Sfichi-Duke L, et al. (2010) Cardiomyopathy-causing deletion K210 in cardiac troponin T alters phosphorylation propensity of sarcomeric proteins. J Mol Cell Cardiol 48, 934-42 20079745

This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2015, 43:D512-20). To learn more about the scope of PhosphoSitePlus®, click here.

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S23-p - TNNI3 (mouse) ▲

Modsite: PAPVRRRssANyRAY SwissProt Entrez-Gene Orthologous residues TNNI3 (human): S23‑p, TNNI3 (mouse): S23‑p, TNNI3 (rat): S23‑p, TNNI3 (rabbit): S22‑p, TNNI3 (dog): S23‑p, TNNI3 (cow): S24‑p Characterization Methods used to characterize site in vivo:  phospho-antibody, western blotting Relevant cell lines - cell types - tissues:  myocardium Cellular systems studied:  tissue Species studied:  mouse Comments:  TNNT2 K120 knock-in mice Upstream Regulation Treatments, proteins and their effect on site modification:  Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes TNNT2 (mouse) decrease TNNT2 K210 knock-in mice

S24-p - TNNI3 (mouse) ▲

Modsite: APVRRRssANyRAYA SwissProt Entrez-Gene Orthologous residues TNNI3 (human): S24‑p, TNNI3 (mouse): S24‑p, TNNI3 (rat): S24‑p, TNNI3 (rabbit): S23‑p, TNNI3 (dog): S24‑p, TNNI3 (cow): S25‑p Characterization Methods used to characterize site in vivo:  phospho-antibody, western blotting Relevant cell lines - cell types - tissues:  myocardium Cellular systems studied:  tissue Species studied:  mouse Comments:  TNNT2 K120 knock-in mice Upstream Regulation Treatments, proteins and their effect on site modification:  Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes TNNT2 (mouse) decrease TNNT2 K210 knock-in mice

T216-p - TNNT2 (mouse) ▲

Modsite: RKsGKRQtEREKKKK SwissProt Entrez-Gene Orthologous residues TNNT2 (human): T213‑p, TNNT2 (mouse): T216‑p, TNNT2 iso2 (mouse): T203‑p, TNNT2 (rat): T214‑p, TNNT2 iso2 (rat): T204‑p, TNNT2 (rabbit): T216‑p, TNNT2 (cow): T200‑p Characterization Methods used to characterize site in vivo:  phospho-antibody, western blotting Relevant cell lines - cell types - tissues:  myocardium Cellular systems studied:  tissue Species studied:  mouse Comments:  TNNT2 K120 knock-in mice Enzymes shown to modify site in vitro:  Type Enzyme KINASE PKCA (human) Upstream Regulation Treatments, proteins and their effect on site modification:  Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes TNNT2 (mouse) increase TNNT2 K210 knock-in mice

S288-p - TNNT2 (mouse) ▲

Modsite: INDNQkVsKTRGKAK SwissProt Entrez-Gene Orthologous residues TNNT2 (human): S285‑p, TNNT2 (mouse): S288‑p, TNNT2 iso2 (mouse): S275‑p, TNNT2 (rat): S286‑p, TNNT2 iso2 (rat): S276‑p, TNNT2 (rabbit): S288‑p, TNNT2 (cow): S272‑p Characterization Methods used to characterize site in vivo:  phospho-antibody, western blotting Relevant cell lines - cell types - tissues:  myocardium Cellular systems studied:  tissue Species studied:  mouse Comments:  TNNT2 K120 knock-in mice Upstream Regulation Treatments, proteins and their effect on site modification:  Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes TNNT2 (mouse) decrease TNNT2 K210 knock-in mice

T297-p - TNNT2 (mouse) ▲

Modsite: TRGKAKVtGRWK___ SwissProt Entrez-Gene Orthologous residues TNNT2 (human): T294‑p, TNNT2 (mouse): T297‑p, TNNT2 iso2 (mouse): T284‑p, TNNT2 (rat): T295‑p, TNNT2 iso2 (rat): T285‑p, TNNT2 (rabbit): T297‑p, TNNT2 (cow): T281‑p Characterization Methods used to characterize site in vivo:  phospho-antibody, western blotting Relevant cell lines - cell types - tissues:  myocardium Cellular systems studied:  tissue Species studied:  mouse Comments:  TNNT2 K120 knock-in mice Enzymes shown to modify site in vitro:  Type Enzyme KINASE PKCA (human) Upstream Regulation Treatments, proteins and their effect on site modification:  Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes TNNT2 (mouse) decrease TNNT2 K210 knock-in mice