Curated Information
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Home > Curated Information Page > PubMed Id: 9230306
Rochette-Egly C, et al. (1997) Stimulation of RAR alpha activation function AF-1 through binding to the general transcription factor TFIIH and phosphorylation by CDK7. Cell 90, 97-107 9230306
This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2015, 43:D512-20). To learn more about the scope of PhosphoSitePlus®, click here.
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S77-p - RARA (mouse)
Modsite: EIVPSPPsPPPLPRI SwissProt Entrez-Gene
Orthologous residues
RARA (human): S77‑p, RARA iso2 (human): S72‑p, RARA (mouse): S77‑p, RARA (rat): S74‑p
Characterization
Methods used to characterize site in vivo 2D analysis, immunoprecipitation, mutation of modification site, phosphopeptide mapping, western blotting
Relevant cell lines - cell types - tissues:  COS (fibroblast)
Cellular systems studied:  cell lines
Species studied:  green monkey
Enzymes shown to modify site in vitro
Type Enzyme
KINASE CDK7 (human)
KINASE CDK1 (human)
Upstream Regulation
Potential in vivo enzymes for site: 
Type Enzyme Evidence Notes
KINASE CDK7 (human) 2D analysis, transfection of wild-type enzyme, co-immunoprecipitation
Downstream Regulation
Effect of modification (function):  activity, induced
Effect of modification (process):  transcription, altered

S445-p - RARA (mouse)
Modsite: APPPGSCsPSLSPSS SwissProt Entrez-Gene
Orthologous residues
RARA (human): S445‑p, RARA iso2 (human): S440‑p, RARA (mouse): S445‑p, RARA (rat): S442‑p
Characterization
Methods used to characterize site in vivo 2D analysis, mutation of modification site, phosphopeptide mapping
Relevant cell lines - cell types - tissues:  COS (fibroblast)
Cellular systems studied:  cell lines
Species studied:  green monkey

S449-p - RARA (mouse)
Modsite: GSCSPSLsPSSHRSS SwissProt Entrez-Gene
Orthologous residues
RARA (human): S449‑p, RARA iso2 (human): S444‑p, RARA (mouse): S449‑p, RARA (rat): S446‑p
Characterization
Methods used to characterize site in vivo 2D analysis, mutation of modification site, phosphopeptide mapping
Relevant cell lines - cell types - tissues:  COS (fibroblast)
Cellular systems studied:  cell lines
Species studied:  green monkey

S456-p - RARA (mouse)
Modsite: SPSSHRSsPATQSP_ SwissProt Entrez-Gene
Orthologous residues
RARA (human): S456‑p, RARA iso2 (human): S451‑p, RARA (mouse): S456‑p, RARA (rat): S453‑p
Characterization
Methods used to characterize site in vivo 2D analysis, mutation of modification site, phosphopeptide mapping
Relevant cell lines - cell types - tissues:  COS (fibroblast)
Cellular systems studied:  cell lines
Species studied:  green monkey

S461-p - RARA (mouse)
Modsite: RSSPATQsP______ SwissProt Entrez-Gene
Orthologous residues
RARA (human): S461‑p, RARA iso2 (human): S456‑p, RARA (mouse): S461‑p, RARA (rat): S458‑p
Characterization
Methods used to characterize site in vivo 2D analysis, mutation of modification site, phosphopeptide mapping
Relevant cell lines - cell types - tissues:  COS (fibroblast)
Cellular systems studied:  cell lines
Species studied:  green monkey
Enzymes shown to modify site in vitro
Type Enzyme
KINASE CDK1 (human)
KINASE CDK7 (human)