Curated Information
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Home > Curated Information Page > PubMed Id: 20170763
Fujii K, Nakamura S, Takahashi K, Inagaki F (2010) Systematic characterization by mass spectrometric analysis of phosphorylation sites in IRF-3 regulatory domain activated by IKK-i. J Proteomics 73, 1196-203 20170763
This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2015, 43:D512-20). To learn more about the scope of PhosphoSitePlus®, click here.
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S386-p - IRF3 (human)
Modsite: ARVGGAssLENtVDL SwissProt Entrez-Gene
Orthologous residues
IRF3 (human): S386‑p, IRF3 (mouse): S379‑p, IRF3 (rat): S381‑p
Characterization
Methods used to characterize site in vivo mass spectrometry
Relevant cell lines - cell types - tissues:  E.coli (bacterial) [IKKE (human), transfection]
Cellular systems studied:  cell lines
Species studied:  bacteria
Upstream Regulation
Potential in vivo enzymes for site: 
Type Enzyme Evidence Notes
KINASE IKKE (human) transfection of wild-type enzyme

S396-p - IRF3 (human)
Modsite: NtVDLHIsNsHPLsL SwissProt Entrez-Gene
Orthologous residues
IRF3 (human): S396‑p, IRF3 (mouse): S388‑p, IRF3 (rat): S390‑p
Characterization
Methods used to characterize site in vivo mass spectrometry
Relevant cell lines - cell types - tissues:  E.coli (bacterial) [IKKE (human), transfection]
Cellular systems studied:  cell lines
Species studied:  bacteria
Upstream Regulation
Potential in vivo enzymes for site: 
Type Enzyme Evidence Notes
KINASE IKKE (human) transfection of wild-type enzyme

S402-p - IRF3 (human)
Modsite: IsNsHPLsLtsDQYK SwissProt Entrez-Gene
Orthologous residues
IRF3 (human): S402‑p, IRF3 (mouse): S394‑p, IRF3 (rat): S396‑p
Characterization
Methods used to characterize site in vivo mass spectrometry
Relevant cell lines - cell types - tissues:  E.coli (bacterial) [IKKE (human), transfection]
Cellular systems studied:  cell lines
Species studied:  bacteria
Upstream Regulation
Potential in vivo enzymes for site: 
Type Enzyme Evidence Notes
KINASE IKKE (human) transfection of wild-type enzyme