O'Connor DS, et al. (2000) Regulation of apoptosis at cell division by p34cdc2 phosphorylation of survivin. Proc Natl Acad Sci U S A 97, 13103-7 11069302

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T34-p - Survivin (human) ▲

Modsite: FLEGCACtPERMAEA SwissProt Entrez-Gene Orthologous residues Survivin (human): T34‑p, Survivin iso2 (human): T34‑p, Survivin (mouse): T34‑p, Survivin iso2 (mouse): T34‑p, Survivin (rat): T34‑p Characterization Methods used to characterize site in vivo:  [32P] bio-synthetic labeling, mutation of modification site, phospho-antibody Relevant cell lines - cell types - tissues:  HeLa (cervical), YUSAC2 (melanocyte) Cellular systems studied:  cell lines Species studied:  human Enzymes shown to modify site in vitro:  Type Enzyme KINASE CDK1 (human) Upstream Regulation Potential in vivo enzymes for site:  Type Enzyme Evidence Notes KINASE CDK1 (human) transfection of inactive enzyme Downstream Regulation Effect of modification (function):  molecular association, regulation Effect of modification (process):  apoptosis, inhibited Modification regulates interactions with:  Interacting molecule Interacting domains Effect Consequences (function) Consequences (process) Detection assays CASP9 (human) Induces apoptosis, altered electrophoretic visualization, co-immunoprecipitation