Pal S, et al. (2004) Human SWI/SNF-associated PRMT5 methylates histone H3 arginine 8 and negatively regulates expression of ST7 and NM23 tumor suppressor genes. Mol Cell Biol 24, 9630-45 15485929

This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2015, 43:D512-20). To learn more about the scope of PhosphoSitePlus®, click here.

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R8-me - H3 (human) ▲

Modsite: ArtkQtArkstGGkA SwissProt Entrez-Gene Orthologous residues H3 (human): R8‑me, H3 (mouse): R8‑me, H3 iso2 (mouse): R8‑me, H3 iso3 (mouse): R8‑me, H3 (rat): R8‑me, H3 iso3 (rat): R8‑me, H3 (pig): R8‑me, H3 (chicken): R8‑me, H3 (cow): R8‑me Characterization Methods used to characterize site in vivo:  immunoprecipitation, modification-specific antibody Disease tissue studied:  cervical cancer, cervical adenocarcinoma Relevant cell lines - cell types - tissues:  HeLa S3 (cervical) Cellular systems studied:  cell lines Species studied:  human Enzymes shown to modify site in vitro:  Type Enzyme METHYLTRANSFERASE PRMT5 (human) Downstream Regulation Effect of modification (function):  acetylation

R8-m2 - H3 (human) ▲

Modsite: ArtkQtArkstGGkA SwissProt Entrez-Gene Orthologous residues H3 (human): R8‑m2, H3 (mouse): R8‑m2, H3 iso2 (mouse): R8‑m2, H3 iso3 (mouse): R8‑m2, H3 (rat): R8‑m2, H3 iso3 (rat): R8‑m2, H3 (pig): R8‑m2, H3 (chicken): R8‑m2, H3 (cow): R8‑m2 Characterization Methods used to characterize site in vivo:  immunoprecipitation, modification-specific antibody Disease tissue studied:  cervical cancer, cervical adenocarcinoma Relevant cell lines - cell types - tissues:  HeLa S3 (cervical) Cellular systems studied:  cell lines Species studied:  human

K9-ac - H3 (human) ▲

Modsite: rtkQtArkstGGkAP SwissProt Entrez-Gene Orthologous residues H3 (human): K9‑ac, H3 (mouse): K9‑ac, H3 iso2 (mouse): K9‑ac, H3 iso3 (mouse): K9‑ac, H3 (rat): K9‑ac, H3 iso3 (rat): K9‑ac, H3 (pig): K9‑ac, H3 (chicken): K9‑ac, H3 (cow): K9‑ac Characterization Methods used to characterize site in vivo:  immunoprecipitation, modification-specific antibody Disease tissue studied:  cervical cancer, cervical adenocarcinoma Relevant cell lines - cell types - tissues:  HeLa S3 (cervical) Cellular systems studied:  cell lines Species studied:  human Upstream Regulation Potential in vivo enzymes for site:  Type Enzyme Evidence Notes METHYLTRANSFERASE PRMT5 (human) transfection of wild-type enzyme, siRNA inhibition of enzyme

R3-me - H4 (human) ▲

Modsite: _____sGrGkGGkGL SwissProt Entrez-Gene Orthologous residues H4 (human): R3‑me, H4 (mouse): R3‑me, H4 (rat): R3‑me, H4 (pig): R3‑me, H4 (cow): R3‑me Characterization Methods used to characterize site in vivo:  immunoprecipitation, modification-specific antibody Disease tissue studied:  cervical cancer, cervical adenocarcinoma Relevant cell lines - cell types - tissues:  HeLa S3 (cervical) Cellular systems studied:  cell lines Species studied:  human Enzymes shown to modify site in vitro:  Type Enzyme METHYLTRANSFERASE PRMT5 (human) Upstream Regulation Potential in vivo enzymes for site:  Type Enzyme Evidence Notes METHYLTRANSFERASE PRMT5 (human) transfection of wild-type enzyme, siRNA inhibition of enzyme