Curated Information
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Home > Curated Information Page > PubMed Id: 20395957
Yoon CH, Miah MA, Kim KP, Bae YS (2010) New Cdc2 Tyr 4 phosphorylation by dsRNA-activated protein kinase triggers Cdc2 polyubiquitination and G2 arrest under genotoxic stresses. EMBO Rep 11, 393-9 20395957
This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2015, 43:D512-20). To learn more about the scope of PhosphoSitePlus®, click here.
Click on the protein name to open the protein page, and on the RSD number to open the site page.

Y4-p - CDK1 (human)
Modsite: ____MEDytkIEkIG SwissProt Entrez-Gene
Orthologous residues
CDK1 (human): Y4‑p, CDK1 iso2 (human): Y4‑p, CDK1 (mouse): Y4‑p, CDK1 (rat): Y4‑p, CDK1 (chicken): Y4‑p, CDK1 (fruit fly): F4‑p
Methods used to characterize site in vivo mass spectrometry (in vitro), mutation of modification site, peptide sequencing, western blotting
Relevant cell lines - cell types - tissues:  293 (epithelial)
Cellular systems studied:  cell lines
Species studied:  human
Enzymes shown to modify site in vitro
Type Enzyme
KINASE PKR (human)
Upstream Regulation
Potential in vivo enzymes for site: 
Type Enzyme Evidence Notes
KINASE PKR (human) transfection of inactive enzyme, transfection of wild-type enzyme
Downstream Regulation
Effect of modification (function):  protein degradation, ubiquitination
Effect of modification (process):  cell cycle regulation