Gibson RM, et al. (2000) Phosphorylation of human gp130 at Ser-782 adjacent to the Di-leucine internalization motif. Effects on expression and signaling. J Biol Chem 275, 22574-82 10811661

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S782-p - gp130 (human) ▲

Modsite: QVFSRsEsTQPLLDS SwissProt Entrez-Gene Orthologous residues gp130 (human): S782‑p, gp130 iso2 (human): ‑, gp130 iso3 (human): S721‑p, gp130 (mouse): S780‑p, gp130 (rat): S781‑p Characterization Methods used to characterize site in vivo:  [32P] bio-synthetic labeling, mass spectrometry, mutation of modification site, peptide sequencing Relevant cell lines - cell types - tissues:  3T3 (fibroblast) [SHP-2 (mouse), homozygous knockout], COS (fibroblast) Cellular systems studied:  cell lines Species studied:  green monkey, mouse Upstream Regulation Treatments, proteins and their effect on site modification:  Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes LIF increase phorbol_ester increase Downstream Regulation Effect of modification (function):  receptor internalization, altered