Henkels KM, Peng HJ, Frondorf K, Gomez-Cambronero J (2010) A comprehensive model that explains the regulation of phospholipase D2 activity by phosphorylation-dephosphorylation. Mol Cell Biol 30, 2251-63 20176813

This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2015, 43:D512-20). To learn more about the scope of PhosphoSitePlus®, click here.

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Y296-p - PLD2 (human) ▲

Modsite: LILkCSSyRQARWWA SwissProt Entrez-Gene Orthologous residues PLD2 (human): Y296‑p, PLD2 (mouse): Y296‑p, PLD2 (rat): Y296‑p Characterization Methods used to characterize site in vivo:  mass spectrometry (in vitro), mutation of modification site, western blotting Disease tissue studied:  breast cancer Relevant cell lines - cell types - tissues:  COS (fibroblast), MCF-7 (breast cell), MTLn3 (breast cell) Cellular systems studied:  cell lines Species studied:  green monkey, human, rat Enzymes shown to modify site in vitro:  Type Enzyme KINASE EGFR (human) Downstream Regulation Effect of modification (function):  enzymatic activity, induced, enzymatic activity, inhibited Effect of modification (process):  carcinogenesis, inhibited Comments:  in COS-7 cells, in MTLn3 and MCF-7 cells

Y415-p - PLD2 (human) ▲

Modsite: ALGINSGysKRALML SwissProt Entrez-Gene Orthologous residues PLD2 (human): Y415‑p, PLD2 (mouse): Y415‑p, PLD2 (rat): Y415‑p Characterization Methods used to characterize site in vivo:  mass spectrometry (in vitro), mutation of modification site, western blotting Disease tissue studied:  breast cancer Relevant cell lines - cell types - tissues:  COS (fibroblast), MCF-7 (breast cell), MTLn3 (breast cell) Cellular systems studied:  cell lines Species studied:  green monkey, human, rat Enzymes shown to modify site in vitro:  Type Enzyme KINASE JAK3 (human) Downstream Regulation Effect of modification (function):  enzymatic activity, induced

Y511-p - PLD2 (human) ▲

Modsite: FFWLGKDySNLITKD SwissProt Entrez-Gene Orthologous residues PLD2 (human): Y511‑p, PLD2 (mouse): Y511‑p, PLD2 (rat): Y511‑p Characterization Methods used to characterize site in vivo:  mass spectrometry (in vitro), mutation of modification site, western blotting Disease tissue studied:  breast cancer Relevant cell lines - cell types - tissues:  COS (fibroblast), MCF-7 (breast cell), MTLn3 (breast cell) Cellular systems studied:  cell lines Species studied:  green monkey, human, rat Enzymes shown to modify site in vitro:  Type Enzyme KINASE Src (human) Downstream Regulation Effect of modification (function):  enzymatic activity, induced