Curated Information
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Home > Curated Information Page > PubMed Id: 19776009
Corsi JM, et al. (2009) Autophosphorylation-independent and -dependent functions of focal adhesion kinase during development. J Biol Chem 284, 34769-76 19776009
This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2015, 43:D512-20). To learn more about the scope of PhosphoSitePlus®, click here.
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Y421-p - Cortactin (mouse)
Modsite: RPPssPIyEDAAPFK SwissProt Entrez-Gene
Orthologous residues
Cortactin (human): Y421‑p, Cortactin iso2 (human): Y384‑p, Cortactin iso3 (human): Y384‑p, Cortactin (mouse): Y421‑p, Cortactin (rat): Y383‑p
Characterization
Methods used to characterize site in vivo phospho-antibody, western blotting
Relevant cell lines - cell types - tissues:  MEF (fibroblast) [FAK iso2 (mouse), transgenic]
Cellular systems studied:  primary cells
Species studied:  mouse
Comments:  FAK Y397 (autophosphorylation site) deletion mutant
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
fibronectin increase not changed by FAK Y397 deletion mutant

Y397-p - FAK (mouse)
Modsite: sVsEtDDyAEIIDEE SwissProt Entrez-Gene
Orthologous residues
FAK (human): Y397‑p, FAK iso2 (human): Y216‑p, FAK iso5 (human): Y397‑p, FAK (mouse): Y397‑p, FAK iso2 (mouse): Y428‑p, FAK iso4 (mouse): Y397‑p, FAK iso9 (mouse): , FAK (rat): Y397‑p, FAK (chicken): Y397‑p, FAK iso5 (chicken):
Characterization
Methods used to characterize site in vivo phospho-antibody, western blotting
Relevant cell lines - cell types - tissues:  MEF (fibroblast) [FAK iso2 (mouse), transgenic]
Cellular systems studied:  primary cells
Species studied:  mouse
Comments:  FAK Y397 (autophosphorylation site) deletion mutant
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
fibronectin FAK iso2 (mouse) increase increase abolished in FAK Y397 deletion mutant

Y576-p - FAK (mouse)
Modsite: RyMEDstyyKASKGK SwissProt Entrez-Gene
Orthologous residues
FAK (human): Y576‑p, FAK iso2 (human): Y424‑p, FAK iso5 (human): Y576‑p, FAK (mouse): Y576‑p, FAK iso2 (mouse): Y607‑p, FAK iso4 (mouse): Y576‑p, FAK iso9 (mouse): , FAK (rat): Y576‑p, FAK (chicken): Y576‑p, FAK iso5 (chicken):
Characterization
Methods used to characterize site in vivo phospho-antibody, western blotting
Relevant cell lines - cell types - tissues:  MEF (fibroblast) [FAK iso2 (mouse), transgenic]
Cellular systems studied:  primary cells
Species studied:  mouse
Comments:  FAK Y397 (autophosphorylation site) deletion mutant
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
fibronectin FAK iso2 (mouse) increase increase abolished in FAK Y397 deletion mutant

Y577-p - FAK (mouse)
Modsite: yMEDstyyKASKGKL SwissProt Entrez-Gene
Orthologous residues
FAK (human): Y577‑p, FAK iso2 (human): Y425‑p, FAK iso5 (human): Y577‑p, FAK (mouse): Y577‑p, FAK iso2 (mouse): Y608‑p, FAK iso4 (mouse): Y577‑p, FAK iso9 (mouse): , FAK (rat): Y577‑p, FAK (chicken): Y577‑p, FAK iso5 (chicken):
Characterization
Methods used to characterize site in vivo phospho-antibody, western blotting
Relevant cell lines - cell types - tissues:  MEF (fibroblast) [FAK iso2 (mouse), transgenic]
Cellular systems studied:  primary cells
Species studied:  mouse
Comments:  FAK Y397 (autophosphorylation site) deletion mutant
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
fibronectin FAK iso2 (mouse) increase increase abolished in FAK Y397 deletion mutant

Y925-p - FAK (mouse)
Modsite: DRSNDKVyENVTGLV SwissProt Entrez-Gene
Orthologous residues
FAK (human): Y925‑p, FAK iso2 (human): Y752‑p, FAK iso5 (human): Y938‑p, FAK (mouse): Y925‑p, FAK iso2 (mouse): Y956‑p, FAK iso4 (mouse): Y928‑p, FAK iso9 (mouse): Y233‑p, FAK (rat): Y928‑p, FAK (chicken): Y926‑p, FAK iso5 (chicken): Y232‑p
Characterization
Methods used to characterize site in vivo phospho-antibody, western blotting
Relevant cell lines - cell types - tissues:  MEF (fibroblast) [FAK iso2 (mouse), transgenic]
Cellular systems studied:  primary cells
Species studied:  mouse
Comments:  FAK Y397 (autophosphorylation site) deletion mutant
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
fibronectin FAK iso2 (mouse) increase increase abolished in FAK Y397 deletion mutant

Y414-p - P130Cas (mouse)
Modsite: sVVDDGVyAVPPPAE SwissProt Entrez-Gene
Orthologous residues
P130Cas (human): Y410‑p, P130Cas iso2 (human): Y428‑p, P130Cas iso6 (human): Y456‑p, P130Cas iso7 (human): Y428‑p, P130Cas iso8 (human): Y410‑p, P130Cas (mouse): Y414‑p, P130Cas (rat): Y508‑p, P130Cas iso2 (rat): Y414‑p
Characterization
Methods used to characterize site in vivo phospho-antibody, western blotting
Relevant cell lines - cell types - tissues:  MEF (fibroblast) [FAK iso2 (mouse), transgenic]
Cellular systems studied:  primary cells
Species studied:  mouse
Comments:  FAK Y397 (autophosphorylation site) deletion mutant
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
fibronectin FAK iso2 (mouse) increase increase abolished in FAK Y397 deletion mutant

Y118-p - PXN (mouse)
Modsite: AGEEEHVysFPNKQk SwissProt Entrez-Gene
Orthologous residues
PXN (human): Y118‑p, PXN iso2 (human): Y118‑p, PXN iso3 (human): Y118‑p, PXN (mouse): Y118‑p, PXN iso2 (mouse): Y118‑p, PXN (rat): Y118‑p, PXN (chicken): Y118‑p, PXN (cow): Y112‑p
Characterization
Methods used to characterize site in vivo phospho-antibody, western blotting
Relevant cell lines - cell types - tissues:  MEF (fibroblast) [FAK iso2 (mouse), transgenic]
Cellular systems studied:  primary cells
Species studied:  mouse
Comments:  FAK Y397 (autophosphorylation site) deletion mutant
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
fibronectin FAK iso2 (mouse) increase increase abolished in FAK Y397 deletion mutant