Schmitz J, et al. (2000) The cytoplasmic tyrosine motifs in full-length glycoprotein 130 have different roles in IL-6 signal transduction. J Immunol 164, 848-54 10623831

This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2015, 43:D512-20). To learn more about the scope of PhosphoSitePlus®, click here.

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Y767-p - gp130 (human) ▲

Modsite: StVVHsGyRHQVPSV SwissProt Entrez-Gene Orthologous residues gp130 (human): Y767‑p, gp130 iso2 (human): ‑, gp130 iso3 (human): Y706‑p, gp130 (mouse): Y765‑p, gp130 (rat): Y766‑p Characterization Methods used to characterize site in vivo:  mutation of modification site Relevant cell lines - cell types - tissues:  BaF3 ('B lymphocyte, precursor'), HepG2 (hepatic) Cellular systems studied:  cell lines Species studied:  human, mouse Downstream Regulation Effect of modification (process):  cell cycle regulation, transcription, altered

Y814-p - gp130 (human) ▲

Modsite: GILPRQQyFKQNCsQ SwissProt Entrez-Gene Orthologous residues gp130 (human): Y814‑p, gp130 iso2 (human): ‑, gp130 iso3 (human): Y753‑p, gp130 (mouse): Y812‑p, gp130 (rat): Y813‑p Characterization Methods used to characterize site in vivo:  mutation of modification site Relevant cell lines - cell types - tissues:  BaF3 ('B lymphocyte, precursor'), HepG2 (hepatic) Cellular systems studied:  cell lines Species studied:  human, mouse Downstream Regulation Effect of modification (process):  cell cycle regulation, transcription, altered

Y905-p - gp130 (human) ▲

Modsite: DEGMPKSyLPQtVRQ SwissProt Entrez-Gene Orthologous residues gp130 (human): Y905‑p, gp130 iso2 (human): ‑, gp130 iso3 (human): Y844‑p, gp130 (mouse): Y904‑p, gp130 (rat): Y905‑p Characterization Methods used to characterize site in vivo:  mutation of modification site Relevant cell lines - cell types - tissues:  BaF3 ('B lymphocyte, precursor'), HepG2 (hepatic) Cellular systems studied:  cell lines Species studied:  human, mouse Downstream Regulation Effect of modification (process):  cell cycle regulation, transcription, altered

Y915-p - gp130 (human) ▲

Modsite: QtVRQGGyMPQ____ SwissProt Entrez-Gene Orthologous residues gp130 (human): Y915‑p, gp130 iso2 (human): ‑, gp130 iso3 (human): Y854‑p, gp130 (mouse): Y914‑p, gp130 (rat): Y915‑p Characterization Methods used to characterize site in vivo:  mutation of modification site Relevant cell lines - cell types - tissues:  BaF3 ('B lymphocyte, precursor'), HepG2 (hepatic) Cellular systems studied:  cell lines Species studied:  human, mouse Downstream Regulation Effect of modification (process):  cell cycle regulation, transcription, altered