Curated Information
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Home > Curated Information Page > PubMed Id: 12112843
Maguire PB, et al. (2002) Identification of the phosphotyrosine proteome from thrombin activated platelets. Proteomics 2, 642-8 12112843
This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2015, 43:D512-20). To learn more about the scope of PhosphoSitePlus®, click here.
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Y77-p - ADK (human)
Modsite: VkKFKVEyHAGGSTQ SwissProt Entrez-Gene
Orthologous residues
ADK (human): Y77‑p, ADK (mouse): Y76‑p, ADK (rat): Y76‑p
Characterization
Methods used to characterize site in vivo 2D analysis, mass spectrometry
Relevant cell lines - cell types - tissues:  platelet-blood
Cellular systems studied:  primary cells
Species studied:  human
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
thrombin increase

Y380-p - ALK4 (human)
Modsite: QRVGTKRyMAPEVLD SwissProt Entrez-Gene
Orthologous residues
ALK4 (human): Y380‑p, ALK4 iso3 (human): Y380‑p, ALK4 iso4 (human): Y421‑p, ALK4 (mouse): Y380‑p, ALK4 (rat): Y380‑p
Characterization
Methods used to characterize site in vivo 2D analysis, mass spectrometry
Relevant cell lines - cell types - tissues:  platelet-blood
Cellular systems studied:  primary cells
Species studied:  human
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
thrombin increase

Y182-p - FGB (human)
Modsite: ELEKHQLyIDETVNS SwissProt Entrez-Gene
Orthologous residues
FGB (human): Y182‑p, FGB (mouse): Y172‑p, FGB (rat): Y170‑p
Characterization
Methods used to characterize site in vivo 2D analysis, mass spectrometry
Relevant cell lines - cell types - tissues:  platelet-blood
Cellular systems studied:  primary cells
Species studied:  human
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
thrombin increase

Y205-p - NAGK (human)
Modsite: LGILTHLyRDFDKCR SwissProt Entrez-Gene
Orthologous residues
NAGK (human): Y205‑p, NAGK iso2 (human): Y251‑p, NAGK (mouse): Y205‑p, NAGK (rat): Y205‑p
Characterization
Methods used to characterize site in vivo 2D analysis, mass spectrometry
Relevant cell lines - cell types - tissues:  platelet-blood
Cellular systems studied:  primary cells
Species studied:  human
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
thrombin increase

Y64-p - P2X6 (human)
Modsite: ALLAKKGyQERDLEP SwissProt Entrez-Gene
Orthologous residues
P2X6 (human): Y64‑p, P2X6 (mouse): Y66‑p
Characterization
Methods used to characterize site in vivo 2D analysis, mass spectrometry
Relevant cell lines - cell types - tissues:  platelet-blood
Cellular systems studied:  primary cells
Species studied:  human
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
thrombin increase

Y442-p - WNK2 (human)
Modsite: CKNKEERyEIKDLLS SwissProt Entrez-Gene
Orthologous residues
WNK2 (human): Y442‑p, WNK2 (mouse): Y442‑p, WNK2 (rat): Y442‑p
Characterization
Methods used to characterize site in vivo 2D analysis, mass spectrometry
Relevant cell lines - cell types - tissues:  platelet-blood
Cellular systems studied:  primary cells
Species studied:  human
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
thrombin increase