Curated Information
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Home > Curated Information Page > PubMed Id: 20222050
Li JM, Li YC, Kong LD, Hu QH (2010) Curcumin inhibits hepatic protein-tyrosine phosphatase 1B and prevents hypertriglyceridemia and hepatic steatosis in fructose-fed rats. Hepatology 51, 1555-66 20222050
This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2015, 43:D512-20). To learn more about the scope of PhosphoSitePlus®, click here.
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Y985-p - LEPR (rat)
Modsite: QSQPSVKyATLVSNV SwissProt
Orthologous residues
LEPR (human): Y986‑p, LEPR iso2 (human): , LEPR (mouse): Y985‑p, LEPR iso6 (mouse): Y985‑p, LEPR (rat): Y985‑p
Characterization
Methods used to characterize site in vivo phospho-antibody, western blotting
Relevant cell lines - cell types - tissues:  liver
Cellular systems studied:  tissue
Species studied:  rat
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
fructose no change compared to control
curcumin no change compared to control
pioglitazone no change compared to control

Y1138-p - LEPR (rat)
Modsite: SGKNFVPyMPQFQSC SwissProt
Orthologous residues
LEPR (human): Y1141‑p, LEPR iso2 (human): , LEPR (mouse): Y1138‑p, LEPR iso6 (mouse): Y1138‑p, LEPR (rat): Y1138‑p
Characterization
Methods used to characterize site in vivo phospho-antibody, western blotting
Relevant cell lines - cell types - tissues:  liver
Cellular systems studied:  tissue
Species studied:  rat
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
fructose increase
curcumin fructose inhibit treatment-induced increase
pioglitazone fructose inhibit treatment-induced increase

Y705-p - STAT3 (rat)
Modsite: DPGSAAPyLKTKFIC SwissProt Entrez-Gene
Orthologous residues
STAT3 (human): Y705‑p, STAT3 iso2 (human): Y704‑p, STAT3 iso3 (human): Y705‑p, STAT3 (mouse): Y705‑p, STAT3 iso2 (mouse): Y705‑p, STAT3 iso3 (mouse): Y704‑p, STAT3 (rat): Y705‑p, STAT3 (cow): Y705‑p
Characterization
Methods used to characterize site in vivo phospho-antibody, western blotting
Relevant cell lines - cell types - tissues:  liver
Cellular systems studied:  tissue
Species studied:  rat
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
fructose increase
curcumin fructose inhibit treatment-induced increase
pioglitazone fructose no effect upon treatment-induced increase