-p - TXK (mouse)
Modsite: KNDSGQWyITERHLF SwissProt Entrez-Gene
Orthologous residues
TXK (human): Y214‑p, TXK (mouse): Y214‑p
Characterization
Methods used to characterize site in vivo mass spectrometry
Relevant cell lines - cell types - tissues:  T lymphocyte-lymph node
Cellular systems studied:  primary cells
Species studied:  mouse
Comments:  CD4+ T cells from diabetes-prone NOD mice, anti-CD3-stimulated, CD4+ T cells from diabetes-prone NOD mice, unstimulated, CD4+ T cells from diabetes-resistant B6.H2g7 mice, anti-CD3-stimulated, CD4+ T cells from diabetes-resistant B6.H2g7 mice, unstimulated

Y420-p - TXK (mouse)
Modsite: RYVLDDEyISSSGAK SwissProt Entrez-Gene
Orthologous residues
TXK (human): Y420‑p, TXK (mouse): Y420‑p
Characterization
Methods used to characterize site in vivo mass spectrometry
Relevant cell lines - cell types - tissues:  T lymphocyte-lymph node
Cellular systems studied:  primary cells
Species studied:  mouse
Comments:  CD4+ T cells from diabetes-prone NOD mice, anti-CD3-stimulated, CD4+ T cells from diabetes-prone NOD mice, unstimulated, CD4+ T cells from diabetes-resistant B6.H2g7 mice, anti-CD3-stimulated, CD4+ T cells from diabetes-resistant B6.H2g7 mice, unstimulated
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
anti-CD3 decrease

Y293-p - WASP (mouse)
Modsite: AETsKLIyDFIEDQG SwissProt Entrez-Gene
Orthologous residues
WASP (human): Y291‑p, WASP (mouse): Y293‑p
Characterization
Methods used to characterize site in vivo mass spectrometry
Relevant cell lines - cell types - tissues:  T lymphocyte-lymph node
Cellular systems studied:  primary cells
Species studied:  mouse
Comments:  CD4+ T cells from diabetes-prone NOD mice, anti-CD3-stimulated, CD4+ T cells from diabetes-prone NOD mice, unstimulated, CD4+ T cells from diabetes-resistant B6.H2g7 mice, anti-CD3-stimulated, CD4+ T cells from diabetes-resistant B6.H2g7 mice, unstimulated
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
anti-CD3 decrease

Y424-p - Yes (mouse)
Modsite: RLIEDNEytARQGAK SwissProt Entrez-Gene
Orthologous residues
Yes (human): Y426‑p, Yes (mouse): Y424‑p, Yes (rat): Y424‑p
Characterization
Methods used to characterize site in vivo mass spectrometry
Relevant cell lines - cell types - tissues:  T lymphocyte-lymph node
Cellular systems studied:  primary cells
Species studied:  mouse
Comments:  CD4+ T cells from diabetes-prone NOD mice, anti-CD3-stimulated, CD4+ T cells from diabetes-prone NOD mice, unstimulated, CD4+ T cells from diabetes-resistant B6.H2g7 mice, anti-CD3-stimulated, CD4+ T cells from diabetes-resistant B6.H2g7 mice, unstimulated
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
anti-CD3 decrease

Y290-p - ZAP70 (mouse)
Modsite: DTLNSDGyTPEPARL SwissProt Entrez-Gene
Orthologous residues
ZAP70 (human): Y292‑p, ZAP70 (mouse): Y290‑p, ZAP70 (rat): Y290‑p
Characterization
Methods used to characterize site in vivo mass spectrometry
Relevant cell lines - cell types - tissues:  T lymphocyte-lymph node
Cellular systems studied:  primary cells
Species studied:  mouse
Comments:  CD4+ T cells from diabetes-prone NOD mice, anti-CD3-stimulated, CD4+ T cells from diabetes-prone NOD mice, unstimulated, CD4+ T cells from diabetes-resistant B6.H2g7 mice, anti-CD3-stimulated, CD4+ T cells from diabetes-resistant B6.H2g7 mice, unstimulated
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
anti-CD3 increase

Y491-p - ZAP70 (mouse)
Modsite: ALGADDsyyTARSAG SwissProt Entrez-Gene
Orthologous residues
ZAP70 (human): Y492‑p, ZAP70 (mouse): Y491‑p, ZAP70 (rat): Y487‑p
Characterization
Methods used to characterize site in vivo mass spectrometry
Relevant cell lines - cell types - tissues:  T lymphocyte-lymph node
Cellular systems studied:  primary cells
Species studied:  mouse
Comments:  CD4+ T cells from diabetes-prone NOD mice, anti-CD3-stimulated, CD4+ T cells from diabetes-prone NOD mice, unstimulated, CD4+ T cells from diabetes-resistant B6.H2g7 mice, anti-CD3-stimulated, CD4+ T cells from diabetes-resistant B6.H2g7 mice, unstimulated
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
anti-CD3 increase