Curated Information
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Home > Curated Information Page > PubMed Id: 20156337
Lynch JT, et al. (2010) The role of glucocorticoid receptor phosphorylation in Mcl-1 and NOXA gene expression. Mol Cancer 9, 38 20156337
This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2015, 43:D512-20). To learn more about the scope of PhosphoSitePlus®, click here.
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S211-p - GR (human)
Modsite: PGkEtNEsPWRSDLL SwissProt Entrez-Gene
Orthologous residues
GR (human): S211‑p, GR iso2 (human): S211‑p, GR iso10 (human): S211‑p, GR (mouse): S220‑p, GR (rat): S232‑p
Characterization
Methods used to characterize site in vivo phospho-antibody, western blotting
Disease tissue studied:  lung cancer
Relevant cell lines - cell types - tissues:  A549 (pulmonary), CEM-C1-15, CEM-C7-14
Cellular systems studied:  cell lines
Species studied:  human
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
dexamethasone increase CEM-C7-14, CEM-C1-15, and A549 cells
UV dexamethasone no effect upon treatment-induced increase CEM-C7-14, CEM-C1-15, and A549 cells
SP600125 dexamethasone no effect upon treatment-induced increase CEM-C7-14, CEM-C1-15, and A549 cells
UV increase in CEM-C7-14 cells. no increase in CEM-C1-15 and A549 cells

S226-p - GR (human)
Modsite: IDENCLLsPLAGEDD SwissProt Entrez-Gene
Orthologous residues
GR (human): S226‑p, GR iso2 (human): S226‑p, GR iso10 (human): S226‑p, GR (mouse): S234‑p, GR (rat): S246‑p
Characterization
Methods used to characterize site in vivo phospho-antibody, western blotting
Disease tissue studied:  lung cancer
Relevant cell lines - cell types - tissues:  A549 (pulmonary), CEM-C1-15, CEM-C7-14
Cellular systems studied:  cell lines
Species studied:  human
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
dexamethasone no change compared to control CEM-C7-14 cells
UV no change compared to control CEM-C7-14 cells
dexamethasone, UV no change compared to control CEM-C7-14 cells
SP600125, dexamethasone no change compared to control CEM-C7-14 cells
dexamethasone increase A549 cells
UV dexamethasone augment treatment-induced increase A549 cells
UV increase A549 cells
SP600125 dexamethasone no effect upon treatment-induced increase A549 cells
dexamethasone decrease CEM-C1-15 cells
UV dexamethasone inhibit treatment-induced decrease CEM-C1-15 cells
UV increase CEM-C1-15 cells
SP600125 dexamethasone no effect upon treatment-induced decrease CEM-C1-15 cells

T183-p - JNK1 (human)
Modsite: AGtsFMMtPyVVtRY SwissProt Entrez-Gene
Orthologous residues
JNK1 (human): T183‑p, JNK1 iso2 (human): T183‑p, JNK1 iso3 (human): T183‑p, JNK1 (mouse): T183‑p, JNK1 (rat): T183‑p
Characterization
Methods used to characterize site in vivo phospho-antibody, western blotting
Disease tissue studied:  lung cancer
Relevant cell lines - cell types - tissues:  A549 (pulmonary), CEM-C1-15, CEM-C7-14
Cellular systems studied:  cell lines
Species studied:  human
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
dexamethasone no change compared to control
UV no change compared to control

Y185-p - JNK1 (human)
Modsite: tsFMMtPyVVtRYYR SwissProt Entrez-Gene
Orthologous residues
JNK1 (human): Y185‑p, JNK1 iso2 (human): Y185‑p, JNK1 iso3 (human): Y185‑p, JNK1 (mouse): Y185‑p, JNK1 (rat): Y185‑p
Characterization
Methods used to characterize site in vivo phospho-antibody, western blotting
Disease tissue studied:  lung cancer
Relevant cell lines - cell types - tissues:  A549 (pulmonary), CEM-C1-15, CEM-C7-14
Cellular systems studied:  cell lines
Species studied:  human
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
dexamethasone no change compared to control
UV no change compared to control