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Home > Curated Information Page > PubMed Id: 28634194
Kesavardhana S, et al. (2017) ZBP1/DAI ubiquitination and sensing of influenza vRNPs activate programmed cell death. J Exp Med 214, 2217-2229 28634194
This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2015, 43:D512-20). To learn more about the scope of PhosphoSitePlus®, click here.
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K17-ub - ZBP1 (mouse)
Modsite: TGDNLEQkILQVLSD SwissProt Entrez-Gene
Orthologous residues
ZBP1 (human): R17‑ub, ZBP1 (mouse): K17‑ub, ZBP1 iso2 (mouse): K17‑ub, ZBP1 (rat): K17‑ub
Characterization
Methods used to characterize site in vivo immunoprecipitation, mass spectrometry, western blotting
Relevant cell lines - cell types - tissues:  fibroblast, macrophage-bone marrow
Cellular systems studied:  primary cultured cells
Species studied:  mouse
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
virus infection increase
IFN-beta increase
Downstream Regulation
Effect of modification (process):  apoptosis, induced
Comments:  induces apoptosis due to influenza A virus infection

K43-ub - ZBP1 (mouse)
Modsite: KKCQVPKkTLNQVLY SwissProt Entrez-Gene
Orthologous residues
ZBP1 (human): R43‑ub, ZBP1 (mouse): K43‑ub, ZBP1 iso2 (mouse): K43‑ub, ZBP1 (rat): K43‑ub
Characterization
Methods used to characterize site in vivo immunoprecipitation, mass spectrometry, western blotting
Relevant cell lines - cell types - tissues:  fibroblast, macrophage-bone marrow
Cellular systems studied:  primary cultured cells
Species studied:  mouse
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
virus infection increase
IFN-beta increase
Downstream Regulation
Effect of modification (process):  apoptosis, induced
Comments:  induces apoptosis due to influenza A virus infection