Curated Information
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Home > Curated Information Page > PubMed Id: 30976076
Rogers C, et al. (2019) Gasdermin pores permeabilize mitochondria to augment caspase-3 activation during apoptosis and inflammasome activation. Nat Commun 10, 1689 30976076
This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2015, 43:D512-20). To learn more about the scope of PhosphoSitePlus®, click here.
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T6-p - DFNA5 (human)
Modsite: __MFAkAtRNFLREV SwissProt Entrez-Gene
Orthologous residues
DFNA5 (human): T6‑p, DFNA5 (mouse): T6‑p, DFNA5 (rat): T6‑p
Methods used to characterize site in vivo immunoprecipitation, mutation of modification site, western blotting
Relevant cell lines - cell types - tissues:  CEM-C7 cell line, HEK293T (epithelial)
Cellular systems studied:  cell lines
Downstream Regulation
Effect of modification (function):  activity, inhibited, intracellular localization, molecular association, regulation
Effect of modification (process):  apoptosis, inhibited, signaling pathway regulation
Modification regulates interactions with: 
Interacting molecule Interacting domains Effect Consequences (function) Consequences (process) Detection assays
DFNA5 (human) Disrupts electrophoretic visualization